Comprehensive, Flexible and FAIR Tools for the HuBMAP HIVE

适用于 HuBMAP HIVE 的全面、灵活且公平的工具

• 批准号: 9920371
• 负责人: Ziv Bar-Joseph
• 金额: $ 60万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-21 至 2020-06-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9920371
• 关键词: Anatomy; Atlases; Data; Data Analyses; Deposition; Ensure; Future; Histologic; Human; Human body; Image; International; Lead; Link; Measurement; Molecular; Resolution; Tissues; Work; computerized tools; data pipeline; data portal; flexibility; programs; tool; working group

The Human BioMolecular Atlas Program (HuBMAP) will redefine our understanding of the human body by recovering multi-scale tissue organization -- anatomical, histological, and molecular, at unprecedented resolution, through computational integration of diverse experimental measurements. Our main focus in Year 2 would be gearing up for the initial HuBMAP data release expected by the end of 2020. As part of this we propose to develop and implement several computational tools and pipelines to support the various types of data that are expected to be collected including sequencing and imaging data. We would determine and develop analysis tools for the different levels of abstractions required for each data type and for the integration of several different data types. We would continue to lead several HuBMAP working groups and to interface with other international efforts to make sure that work is not duplicated while also ensuring that all tools required for HuBMAP are in available.

人类生物分子图谱计划(HuBMAP)将重新定义我们对人类的理解 通过恢复多尺度的组织结构--解剖学、组织学和分子学，在 史无前例的分辨率，通过计算集成各种实验 测量。我们在第二年的主要关注点将是为最初的HuBMAP数据发布做准备 预计到2020年底。作为这项工作的一部分，我们建议开发和实现几个 支持各种类型的数据的计算工具和管道 收集的数据包括测序和成像数据。我们将确定并开发分析工具 对于每种数据类型所需的不同抽象级别以及集成多个 不同的数据类型。我们将继续领导几个HuBMAP工作组，并与 与其他国际努力，以确保工作不重复，同时也确保 HuBMAP所需的所有工具都在中。