Imaging Core

成像核心

基本信息

批准号：
9922633
负责人：
ARTHUR W TOGA
金额：
$ 47.85万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9922633
关键词：
Alzheimer&apos s Disease Alzheimer&apos s disease diagnosis Alzheimer&apos s disease risk Archives Biomedical Engineering Blood Vessels Cerebrovascular system Collaborations Communities Data Data Collection Dementia Development Early Diagnosis Family Practice Functional disorder Genomics Gerontology Goals Grain Human Hybrids Image Imaging Device Imaging Techniques Impaired cognition MRI Scans Magnetic Resonance Imaging Medicine Metabolic Mission Modernization Neurology Neurosciences Noise Pathogenesis Pharmacology Physical therapy Physics Physiologic pulse Positron-Emission Tomography Postdoctoral Fellow Protocols documentation Psychology Quality Control Research Research Design Research Personnel Resources Risk Factors Risk Reduction Role Scanning Signal Transduction Standardization Structure Training Training and Education Vascular Cognitive Impairment Vascular Diseases analytical tool base cohort connectome contrast enhanced data dissemination data management data quality graduate student neuroimaging neurovascular novel open data protocol development recruit repository research study statistics training opportunity vascular contributions vascular risk factor vector

项目摘要

PROJECT ABSTRACT As a part of the USC Alzheimer Disease Research Center competitive renewal, the Imaging Core will continue to serve the overall mission to provide high-quality MR and PET imaging resources to the local and broader AD research community. The ADRC Imaging Core will provide core resources, including MR physics and PET expertise, multi-scanner sequence and protocol development, image data quality control and management, research collaboration, and a global framework for conducting AD neuroimaging research. The Imaging Core is led by a well-integrated and collaborative team, including Arthur Toga (Core Leader), Judy Pa (Core Co-Leader), Meredith Braskie, Danny JJ Wang, Nasim Sheikh-Bahaei, and Paul Thompson, who together provide expertise in vascular, functional, and structural imaging and its analyses for 3T and 7T MRI, and PET. We propose 5 specific aims that provide an imaging framework for all ADRC projects; perform high quality control of all imaging data; develop technical and scientific approaches for ultra- high field 7T MRI; assist in PET protocol development and quality control; and conduct education and training in modern imaging techniques. Taken together, these goals will serve the USC ADRC’s unifying scientific theme of vascular contributions to Alzheimer disease: risk factors, neurovascular and metabolic mechanisms, and risk reduction.

项目摘要作为USC阿尔茨海默氏病研究中心竞争性更新的一部分，成像核心将继续服务于整体使命，向高质量的MR和PET成像资源提供给本地和更广泛的广告研究社区。 ADRC成像核心将提供核心资源，包括 MR物理学和宠物专业知识，多扫描仪序列和协议开发，图像数据质量控制以及管理，研究合作以及进行AD神经影像研究的全球框架。成像核心由一个整合和协作的团队领导，包括Arthur Toga（核心负责人），朱迪·帕（Judy Pa）（核心联合领导者），梅雷迪思·布拉斯基（Meredith Braskie），丹尼·贾（Danny JJ Wang），纳西姆·谢赫·巴哈伊（Nasim Sheikh-Bahaei）和保罗汤普森（Thompson）共同提供有关血管，功能和结构成像及其分析的专业知识 3T和7T MRI，以及宠物。我们提出了5个具体目标，可为所有ADRC提供成像框架项目；对所有成像数据进行高质量控制；开发超级技术和科学方法高场7T MRI;协助宠物协议开发和质量控制；并进行教育和培训在现代成像技术中。综上所述，这些目标将为USC ADRC的统一科学服务血管贡献对阿尔茨海默氏病的主题：危险因素，神经血管和代谢机制，和降低风险。