Uncovering the rules of gut microbiome strain transmission
揭示肠道微生物菌株传播的规则
基本信息
- 批准号:9917242
- 负责人:
- 金额:$ 59.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-20 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAddressAdultAlgorithmsAwarenessBasic ScienceBiologicalBirthBody SurfaceChildClinicalClostridium difficileCollaborationsCommunicable DiseasesComplexComputational algorithmDataDevelopmentDiseaseDonor personEngraftmentEnvironmentFamiliarityFamilyFamily memberFecesFosteringFrequenciesGenesHabitsHealthHumanHuman MicrobiomeImmuneIndividualInfectionIntestinesKnowledgeLifeMetagenomicsMicrobeMonitorParentsPathogenesisPlayRecurrenceResearch PersonnelResourcesRoleRouteSamplingScientistSiblingsSkinSocietiesSpousesStructureTaxonTaxonomyTestingTherapeuticTimeTransplant RecipientsUlcerative ColitisVariantWorkbasebiobankcolonization resistancecomputer frameworkdensitydesigndisorder controldisorder preventiondisorder riskfamily structurefecal microbiomefecal transplantationgut microbesgut microbiomegut microbiotahost microbiomehost microbiotahuman diseaseimprovedmembermetagenomemicrobialmicrobial diseasemicrobiomemicrobiome compositionmicrobiome researchmicrobiotapathogenpathogenic microbetooltranslational studytransmission processwhole genome
项目摘要
PROJECT SUMMARY
As biological scientists and even as members of an educated society, we all have some familiarity with the
fundamental concept that some aspects of our health are influenced by the set of genes we obtained from our
parents. We are also increasingly aware that our body surfaces, from our skin to our intestine, harbor microbial
strains that also influence our health. Given recent discoveries that many of these microbes are stably
colonized for decades and are acquired in early life, it is perhaps unsurprising that some proportion of the
microbes inside you right now were likely acquired from your parents and/or siblings when you were a child
and maintained in your intestine to this day, potentially influencing your health for these past many years. In
addition, we have yet to find clear evidence of a commensal gut microbial strain shared between two unrelated
individuals outside of extreme circumstances of microbial transfer such as fecal microbiota transplantation.
Given the extreme uniqueness of microbial strains at the whole genome level and the rarity of each strain
variant, fecal microbiota transplantation and familial-shared microbes represent the most efficient route to
accurately track and infer basic principles of microbial transmission and sharing. We feel this study will address
an important, unaddressed gap in our basic science knowledge of the gut microbiota. Just as tracking of
classical acute pathogenic microbes plays a key role in disease prevention and treatment, uncovering the
basic principles of microbial sharing and transmission for non-acute pathogen microbes could enable new tools
to quantify disease risk, to understand the importance of the familial microbial strain sharing in disease risk, to
manipulate the gut microbiota to improve health, and ultimately perhaps to enable the prevention of disease
through controlled monitoring or therapeutic addition of microbes that limit disease risk.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeremiah James Faith其他文献
Jeremiah James Faith的其他文献
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{{ truncateString('Jeremiah James Faith', 18)}}的其他基金
Uncovering the rules of gut microbiome strain transmission
揭示肠道微生物菌株传播的规则
- 批准号:
10542736 - 财政年份:2020
- 资助金额:
$ 59.29万 - 项目类别:
Uncovering the rules of gut microbiome strain transmission
揭示肠道微生物菌株传播的规则
- 批准号:
10321886 - 财政年份:2020
- 资助金额:
$ 59.29万 - 项目类别:
Determination of mucosal immune responses to, and infection of the gastrointestinal tract by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
测定严重急性呼吸综合征冠状病毒 (SARS-CoV-2) 的粘膜免疫反应和胃肠道感染
- 批准号:
10179032 - 财政年份:2020
- 资助金额:
$ 59.29万 - 项目类别:
The Influence Of Gut Microbiota Stability In Inflammatory Bowel Disease
肠道菌群稳定性对炎症性肠病的影响
- 批准号:
10311993 - 财政年份:2019
- 资助金额:
$ 59.29万 - 项目类别:
The Influence Of Gut Microbiota Stability In Inflammatory Bowel Disease
肠道微生物群稳定性对炎症性肠病的影响
- 批准号:
9764766 - 财政年份:2019
- 资助金额:
$ 59.29万 - 项目类别:
The Influence Of Gut Microbiota Stability In Inflammatory Bowel Disease
肠道菌群稳定性对炎症性肠病的影响
- 批准号:
10587382 - 财政年份:2019
- 资助金额:
$ 59.29万 - 项目类别:
The Influence Of Gut Microbiota Stability In Inflammatory Bowel Disease
肠道微生物群稳定性对炎症性肠病的影响
- 批准号:
9884763 - 财政年份:2019
- 资助金额:
$ 59.29万 - 项目类别:
The relationship between host diet, the gut microbiota, and host transcription
宿主饮食、肠道微生物群和宿主转录之间的关系
- 批准号:
8808770 - 财政年份:2014
- 资助金额:
$ 59.29万 - 项目类别:
The relationship between host diet, the gut microbiota, and host transcription
宿主饮食、肠道微生物群和宿主转录之间的关系
- 批准号:
9206269 - 财政年份:2014
- 资助金额:
$ 59.29万 - 项目类别:
The relationship between host diet, the gut microbiota, and host transcription
宿主饮食、肠道微生物群和宿主转录之间的关系
- 批准号:
8605657 - 财政年份:2014
- 资助金额:
$ 59.29万 - 项目类别:
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