Targeting M. catarrhalis for Prevention and Treatment of Otitis Media

针对卡他莫拉菌预防和治疗中耳炎

基本信息

批准号：
9915881
负责人：
Anthony A Campagnari
金额：
$ 39.8万
依托单位：
STATE UNIVERSITY OF NEW YORK AT BUFFALO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9915881
关键词：
Active Immunization Acute Adherence Adult Antibiotic Resistance Antibiotics Area Bacteria Child Chinchilla (genus)Chronic Chronic Disease Complex Development Disease Environment Goals Health Care Costs Healthcare Systems Host Defense Human Immune system Immunization In Vitro Incidence Infant Infection International Lead Learning Learning Skill Life Lung diseases Metabolic Clearance Rate Microbial Biofilms Modeling Modification Moraxella catarrhalis Morbidity - disease rate Mucous Membrane Nontypable Haemophilus influenza Office Visits Operative Surgical Procedures Otitis Media PUVA Photochemotherapy Physiological Prevention Published Comment Recurrence Recurrent disease Reporting Research Research Project Grants Resistance development Risk Role School-Age Population Sinusitis Source Speech Development Streptococcus pneumoniae Stress Structure Surface Testing Time Treatment Protocols Tympanostomy Tube Insertions Vaccine Antigen antimicrobial bactericide design effective therapy experience hearing impairment human pathogen in vivo interest middle ear middle ear disorder novel novel therapeutic intervention novel therapeutics ototoxicity pathogen pediatrician polymicrobial biofilm prevent public health relevance response symposium therapy design

项目摘要

DESCRIPTION (provided by applicant): Moraxella catarrhalis, a Gram-negative bacterial mucosal pathogen, is a significant cause of middle ear infections (otitis media (OM)) and sinusitis in infants and children and an important source of exacerbations in adults with lung disease. Approximately 80% of all children under 3 will experience at least one episode of OM and many experience recurrent disease, which may result in hearing impairment and developmental/learning problems. OM is a significant source of direct and indirect health care costs and M. catarrhalis is responsible for 3 to 4 million pediatrician office visits annually. Chronic or recurrent OM is now considered a biofilm disease and there have been numerous reports demonstrating that M. catarrhalis forms biofilms in vivo. Biofilms on host surfaces promote adherence and persistence on mucosal tissues, provide protection from host defenses and antibiotics, and represent a primary source of chronic disease. Importantly, multiple studies have suggested that nasopharyngeal colonization with M. catarrhalis promotes subsequent persistent colonization with the two other major otopathogens Streptococcus pneumoniae and/or nontypeable Haemophilus influenzae (NTHI), resulting in a significantly increased risk of OM. The first goal of this proposed research project is to provide a thorough understanding of the contribution of M. catarrhalis to the stable and persistent colonization of the other otopathogens, which then potentiates the development of OM. Moreover, novel therapeutic approaches designed to eradicate planktonic and biofilm-associated bacteria from the middle ear would not only significantly decrease the constant use of antibiotics in young children, it would also decrease the associated morbidity and the need to perform surgeries for insertion of tympanostomy tubes. Thus, the second goal of this research plan is to adapt photodynamic therapy (PDT) into an efficacious, noninvasive treatment for both acute and chronic OM resulting from M. catarrhalis monospecies and polymicrobial biofilms.

描述（由适用提供）：一种革兰氏阴性细菌粘膜病原体的摩拉氏菌Catarrhalis是中耳感染（耳炎培养基（OM））和儿童鼻窦炎的重要原因，是成人肺病患者的重要来源。在3岁以下的所有儿童中，大约有80％的人将至少经历一次OM发作和许多经历复发性疾病，这可能导致听力障碍和发展/学习问题。 OM是直接和间接医疗保健费用的重要来源，Cartarrhalis M. Cartarrhalis每年造成3至400万个儿科办公室访问。慢性或经常性OM现在被认为是一种生物膜疾病，有许多报道表明，卡塔哈利菌在体内形成生物膜。宿主表面上的生物膜促进了粘膜组织的粘附和持久性，可保护宿主防御和抗生素，并代表了慢性疾病的主要来源。重要的是，多项研究表明，用卡塔哈里斯氏菌的鼻咽定植可促进随后的持续定殖，并与其他两个主要的耳状疾病肺炎链球菌和/或不可能的血友影响（NTHI）促进了持续定殖，从而大大增加了OM的风险。该拟议的研究项目的第一个目标是对卡塔哈里斯菌对其他局部病原体的稳定和持续定殖的贡献进行透彻的理解，这然后潜在地提高了OM的发展。此外，新型的治疗方法旨在用于放射性浮游症状和与生物膜相关的细菌与中耳的细菌不仅显着减少幼儿抗生素的不断使用，还将降低相关的发病率，并且需要进行插入鼓膜造口管的插入。这是该研究计划的第二个目标是将光动力疗法（PDT）改编成对Cartarrhalis M. cartarrhalis单种和多种生物膜产生的急性和慢性OM的有效，无创治疗。