Mast cells - bystanders or instigators of airway remodelling in asthma?

肥大细胞——哮喘气道重塑的旁观者还是煽动者？

• 批准号: nhmrc : 632830
• 负责人: A/Pr Janette Burgess
• 金额: $ 41.59万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mast-cells-bystanders-remodelling-asthma/77943
• 关键词: Mast; cells; bystanders; instigators; airway

Current asthma treatments have little effect on changes to the breathing tubes in our lungs. The tubes are thickened and stiffer, with more muscle, blood vessels, matrix and mucus. We propose that a particular inflammatory cell, called a mast cell, causes these changes to the breathing tubes and we will find out how it does that. Thus this project will establish why and how the changes to the breathing tubes happen in asthma and reveal how best to target and reverse-prevent them in the future.

目前的哮喘治疗对改变我们肺部的呼吸管几乎没有影响。管变厚变硬，有更多的肌肉、血管、基质和粘液。我们认为是一种特殊的炎症细胞，叫做肥大细胞，引起了呼吸管的这些变化，我们将找出它是如何做到的。因此，这个项目将确定哮喘患者呼吸管发生变化的原因和方式，并揭示未来如何最好地瞄准和逆转它们。