Bioanalytical and Statistics Core

生物分析和统计核心

• 批准号: 9917779
• 负责人: Daniel Joseph Tancredi
• 金额: $ 36.97万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9917779
• 关键词: Affect; Biological; Biological Assay; Biological Markers; Bioremediations; Cardiotoxicity; Cells; Chemicals; Communities; Community Health; Community Outreach; Complement; Complex Mixtures; Data; Data Analyses; Data Collection; Data Storage and Retrieval; Development; Doctor of Philosophy; Ecology; Ecosystem; Education; Educational Activities; Educational process of instructing; Ensure; Environment; Environmental Engineering technology; Environmental Pollution; Enzymes; Estrogen receptor positive; Estrogens; Experimental Designs; Exposure to; Goals; Hazardous Chemicals; Hazardous Substances; Health; Human; Human Resources; Immunoassay; Individual; Industrialization; Inherited; Instruction; Interdisciplinary Study; Knowledge; Laboratories; Lead; Measurement; Metabolic Pathway; Methods; Mission; Monitor; National Institute of Environmental Health Sciences; Pathway interactions; Pesticides; Play; Procedures; Program Evaluation; RXR; Randomized; Reproducibility; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Retinoids; Risk; Role; Ryanodine Receptors; Sampling; Services; Signal Pathway; Signal Recognition Particle; Source; Stress; Superfund; Survey Methodology; Targeted Research; Testing; Thyroid Hormones; Time; To specify; Training; Translations; Validation; Variant; Visualization; Work; analytical method; aryl hydrocarbons; base; cost effective; data quality; data standards; experience; member; portability; programs; quality assurance; rapid detection; receptor; repository; response; screening program; skills; sound; statistical service; statistics; tool; toxicant

ABSTRACT: CORE B The Bioanalytical and Statistics Core B is a centralized resource comprised of eight investigators with complementary expertise and substantial collaborative experience in understanding the impact of hazardous environmental substances on human health. Along with Core A (Analytical), Core B shares the goal of detecting biomarkers of exposure to and effect of hazardous chemicals in humans and the environment. The Core's purpose is to provide integrated, high-quality bioanalytical and statistical services to the UC Davis – NIEHS Superfund Research Program. The bioanalysis component provides a broad suite of assays, developed from the past 25 years of SRP support, to assess the presence of hazardous chemicals and/or effects of these materials on selected biological pathways. Core B inherits mature bioanalytical methods from Project 3 (Immunoassays) and the previous Project 5 (Cell-Based Assays). More than 25 immunoassays are available for various hazardous chemicals. Cell-based assays assess chemical interaction with a variety of receptors as biomarkers of effect. Most of these assays are already part of the EPA Tox21 screening program. Enzyme assays for specific pathways are also be provided by the Core. These bioanalytical methods are integral to Project 1 (Bioremediation) as they aim to identify toxic samples of human or ecosystem health concern to Core C (Community Engagement). Project 1 and Core A (Analytical) will identify toxic components of samples testing positive in bioanalysis methods, then immunoassays in this Core will be transferred to the community to build their capacity to assess the occurrence of the identified toxicant to help them determine their exposures. Projects 3 (Immunoassays), 4 (MOS and Cardiac Toxicity) and 5 (Exposure-induced ER Stress) are developing methods for Core B and as such benefit from experience provided by Core personnel that will result in valid, robust tools for exposure assessment. Core B includes four PhD-level statisticians with substantial relevant experience in collaborative multidisciplinary research. These investigators have worked with the Center's Projects and Cores to refine their proposals and to identify the research and educational activities requiring specialized statistical expertise. To facilitate effective, economical and continuous support, primary and secondary statistical consultants have been assigned to each Center Project or Core. Assignments were specified to promote an effective alignment of specialized statistical skills with the particular needs of individual Projects and Cores. The Core's quality assurance and management plans allow it to identify and respond to emerging opportunities or challenges confronting the Center, maximizing the reliability, utility and impact of the UCD SRC.

摘要：核心b 生物分析和统计核心B是八个研究人员的集中资源， 完全专业知识和实质性的合作经验，以理解危险的影响 关于人类健康的环境物质。与核心A（分析）一起，核心B共同共同 检测暴露于人类和环境中有害化学物质的生物标志物。 核心的目的是向UC Davis提供综合，高质量的生物分析和统计服务 - NIEHS超级基金研究计划。 生物分析组件提供了一系列广泛的测定，从过去25年的SRP开发 支持，评估这些材料对选定的危险化学物质的存在和/或影响 生物途径。核心B从项目3（免疫测定）和 先前的项目5（基于细胞的测定）。超过25个免疫测定可用于各种危险 化学物质。基于细胞的评估评估化学相互作用与各种接收器作为效果的生物标志物。 这些测定中的大多数已经是EPA TOX21筛选程序的一部分。特定的酶测定 路径也由核心提供。这些生物分析方法是项目1不可或缺的 （生物修复），因为它们旨在确定人类或生态系统健康问题的有毒样本，核心C （社区参与）。项目1和核心A（分析）将确定样品测试的有毒成分 在生物分析方法中，该核心的免疫测定将转移到社区中以建造 他们评估已确定的有毒物质发生的能力，以帮助他们确定其暴露。 项目3（免疫测定），4（MOS和心脏毒性）和5（暴露引起的ER应力）为 开发核心B的方法，并从核心人员提供的经验中受益，这将导致 在有效的强大工具中进行暴露评估。 核心B包括四位具有合作经验丰富相关经验的博士学位统计学家 多学科研究。这些调查人员已经与中心的项目和核心合作，以完善他们的 建议并确定需要专业统计专业知识的研究和教育活动。到 促进有效，经济和持续的支持，初级和次要统计顾问已有 被分配给每个中心项目或核心。指定任务以促进有效的一致性 专门的统计技能，具有单个项目和核心的特定需求。 核心的质量保证和管理计划使其能够识别并回应新兴 中心面临的机遇或挑战，最大化UCD的可靠性，实用性和影响 src。