Training in the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer’s Disease

阿尔茨海默病生物标志物的多尺度和多模式分析培训

• 批准号: 10628648
• 负责人: ARTHUR W TOGA
• 金额: $ 17.53万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628648
• 关键词: Alzheimer' s Disease; Biological Markers; Training; multimodality

PROJECT SUMMARY/ABSTRACT Recognizing the critical need for a broad range of expertise in biomarker analysis at several levels of analysis, we propose a unique postdoctoral training program titled “Training for the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer’s Disease” (AD). USC is home to leading experts who utilize biomarkers in their work investigating AD through a myriad of methods and analyses. Drawing from USC’s eminent resources and expertise, this proposal will focus on preparing investigators for independent research careers in the multiscale and multimodal analysis of biomarkers in AD, by integrating molecular and cellular methods, imaging tools and informatics, quantitative methods for clinical trials research, and large-scale population analyses. Our proposed training program draws preceptors and faculty from 12 schools, departments, institutes, and centers at USC, fulfilling these methodological areas of expertise: USC Mark and Mary Stevens Neuroimaging and Informatics Institute (INI) in the Keck School of Medicine (KSoM); Zilkha Neurogenetic Institute (ZNI) in the KSoM; Department of Neurology in the KSoM; Department of Neurological Surgery in the KSoM; Department of Radiology in KSoM; Alzheimer's Therapeutic Research Institute in the KSoM; Department of Population and Public Health Sciences at the KSoM; Department of Economics in the Dana and David Dornsife College of Letters, Arts and Sciences; Center for Economic and Social Research in the Dana and David Dornsife College of Letters, Arts and Sciences; Institute for Technology and Medical Systems Innovation (ITEMS), a joint initiative between Keck School of Medicine and Viterbi School of Engineering; Leonard D. Schaeffer Center for Health Policy and Economics, a unique collaboration between the USC Sol Price School of Public Policy and School of Pharmacy; and Leonard Davis School of Gerontology. Trainees will complete coursework, lab rotations, and career development activities, such as seminar series, instruction for problem solving, communication, time management, and leadership skills, and instruction and training in grant writing. Trainees will become conversant in all thematic areas and will be able to effectively collaborate outside of their own particular area of expertise. Specifically, the USC Training for the Multiscale and Multimodal Analysis of Biomarkers in AD will aim to: equip trainees with a combination of skills to conduct multiscale and multimodal analyses of biomarkers in AD by providing tailored, didactic research education opportunities to further the research potential of trainees; facilitate eminent research in the multiscale and multimodal analysis of biomarkers in AD by trainees, including the development of research ideas, execution of research projects, and dissemination of research findings; establish among trainees a collaborative and multidisciplinary team approach to advance research in the multiscale and multimodal analysis of biomarkers in AD; and successfully transition trainees to independent research careers, including securing their own research funding.

项目摘要/摘要 认识到在几个分析层面上对生物标记物分析方面的广泛专业知识的迫切需要， 我们提出了一个独一无二的博士后培训计划，名为《多尺度多模式分析培训》。 阿尔茨海默病中的生物标记物“(AD)。南加州大学聚集了在工作中使用生物标记物的顶尖专家 通过各种方法和分析调查AD。借鉴南加州大学卓越的资源和 专业知识，这项提议将侧重于为多尺度的独立研究职业生涯做好准备 和多模式分析的生物标志物在AD，通过分子和细胞方法，成像工具和 信息学、临床试验研究的定量方法和大规模人口分析。我们的建议 培训计划吸引了来自南加州大学12所学校、系、研究所和中心的教师和教职员工， 实践这些专业领域的方法论：南加州大学马克和玛丽·史蒂文斯神经成像和信息学 Keck医学院的Zilkha神经发生研究所(ZNI)； KSoM神经科；KSoM神经外科 KSoM的放射学；KSoM的阿尔茨海默病治疗研究所； 达纳和大卫·多恩西夫学院经济系公共卫生科学 文学、艺术和科学；达纳和大卫·多恩西夫学院经济和社会研究中心 文学、艺术和科学研究所；技术和医疗系统创新研究所(项目)，一项联合倡议 凯克医学院和维特比工程学院之间；伦纳德·D·谢弗健康中心 政策与经济，南加州大学索尔普赖斯公共政策学院和南加州大学公共政策学院之间的独特合作 药学和伦纳德·戴维斯老年学学院。实习生将完成课程作业、实验室轮换和 职业发展活动，如系列研讨会、解决问题的指导、沟通、时间 管理、领导技能，以及赠款撰写方面的指导和培训。实习生将变得熟悉 在所有专题领域开展合作，并将能够在各自特定的专门领域之外进行有效协作。 具体地说，南加州大学针对AD中生物标志物的多尺度和多模式分析的培训将旨在：装备 具备多种技能的受训人员将通过以下方式对AD中的生物标记物进行多尺度和多模式分析 提供因材施教的研究教育机会，以促进学员的研究潜力；促进 受训人员在AD生物标志物多尺度和多模式分析方面的杰出研究，包括 发展研究思路，执行研究项目，传播研究成果；建立 在受训人员中，采用协作和多学科团队的方法来推进多尺度和 AD中生物标志物的多模式分析；并成功地将受训人员过渡到独立的研究职业， 包括确保他们自己的研究资金。

项目成果

Brain structural correlates of insomnia severity in 1053 individuals with major depressive disorder: results from the ENIGMA MDD Working Group.

• DOI: 10.1038/s41398-020-01109-5
• 发表时间: 2020-12-08
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Leerssen J;Blanken TF;Pozzi E;Jahanshad N;Aftanas L;Andreassen OA;Baune BT;Brack I;Carballedo A;Ching CRK;Dannlowski U;Dohm K;Enneking V;Filimonova E;Fingas SM;Frodl T;Godlewska BR;Goltermann J;Gotlib IH;Grotegerd D;Gruber O;Harris MA;Hatton SN;Hawkins E;Hickie IB;Jaworska N;Kircher T;Krug A;Lagopoulos J;Lemke H;Li M;MacMaster FP;McIntosh AM;McLellan Q;Meinert S;Mwangi B;Nenadić I;Osipov E;Portella MJ;Redlich R;Repple J;Sacchet MD;Sämann PG;Simulionyte E;Soares JC;Walter M;Watanabe N;Whalley HC;Yüksel D;Veltman DJ;Thompson PM;Schmaal L;Van Someren EJW
• 通讯作者: Van Someren EJW