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Efficacy and Mechanisms of CBT4CBT for Alcohol Use Disorders

CBT4CBT 对酒精使用障碍的疗效和机制

基本信息

批准号：
9917680
负责人：
BRIAN D. KILUK
金额：
$ 55.03万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-05 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9917680
关键词：
Address Affective Alcohol consumption Ambulatory Care Behavioral Characteristics Client Clinical Cognitive Cognitive Therapy Computers Data Decision Making Empathy Evaluation Growth Heavy Drinking Individual Intervention Knowledge Link Manuals Measures Mediating Mediation Mediator of activation protein Modeling Monitor Motivation Neuropsychological Tests Online Systems Outcome Pilot Projects Play Process Randomized Randomized Controlled Trials Role Safety Short-Term Memory Supervision Testing Therapeutic TimeLine Training Urine Validation Work active method alcohol abuse therapy alcohol intervention alcohol use disorder base clinical practice cognitive function coping cost cost effective design drinking effective therapy effectiveness evaluation flexibility follow-up indexing meetings novel novel strategies programs public health relevance randomized trial reduced alcohol use response secondary outcome skill acquisition skills standard care sustained attention treatment as usual treatment effect virtual

项目摘要

DESCRIPTION (provided by applicant): Cognitive Behavioral Therapy (CBT) is an established approach for alcohol use disorders, yet it is hindered by a number of obstacles to dissemination and effective implementation in clinical practice, which include a limited understanding regarding how it exerts its effects (i.e., mechanisms of action). This proposal aims to evaluate a novel computer-based cognitive behavioral therapy program for alcohol use disorders (CBT4CBT) designed to address these obstacles. The proposed R01 project (which follows the completion of R21 AA 021405; Carroll, PI) will evaluate the efficacy of CBT4CBT or clinician-delivered CBT in comparison to standard treatment as usual (TAU) at reducing alcohol use among 180 outpatient treatment seekers. Treatments will be delivered over the course of 8-weeks and will include a 6-month follow-up period to assess durability of treatment effects. Multiple behavioral, experiential, and cognitive measures will be used to develop a more complete understanding of the mechanistic processes by which CBT works to reduce alcohol use. The specific aims of the project are as follows: 1. Evaluate the efficacy of CBT4CBT or clinician-delivered CBT relative to TAU at reducing alcohol use through an 8-week randomized trial, with 6-month follow-up. We expect either form of CBT will be more effective than TAU at increasing the percentage of days abstinent (PDA) during treatment and follow-up. 2. Evaluate the extent to which CBT's putative mechanisms act as a mediator of treatment effect on reducing alcohol use in both forms of CBT relative to TAU. We expect indices reflecting the acquisition and implementation of skills will mediate the effect of CBT on alcohol use (i.e., PDA). Exploratory aims will include the evaluation of levels of cognitive function as moderators of CBT's direct and indirect effects, as well as exploration of differences across CBT formats (clinician-delivered vs. computer- delivered) with respect to the mechanisms of action. This will be the first adequately powered randomized controlled trial to evaluate the effectiveness of a computer-delivered version of CBT as a virtual `stand-alone' intervention for alcohol use disorders, which could have clear implications for making this cost effective form of CBT more broadly accessible. Furthermore, the inclusion of traditional clinician-delivered CBT within the same trial will allow for novel examination of CBT's mechanisms, as the active ingredients can be evaluated with and without `relational' factors (e.g., therapist empathy, warmth, therapeutic alliance) that typically contribte to outcomes.

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The rise and fall of substance use during treatment: Applying recency and expectancy principles to daily substance use patterns.

治疗期间物质使用的上升和下降：将新近度和预期原则应用于日常物质使用模式。

DOI：
10.1037/adb0000824
发表时间：
2023
期刊：
Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
影响因子：
0
作者：
Benitez,Bryan;Frankforter,Tami;Nich,Charla;Kiluk,BrianD
通讯作者：
Kiluk,BrianD

The connection still matters: Therapeutic alliance with digital treatment for alcohol use disorder.

这种联系仍然很重要：与数字治疗酒精使用障碍的治疗联盟。