Core-005-Training

伯克利超级基金研究中心与该计划的主要利益相关者协商， 与危险废物场地有关的四个复杂问题已被证明是目前方法难以解决的。 这些问题是如何更好地评估：1）多个环境压力源（例如， 化学品暴露，压力和肥胖）; 2）过去的暴露，特别是早期的生活暴露及其 3）化学混合物的影响及其对补救努力的影响;以及4） 化学品转化为活性中间体的复杂过程，以及它们通过多种途径发挥作用的能力。 机械路径。在这里，我们提出了六个互动项目（4个生物医学和2个工程）和5个核心 其目的是通过原始研究、翻译给适当的最终用户， 社区参与的努力。我们将重点关注暴露于常见的高优先级化学品， 超基金网站，包括砷，苯，三氯乙烯，甲醛，铬和多环芳烃 碳氢化合物，以解决该计划的具体任务。然而，我们将采取一种新颖的方法， 在我们的研究中采用了所谓的“麻烦范式”。我们帮助开发的这个新模式， 允许采用“全面了解”的方法进行风险评估、危险识别和安全， 对含有多种化学品的危险场所进行有效补救。在麻烦的范例中， 环境压力源被认为是环境暴露。因此，累积风险 评估，即评估所有压力因素对人口的影响，可以通过以下方式运作： 经济学。居住在现场附近的社区面临着各种环境和社会风险的累积 因素因此，我们中心的主题是麻烦，我们提出了一个循序渐进的方法来应用 经济学帮助解决在超级基金网站发现的复杂问题。生物医学项目1-4旨在 开发先进技术来检测、评估和评价对人类的影响和风险 有害物质的健康;工程项目5将开发检测新的有害物质的方法， 环境中的物质，并与工程项目6一起开发减少 有害物质的数量和毒性。社区参与核心C（CEC）将解决 加州的饮用水污染问题，与项目1、5和6以及核心E合作，a数据 科学和实验室核心，这将有助于研究人员和CEC实现他们的目标。一个研究 翻译核心C将促进研究者和关键利益相关者之间的互动， D将培养下一代多学科专业人员。总体目标是提高 了解接触与疾病之间的关系;提供有用的工具， 健康风险评估;以及制定一系列预防和补救战略，以保护公众健康 和环境保护该计划将由行政核心A监督和协调。

The Berkeley Superfund Research Center, in consultation with the Program’s key stakeholders, has identified four complex problems associated with hazardous waste sites that have proven intractable to current methods. These problems are how to better assess: 1) cumulative impacts from multiple environmental stressors (e.g. chemical exposures, stress and obesity); 2) past exposures, especially early-life exposures and their contribution to risk; 3) the effects of chemical mixtures and their impact on remediation efforts; and, 4) the complex transformation of chemicals to reactive intermediates and their ability to act through multiple mechanistic pathways. Here we propose six interactive projects (4 biomedical and 2 engineering) and 5 cores that aim to address these four problems though original research, translation to appropriate end-users and community engagement efforts. We will focus on exposures to high priority chemicals commonly found at Superfund sites, including arsenic, benzene, trichloroethene, formaldehyde, chromium and polycyclic aromatic hydrocarbons to address the specific mandates of the Program. We will, however, take a novel approach in adopting the so-called ‘exposome paradigm’ in our research. This new paradigm, which we helped develop, allows for a ‘seeing the whole picture’ approach to risk assessment, hazard identification and the safe and effective remediation of hazardous sites containing multiple chemicals. In the exposome paradigm all nongenetic environmental stressors are considered as environmental exposures. Therefore, cumulative risk assessment, where the impact of all stressors on a population is assessed, could be operationalized by exposomics. Communities living near sites face cumulative risks from a variety of environmental and social factors. The theme of our Center is therefore the exposome and we propose a step-wise approach to applying exposomics to help solve the complex problems found at Superfund sites. Biomedical Projects 1-4 aim to develop advanced techniques for the detection, assessment, and evaluation of the effects and risk to human health of hazardous substances; Engineering Project 5 will develop methods to detect new hazardous substances in the environment and together with Engineering Project 6 will develop methods to reduce the amount and toxicity of hazardous substances. A Community Engagement Core C (CEC) will address contaminated drinking water problems in California in collaboration with Projects 1, 5 and 6 and Core E, a Data Science and Laboratory Core that will assist researchers and the CEC in meeting their goals. A Research Translation Core C will facilitate interactions between investigators and key stakeholders and a Training Core D will develop the next generation of multidisciplinary professionals. The overall goal is to enhance understanding of the relationship between exposure and disease; provide usable tools to improve human health risk assessments; and, develop a range of prevention and remediation strategies to protect public health and the environment. The program will be overseen and coordinated by an Administration Core A.