Imaging Core

成像核心

• 批准号: 9922633
• 负责人: ARTHUR W TOGA
• 金额: $ 47.85万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9922633
• 关键词: Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease risk; Archives; Biomedical Engineering; Blood Vessels; Cerebrovascular system; Collaborations; Communities; Data; Data Collection; Dementia; Development; Early Diagnosis; Family Practice; Functional disorder; Genomics; Gerontology; Goals; Grain; Human; Hybrids; Image; Imaging Device; Imaging Techniques; Impaired cognition; MRI Scans; Magnetic Resonance Imaging; Medicine; Metabolic; Mission; Modernization; Neurology; Neurosciences; Noise; Pathogenesis; Pharmacology; Physical therapy; Physics; Physiologic pulse; Positron-Emission Tomography; Postdoctoral Fellow; Protocols documentation; Psychology; Quality Control; Research; Research Design; Research Personnel; Resources; Risk Factors; Risk Reduction; Role; Scanning; Signal Transduction; Standardization; Structure; Training; Training and Education; Vascular Cognitive Impairment; Vascular Diseases; analytical tool; base; cohort; connectome; contrast enhanced; data dissemination; data management; data quality; graduate student; neuroimaging; neurovascular; novel; open data; protocol development; recruit; repository; research study; statistics; training opportunity; vascular contributions; vascular risk factor; vector

PROJECT ABSTRACT As a part of the USC Alzheimer Disease Research Center competitive renewal, the Imaging Core will continue to serve the overall mission to provide high-quality MR and PET imaging resources to the local and broader AD research community. The ADRC Imaging Core will provide core resources, including MR physics and PET expertise, multi-scanner sequence and protocol development, image data quality control and management, research collaboration, and a global framework for conducting AD neuroimaging research. The Imaging Core is led by a well-integrated and collaborative team, including Arthur Toga (Core Leader), Judy Pa (Core Co-Leader), Meredith Braskie, Danny JJ Wang, Nasim Sheikh-Bahaei, and Paul Thompson, who together provide expertise in vascular, functional, and structural imaging and its analyses for 3T and 7T MRI, and PET. We propose 5 specific aims that provide an imaging framework for all ADRC projects; perform high quality control of all imaging data; develop technical and scientific approaches for ultra- high field 7T MRI; assist in PET protocol development and quality control; and conduct education and training in modern imaging techniques. Taken together, these goals will serve the USC ADRC’s unifying scientific theme of vascular contributions to Alzheimer disease: risk factors, neurovascular and metabolic mechanisms, and risk reduction.

项目摘要 作为南加州大学阿尔茨海默病研究中心竞争性更新的一部分，成像核心将 继续服务于整体使命，为 本地和更广泛的AD研究社区。ADRC成像核心将提供核心资源，包括 MR物理和PET专业知识、多扫描仪序列和协议开发、图像数据质量控制 和管理，研究合作，以及进行AD神经影像学研究的全球框架。 成像核心由一个整合良好的协作团队领导，包括亚瑟托加（核心负责人）， Judy Pa（核心联席负责人）、Meredith Braskie、Danny JJ Wang、Nasim Sheikh-Bahaei和Paul 汤普森，谁一起提供血管，功能和结构成像及其分析的专业知识， 3 T和7 T MRI以及PET。我们提出了5个具体目标，为所有ADRC提供了一个成像框架 项目;对所有成像数据进行高质量控制;为超 高场7 T MRI;协助PET方案制定和质量控制;以及开展教育和培训 现代成像技术。总之，这些目标将有助于南加州大学ADRC的统一科学 血管对阿尔茨海默病的贡献主题：危险因素，神经血管和代谢机制， 和降低风险。