Uncovering the rules of gut microbiome strain transmission
揭示肠道微生物菌株传播的规则
基本信息
- 批准号:10542736
- 负责人:
- 金额:$ 59.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-01-20 至 2023-12-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdultAlgorithmsAwarenessBasic ScienceBiologicalBirthBody SurfaceChildClinicalClostridium difficileCollaborationsCommunicable DiseasesComplexComputational algorithmDataDevelopmentDiseaseDonor personEngraftmentEnvironmentFamiliarityFamilyFamily memberFecesFosteringFrequenciesGenesHealthHumanHuman MicrobiomeImmuneIndividualInfectionIntestinesKnowledgeLifeMetagenomicsMicrobeMonitorParentsPathogenesisPlayRecurrenceResearch PersonnelResourcesRoleRouteSamplingScientistSiblingsSkinSocietiesSpousesStructureTaxonTaxonomyTestingTherapeuticTimeTransplant RecipientsUlcerative ColitisVariantWorkbiobankcolonization resistancecomputer frameworkdensitydesigndisorder controldisorder preventiondisorder riskfamily structurefecal microbiomefecal transplantationgut microbesgut microbiomegut microbiotahost microbiomehost microbiotahuman diseaseimprovedmembermetagenomemicrobialmicrobial diseasemicrobiomemicrobiome compositionmicrobiome researchmicrobiotapathogenpathogenic microbetooltranslational studytransmission processwhole genome
项目摘要
PROJECT SUMMARY
As biological scientists and even as members of an educated society, we all have some familiarity with the
fundamental concept that some aspects of our health are influenced by the set of genes we obtained from our
parents. We are also increasingly aware that our body surfaces, from our skin to our intestine, harbor microbial
strains that also influence our health. Given recent discoveries that many of these microbes are stably
colonized for decades and are acquired in early life, it is perhaps unsurprising that some proportion of the
microbes inside you right now were likely acquired from your parents and/or siblings when you were a child
and maintained in your intestine to this day, potentially influencing your health for these past many years. In
addition, we have yet to find clear evidence of a commensal gut microbial strain shared between two unrelated
individuals outside of extreme circumstances of microbial transfer such as fecal microbiota transplantation.
Given the extreme uniqueness of microbial strains at the whole genome level and the rarity of each strain
variant, fecal microbiota transplantation and familial-shared microbes represent the most efficient route to
accurately track and infer basic principles of microbial transmission and sharing. We feel this study will address
an important, unaddressed gap in our basic science knowledge of the gut microbiota. Just as tracking of
classical acute pathogenic microbes plays a key role in disease prevention and treatment, uncovering the
basic principles of microbial sharing and transmission for non-acute pathogen microbes could enable new tools
to quantify disease risk, to understand the importance of the familial microbial strain sharing in disease risk, to
manipulate the gut microbiota to improve health, and ultimately perhaps to enable the prevention of disease
through controlled monitoring or therapeutic addition of microbes that limit disease risk.
项目摘要
作为生物科学家,甚至作为一个受过教育的社会的成员,我们都有一些熟悉的
一个基本的概念,我们的健康的某些方面受到我们从我们的基因组中获得的基因的影响。
父母我们也越来越意识到,我们的身体表面,从我们的皮肤到我们的肠道,
也会影响我们的健康。鉴于最近的发现,许多这些微生物是稳定的,
殖民了几十年,并在早期生活中获得,这也许是不足为奇的,
你现在体内的微生物很可能是在你还是个孩子的时候从你的父母和/或兄弟姐妹那里获得的
并在你的肠道中维持至今,在过去的许多年里可能会影响你的健康。在
此外,我们还没有找到明确的证据表明,两个无关的肠道微生物菌株之间共享
在微生物转移的极端情况之外的个体,例如粪便微生物群移植。
鉴于微生物菌株在全基因组水平上的极端独特性以及每种菌株的稀有性
变体,粪便微生物群移植和家庭共享的微生物代表了最有效的途径,
准确跟踪和推断微生物传播和共享的基本原理。我们认为这项研究将解决
这是我们对肠道微生物群的基础科学知识中一个重要的、未解决的空白。就像追踪
经典的急性病原微生物在疾病预防和治疗中起着关键作用,揭示了
非急性病原微生物的微生物共享和传播的基本原理可以使新的工具成为可能
量化疾病风险,了解家族微生物菌株在疾病风险中的重要性,
操纵肠道微生物群以改善健康,最终可能能够预防疾病
通过控制监测或治疗性添加微生物来限制疾病风险。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Jeremiah James Faith其他文献
Jeremiah James Faith的其他文献
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{{ item.author }}
{{ truncateString('Jeremiah James Faith', 18)}}的其他基金
Uncovering the rules of gut microbiome strain transmission
揭示肠道微生物菌株传播的规则
- 批准号:
10321886 - 财政年份:2020
- 资助金额:
$ 59.29万 - 项目类别:
Uncovering the rules of gut microbiome strain transmission
揭示肠道微生物菌株传播的规则
- 批准号:
9917242 - 财政年份:2020
- 资助金额:
$ 59.29万 - 项目类别:
Determination of mucosal immune responses to, and infection of the gastrointestinal tract by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
测定严重急性呼吸综合征冠状病毒 (SARS-CoV-2) 的粘膜免疫反应和胃肠道感染
- 批准号:
10179032 - 财政年份:2020
- 资助金额:
$ 59.29万 - 项目类别:
The Influence Of Gut Microbiota Stability In Inflammatory Bowel Disease
肠道菌群稳定性对炎症性肠病的影响
- 批准号:
10311993 - 财政年份:2019
- 资助金额:
$ 59.29万 - 项目类别:
The Influence Of Gut Microbiota Stability In Inflammatory Bowel Disease
肠道微生物群稳定性对炎症性肠病的影响
- 批准号:
9764766 - 财政年份:2019
- 资助金额:
$ 59.29万 - 项目类别:
The Influence Of Gut Microbiota Stability In Inflammatory Bowel Disease
肠道菌群稳定性对炎症性肠病的影响
- 批准号:
10587382 - 财政年份:2019
- 资助金额:
$ 59.29万 - 项目类别:
The Influence Of Gut Microbiota Stability In Inflammatory Bowel Disease
肠道微生物群稳定性对炎症性肠病的影响
- 批准号:
9884763 - 财政年份:2019
- 资助金额:
$ 59.29万 - 项目类别:
The relationship between host diet, the gut microbiota, and host transcription
宿主饮食、肠道微生物群和宿主转录之间的关系
- 批准号:
8808770 - 财政年份:2014
- 资助金额:
$ 59.29万 - 项目类别:
The relationship between host diet, the gut microbiota, and host transcription
宿主饮食、肠道微生物群和宿主转录之间的关系
- 批准号:
9206269 - 财政年份:2014
- 资助金额:
$ 59.29万 - 项目类别:
The relationship between host diet, the gut microbiota, and host transcription
宿主饮食、肠道微生物群和宿主转录之间的关系
- 批准号:
8605657 - 财政年份:2014
- 资助金额:
$ 59.29万 - 项目类别:
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