Imaging Core

项目摘要 作为南加州大学阿尔茨海默病研究中心竞争更新的一部分，成像核心将 继续为整体使命服务，为 当地和更广泛的AD研究社区。ADRC成像核心将提供核心资源，包括 MR物理学和PET专业知识、多扫描仪序列和协议开发、图像数据质量控制 以及管理、研究协作和进行AD神经成像研究的全球框架。 影像核心由一个整合和协作良好的团队领导，包括Arthur Toga(核心领导者)， 朱迪·帕(核心联合领导人)、梅雷迪斯·布拉斯基、丹尼·JJ·王、纳西姆·谢赫-巴哈伊和保罗 汤普森共同提供血管、功能和结构成像及其分析方面的专业知识 3T、7T磁共振和正电子发射计算机断层扫描。我们提出了5个具体目标，为所有ADRC提供一个成像框架 项目；对所有成像数据进行高质量控制；开发技术和科学方法，以 高场7T核磁共振；协助PET方案的制定和质量控制；进行教育和培训 在现代成像技术中。总而言之，这些目标将服务于南加州大学ADRC统一的科学 阿尔茨海默病的血管作用主题：危险因素、神经血管和代谢机制 和降低风险。

PROJECT ABSTRACT As a part of the USC Alzheimer Disease Research Center competitive renewal, the Imaging Core will continue to serve the overall mission to provide high-quality MR and PET imaging resources to the local and broader AD research community. The ADRC Imaging Core will provide core resources, including MR physics and PET expertise, multi-scanner sequence and protocol development, image data quality control and management, research collaboration, and a global framework for conducting AD neuroimaging research. The Imaging Core is led by a well-integrated and collaborative team, including Arthur Toga (Core Leader), Judy Pa (Core Co-Leader), Meredith Braskie, Danny JJ Wang, Nasim Sheikh-Bahaei, and Paul Thompson, who together provide expertise in vascular, functional, and structural imaging and its analyses for 3T and 7T MRI, and PET. We propose 5 specific aims that provide an imaging framework for all ADRC projects; perform high quality control of all imaging data; develop technical and scientific approaches for ultra- high field 7T MRI; assist in PET protocol development and quality control; and conduct education and training in modern imaging techniques. Taken together, these goals will serve the USC ADRC’s unifying scientific theme of vascular contributions to Alzheimer disease: risk factors, neurovascular and metabolic mechanisms, and risk reduction.