Bioanalytical and Statistics Core

生物分析和统计核心

• 批准号: 10179379
• 负责人: Daniel Joseph Tancredi
• 金额: $ 49.37万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10179379
• 关键词: Affect; Biological; Biological Assay; Biological Markers; Bioremediations; Cardiotoxicity; Cells; Chemicals; Communities; Community Health; Community Outreach; Complement; Complex Mixtures; Data; Data Analyses; Data Collection; Data Storage and Retrieval; Development; Doctor of Philosophy; Ecology; Ecosystem; Education; Educational Activities; Educational process of instructing; Ensure; Environment; Environmental Engineering technology; Environmental Pollution; Enzymes; Estrogens; Experimental Designs; Exposure to; Goals; Hazardous Chemicals; Hazardous Substances; Health; Human; Human Resources; Immunoassay; Individual; Industrialization; Inherited; Instruction; Interdisciplinary Study; Knowledge; Laboratories; Lead; Measurement; Metabolic Pathway; Methods; Mission; Monitor; National Institute of Environmental Health Sciences; Pathway interactions; Pesticides; Play; Procedures; Program Evaluation; RXR; Randomized; Reproducibility; Research; Research Activity; Research Design; Research Personnel; Research Project Grants; Research Support; Resources; Retinoids; Risk; Role; Ryanodine Receptors; Sampling; Services; Signal Pathway; Signal Recognition Particle; Source; Stress; Superfund; Survey Methodology; Targeted Research; Testing; Thyroid Hormones; Time; To specify; Training; Translations; Validation; Variant; Visualization; Work; analytical method; aryl hydrocarbons; base; community engagement; cost effective; data quality; data standards; experience; member; portability; programs; quality assurance; rapid detection; receptor; repository; response; screening program; skills; sound; statistical service; statistics; tool; toxicant

ABSTRACT: CORE B The Bioanalytical and Statistics Core B is a centralized resource comprised of eight investigators with complementary expertise and substantial collaborative experience in understanding the impact of hazardous environmental substances on human health. Along with Core A (Analytical), Core B shares the goal of detecting biomarkers of exposure to and effect of hazardous chemicals in humans and the environment. The Core's purpose is to provide integrated, high-quality bioanalytical and statistical services to the UC Davis – NIEHS Superfund Research Program. The bioanalysis component provides a broad suite of assays, developed from the past 25 years of SRP support, to assess the presence of hazardous chemicals and/or effects of these materials on selected biological pathways. Core B inherits mature bioanalytical methods from Project 3 (Immunoassays) and the previous Project 5 (Cell-Based Assays). More than 25 immunoassays are available for various hazardous chemicals. Cell-based assays assess chemical interaction with a variety of receptors as biomarkers of effect. Most of these assays are already part of the EPA Tox21 screening program. Enzyme assays for specific pathways are also be provided by the Core. These bioanalytical methods are integral to Project 1 (Bioremediation) as they aim to identify toxic samples of human or ecosystem health concern to Core C (Community Engagement). Project 1 and Core A (Analytical) will identify toxic components of samples testing positive in bioanalysis methods, then immunoassays in this Core will be transferred to the community to build their capacity to assess the occurrence of the identified toxicant to help them determine their exposures. Projects 3 (Immunoassays), 4 (MOS and Cardiac Toxicity) and 5 (Exposure-induced ER Stress) are developing methods for Core B and as such benefit from experience provided by Core personnel that will result in valid, robust tools for exposure assessment. Core B includes four PhD-level statisticians with substantial relevant experience in collaborative multidisciplinary research. These investigators have worked with the Center's Projects and Cores to refine their proposals and to identify the research and educational activities requiring specialized statistical expertise. To facilitate effective, economical and continuous support, primary and secondary statistical consultants have been assigned to each Center Project or Core. Assignments were specified to promote an effective alignment of specialized statistical skills with the particular needs of individual Projects and Cores. The Core's quality assurance and management plans allow it to identify and respond to emerging opportunities or challenges confronting the Center, maximizing the reliability, utility and impact of the UCD SRC.

摘要：核心B 生物分析和统计核心B是由8名研究者组成的集中资源， 在了解危险化学品的影响方面具有互补的专门知识和丰富的合作经验 环境物质对人体健康的影响。沿着核心A（分析），核心B的共同目标是 检测人类和环境中接触危险化学品及其影响的生物标志物。的 核心的目的是提供综合，高质量的生物分析和统计服务，加州大学戴维斯分校- NIEHS超级基金研究计划。 生物分析组件提供了一套广泛的检测方法，这些方法是从SRP过去25年的发展中发展起来的。 支持，评估危险化学品的存在和/或这些材料对选定的 生物途径。核心B继承了项目3（免疫测定）的成熟生物分析方法， 项目5（基于细胞的检测）。超过25种免疫测定可用于各种危险 化学品基于细胞的测定评估与作为效应生物标志物的多种受体的化学相互作用。 这些检测中的大多数已经是EPA Tox 21筛选计划的一部分。特定的酶测定 核心也提供了途径。这些生物分析方法是项目1的组成部分 （生物修复），因为他们的目标是确定有毒样本的人类或生态系统健康的关注核心C （社区参与）。项目1和核心A（分析）将确定样品测试的有毒成分 在生物分析方法中呈阳性，则在此核心中的免疫测定将被转移到社区建立 他们评估已确定的有毒物质发生的能力，以帮助他们确定他们的接触。 项目3（免疫测定）、4（MOS和心脏毒性）和5（暴露诱导的ER应激）是 开发核心B的方法，并因此受益于核心人员提供的经验， 有效、可靠的暴露评估工具。 核心B包括四名博士级统计员，他们在协作方面具有丰富的相关经验。 多学科研究。这些研究人员与中心的项目和核心合作， 委员会还将继续努力，以确定需要专门统计知识的研究和教育活动。到 为了促进有效、经济和持续的支助，初级和二级统计顾问已 分配给每个中心项目或核心。指定了一些指标，以促进有效的协调， 专业的统计技能与个别项目和核心的特殊需求。 核心的质量保证和管理计划使其能够识别和应对新出现的 中心面临的机遇或挑战，最大限度地提高UCD的可靠性，实用性和影响力 SRC.