Core-005-Training

核心-005-培训

• 批准号: 9919590
• 负责人: Luoping Zhang
• 金额: $ 7.85万
• 依托单位: UNIVERSITY OF CALIFORNIA BERKELEY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9919590
• 关键词: Address; Adopted; Aromatic Polycyclic Hydrocarbons; Arsenic; Benzene; California; Chemical Exposure; Chemicals; Chromium; Collaborations; Communities; Complex; Consultations; Data Science; Detection; Disease; Engineering; Environment; Environment and Public Health; Environmental Exposure; Environmental Risk Factor; Evaluation; Exposure to; Face; Formaldehyde; Goals; Hazard Identification; Hazardous Substances; Hazardous Waste Sites; Health; Human; Laboratories; Methods; Obesity; Pathway interactions; Poison; Population; Prevention; Research; Research Personnel; Risk; Risk Assessment; Site; Stress; Superfund; Techniques; Toxic effect; Training; Translational Research; Translations; Trichloroethylene; community living; contaminated drinking water; early life exposure; environmental stressor; improved; meetings; multidisciplinary; next generation; non-genetic; novel strategies; programs; remediation; social factors; stressor; superfund site; tool

The Berkeley Superfund Research Center, in consultation with the Program’s key stakeholders, has identified four complex problems associated with hazardous waste sites that have proven intractable to current methods. These problems are how to better assess: 1) cumulative impacts from multiple environmental stressors (e.g. chemical exposures, stress and obesity); 2) past exposures, especially early-life exposures and their contribution to risk; 3) the effects of chemical mixtures and their impact on remediation efforts; and, 4) the complex transformation of chemicals to reactive intermediates and their ability to act through multiple mechanistic pathways. Here we propose six interactive projects (4 biomedical and 2 engineering) and 5 cores that aim to address these four problems though original research, translation to appropriate end-users and community engagement efforts. We will focus on exposures to high priority chemicals commonly found at Superfund sites, including arsenic, benzene, trichloroethene, formaldehyde, chromium and polycyclic aromatic hydrocarbons to address the specific mandates of the Program. We will, however, take a novel approach in adopting the so-called ‘exposome paradigm’ in our research. This new paradigm, which we helped develop, allows for a ‘seeing the whole picture’ approach to risk assessment, hazard identification and the safe and effective remediation of hazardous sites containing multiple chemicals. In the exposome paradigm all nongenetic environmental stressors are considered as environmental exposures. Therefore, cumulative risk assessment, where the impact of all stressors on a population is assessed, could be operationalized by exposomics. Communities living near sites face cumulative risks from a variety of environmental and social factors. The theme of our Center is therefore the exposome and we propose a step-wise approach to applying exposomics to help solve the complex problems found at Superfund sites. Biomedical Projects 1-4 aim to develop advanced techniques for the detection, assessment, and evaluation of the effects and risk to human health of hazardous substances; Engineering Project 5 will develop methods to detect new hazardous substances in the environment and together with Engineering Project 6 will develop methods to reduce the amount and toxicity of hazardous substances. A Community Engagement Core C (CEC) will address contaminated drinking water problems in California in collaboration with Projects 1, 5 and 6 and Core E, a Data Science and Laboratory Core that will assist researchers and the CEC in meeting their goals. A Research Translation Core C will facilitate interactions between investigators and key stakeholders and a Training Core D will develop the next generation of multidisciplinary professionals. The overall goal is to enhance understanding of the relationship between exposure and disease; provide usable tools to improve human health risk assessments; and, develop a range of prevention and remediation strategies to protect public health and the environment. The program will be overseen and coordinated by an Administration Core A.

伯克利超级基金研究中心在与该计划的主要利益攸关方协商后，确定了 与危险废物场地有关的四个复杂问题已被证明是当前方法难以解决的。 这些问题是如何更好地评估：1)多个环境应激源(例如 化学品暴露、压力和肥胖)；2)既往暴露，特别是早期暴露及其 对风险的贡献；3)化学品混合物的影响及其对补救工作的影响；以及4) 化学品向活性中间体的复杂转化及其通过多种途径发挥作用的能力 机械化的道路。在这里，我们提出了6个互动项目(4个生物医学和2个工程)和5个核心 旨在通过原创研究、翻译给适当的最终用户和 社区参与努力。我们将重点关注高优先级化学品的暴露情况，通常可在 超级基金站点，包括砷、苯、三氯乙烯、甲醛、铬和多环芳烃 碳氢化合物，以满足该方案的具体任务。然而，我们将采取一种新颖的方法 在我们的研究中采用了所谓的“暴露范式”。这是我们帮助开发的新模式， 考虑到风险评估、危险识别和安全与安全的“全景”方法 有效修复含有多种化学品的危险场所。在曝光组范式中，所有的都是非基因的 环境应激源被认为是环境暴露。因此，累积风险 评估，即评估所有应激源对人群的影响，可以通过 曝光组学。居住在工地附近的社区面临着来自各种环境和社会因素的累积风险 各种因素。因此，我们中心的主题是展示，我们提出了一种循序渐进的方法来应用 曝光组学，以帮助解决超级基金网站上发现的复杂问题。生物医学项目1-4旨在 开发先进的技术来检测、评估和评估对人类的影响和风险 危险物质的健康；工程项目5将开发检测新危险物质的方法 环境中的物质，并与工程项目6一起开发方法，以减少 危险物质的数量和毒性。社区参与核心C(CEC)将解决 加州受污染的饮用水问题，与项目1、5和6以及核心E合作，数据 科学和实验室核心，将帮助研究人员和CEC实现他们的目标。一项研究 翻译核心C将促进调查人员和主要利益相关者之间的互动，以及培训核心 D将培养下一代多学科专业人才。总体目标是加强 了解暴露与疾病之间的关系；提供有用的工具来改善人类 健康风险评估；以及制定一系列预防和补救战略，以保护公众健康 和环境。该计划将由行政核心A监督和协调。