微生物基因组学生物医学核心-猫眼课题宝

微生物基因组学生物医学核心

批准号：

9921178

负责人：

Anne-Catrin Uhlemann

金额：

$19.19万

依托单位：

COLUMBIA UNIVERSITY HEALTH SCIENCES

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/9921178

关键词：

Acute Adherence Affect Area Bacterial Infections Bioinformatics CRISPR/Cas technology Clinical Communities Congenital Abnormality Consultations Core Facility Custom Data Analyses Disease Disease model Education Ensure Environment Event Experimental Designs Gene Expression Genes Genetic Genetic Polymorphism Genome Genomic medicine Genomics Genotype Goals Heme Homeostasis Human Individual Infection prevention Investigation Knock-in Knock-out Laboratories Life Style Medical center Medicine Mentorship Metabolic Metabolic Pathway Metagenomics Methods Microbial Genetics Microbiology Mission Modernization Mus Mutation National Institute of Diabetes and Digestive and Kidney Diseases Nucleic Acids Oligonucleotide Primers Organism Participant Pathogenesis Pathogenicity Pathology Patients Phenotype Play Policies Property RNA Reproducibility Research Research Design Research Personnel Research Project Grants Resource Sharing Resources Ribosomal RNA Role Sample Size Sampling Services Students Symptoms Technology Testing Time Universities Urinary tract infection Urine Urologic Diseases Urology Vesico-Ureteral Reflux Virulence Work base biobank cohort comparative genomics design experimental study genome analysis genome sequencing genomic tools human subject improved individual variation instrumentation interest lectures member metagenome metagenomic sequencing microbial microbiome microbiome analysis mouse model mutant next generation next generation sequencing novel pathogen pathogen genomics pathogenic microbe precision medicine programs response sample collection transcriptome sequencing urinary urologic whole genome

项目摘要

项目成果

Anne-Catrin Uhlemann的其他基金

相似基金

相关文献

中文摘要

翻译

点击翻译按钮获取中文摘要

英文摘要

MICROBIAL GENOMICS BIOMEDICAL CORE (MGBC): PROJECT SUMMARY/ABSTRACT The mission of the Columbia University O’Brien Urology Research Center is to identify genetic factors and congenital malformations that predispose individuals to UTI, such as vesicoureteral reflux, to explore host- bacterial metabolic pathways, such as heme, that enable or prevent infection. To achieve this goal, the Microbial Genomics and Biomedical Core (MGBC) will provide high quality services for biobanking, extended bacterial culture, microbial genomics (microbiome analyses, comparative genomics, RNASeq), microbial genetics and consultation for study design. The MGBC will enable Columbia O’Brien Center investigators to have access to specialized genomic technologies, coordinated expert consultations and improved rigor and reproducibility in genomics and precision medicine. These services are specifically designed to meet the needs of the Research Projects of the Columbia O’Brien Center. Moreover, the MBMC will serve as a national resource for members of other George M. O'Brien Cooperative Research Centers and other NIDDK Urologic Research Programs. Additionally, the MGBC will work closely with the Administrative Core to ensure adherence to all fiscal, administrative, and resource sharing policies. The MGBC will also contribute to the goals of the Educational Enrichment and Opportunity Pool Programs through lectures, student mentorship, and guidance on experimental design related to microbial genomics for Opportunity Pool awardees. The MBMC will accomplish these goals through the following aims: 1) Establish a urine biorepository from clinically well-defined patients with different UTI symptoms; 2) Provide Microbiome and metagenome analyses; 3) Perform extended urine culture for organism identification; 4) Facilitate whole genome sequencing of dominant UTI pathogenic clones; 5) Determine gene expression by RNAseq and quantitative real-time PCR; 6) Generate bacterial mutants; and 7) Provide consultations and support of study design for the Research Projects.

期刊论文(0)

专著(0)

科研奖励(0)

会议论文