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Neural mechanisms of vocal communication in the human brain

人脑中声音交流的神经机制

基本信息

批准号：
9917759
负责人：
Jeremy Greenlee
金额：
$ 42.4万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-01 至 2022-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9917759
关键词：
Address Affect American Anatomy Anterior Aphasia Apraxias Area Attenuated Auditory Auditory area Behavior Behavioral Brain Brain imaging Characteristics Clinical Code Communication Complex Data Detection Development Disease Dysarthria Electric Stimulation Epilepsy Etiology Functional Magnetic Resonance Imaging Functional disorder Histologic Human Impairment Individual Knowledge Larynx Learning Life Magnetic Resonance Imaging Methods Modeling Monkeys Motor Motor Cortex Motor Pathways Pathologic Patients Pattern Physiology Play Process Production Property Public Health Quality of life Research Resolution Role Schizophrenia Sensory Signal Transduction Site Speech Structure Stuttering System Techniques Testing Work auditory feedback auditory processing autism spectrum disorder behavioral response cingulate cortex design experimental study human subject improved insight neuromechanism neurosurgery nonhuman primate novel novel therapeutics public health relevance relating to nervous system response tumor vocal control vocalization

项目摘要

DESCRIPTION (provided by applicant): Vocal communication is a vital aspect of human life. This complex behavior requires integration of the auditory feedback produced during speaking to optimize ongoing vocal production. Significant public health burden arises when vocal communication and the requisite sensorimotor integration occurring during vocalization are impaired. For example, diseases such as stuttering, aphasia, schizophrenia, and autism are felt to involve disordered sensorimotor integration. In order to develop better treatments for the millions of Americans suffering from these common diseases, it is necessary to understand the functional organization of the vocal sensorimotor brain network. Previous studies in other species suggest two parallel systems of vocal production- one involving anterior cingulate cortex (ACC) and one involving the laryngeal motor cortex (LMC). The functions of each of these areas, and the connectivity between them, are not known in humans. We will utilize complementary experimental techniques in human neurosurgery patients to overcome long-standing barriers of research progress and improve our understanding of the role of ACC and LMC in the vocal sensorimotor network. Our techniques will include functional brain imaging (MRI), high-resolution direct brain recordings, and reversible perturbation of cortical function through brain stimulation and cooling to define ACC, LMC, and auditory cortical vocalization-related physiology. We will also delineate the network connectivity between these regions. These techniques will test our hypotheses that ACC and LMC are critical to predictive coding and error detection and correction mechanisms involved in vocal control. To our knowledge, this data will be the first of its kind to directly define and test human ACC and LMC vocalization-specific responses. Such knowledge will provide mechanistic insights that cannot be obtained using other techniques and will guide development of new treatments of impaired vocal communication.