Training for the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer's Disease

项目摘要/摘要 认识到在几个分析层面上对生物标记物分析方面的广泛专业知识的迫切需要， 我们提出了一个独一无二的博士后培训计划，名为“多尺度和多模式分析培训” 生物标记物在阿尔茨海默病中的作用“(AD)。南加州大学聚集了一流的专家，他们在他们的 通过各种方法和分析调查AD的工作。借鉴南加州大学卓越的资源和 专业知识，这项提议将侧重于为多尺度的独立研究职业生涯做好准备 和多模式分析的生物标志物在AD，通过分子和细胞方法，成像工具和 信息学、临床试验研究的定量方法和大规模人口分析。我们的建议 培训计划吸引了来自南加州大学六所学校、系、研究所和中心的教师和教职员工， 实现这些专业领域的方法论：马克和玛丽·史蒂文斯的神经成像和信息学 凯克医学院(INI)；维特比生物医学工程系(BME) 凯克医学院Zilkha神经发生研究所； 《达纳和大卫·多恩西夫文学、艺术和科学学院的心理学》 卫生政策和经济中心，南加州大学索尔普斯公共学院之间的独特合作 政策和药学院；以及伦纳德·戴维斯老年学学院。学员将完成课程作业， 实验室轮换和职业发展活动，如系列研讨会、解决问题指导、 沟通、时间管理和领导技能，以及拨款撰写方面的指导和培训。实习生 将熟悉所有主题领域，并将能够在自己的领域之外进行有效的协作 特定的专业领域。具体地说，南加州大学的多尺度和多模式分析培训 AD的生物标记物将致力于：使受训人员具备进行多规模和多模式操作的综合技能 通过提供量身定制的教学研究教育机会来分析AD的生物标志物，以进一步 学员的研究潜力；促进在多尺度和多模式分析方面的杰出研究 受训者在AD中的生物标志物，包括研究想法的发展，研究项目的执行，以及 传播研究成果；在受训人员中建立一个协作和多学科小组 推进AD生物标志物的多尺度和多模式分析研究的方法；并成功 将受训人员过渡到独立的研究职业，包括获得自己的研究资金。

PROJECT SUMMARY/ABSTRACT Recognizing the critical need for a broad range of expertise in biomarker analysis at several levels of analysis, we propose a unique postdoctoral training program titled “Training for the Multiscale and Multimodal Analysis of Biomarkers in Alzheimer's Disease” (AD). USC is home to leading experts who utilize biomarkers in their work investigating AD through a myriad of methods and analyses. Drawing from USC's eminent resources and expertise, this proposal will focus on preparing investigators for independent research careers in the multiscale and multimodal analysis of biomarkers in AD, by integrating molecular and cellular methods, imaging tools and informatics, quantitative methods for clinical trials research, and large scale population analyses. Our proposed training program draws preceptors and faculty from six schools, departments, institutes, and centers at USC, fulfilling these methodological areas of expertise: Mark and Mary Stevens Neuroimaging and Informatics Institute (INI) in the Keck School of Medicine; Department of Biomedical Engineering (BME) in the Viterbi School of Engineering; Zilkha Neurogenetic Institute (ZNI) in the Keck School of Medicine; Department of Psychology in the Dana and David Dornsife College of Letters, Arts and Sciences; Leonard D. Schaeffer Center for Health Policy and Economics, a unique collaboration between the USC Sol Price School of Public Policy and School of Pharmacy; and Leonard Davis School of Gerontology. Trainees will complete coursework, lab rotations, and career development activities, such as seminar series, instruction for problem solving, communication, time management, and leadership skills, and instruction and training in grant writing. Trainees will become conversant in all thematic areas and will be able to effectively collaborate outside of their own particular area of expertise. Specifically, the USC Training for the Multiscale and Multimodal Analysis of Biomarkers in AD will aim to: equip trainees with a combination of skills to conduct multiscale and multimodal analyses of biomarkers in AD by providing tailored, didactic research education opportunities to further the research potential of trainees; facilitate eminent research in the multiscale and multimodal analysis of biomarkers in AD by trainees, including the development of research ideas, execution of research projects, and dissemination of research findings; establish among trainees a collaborative and multidisciplinary team approach to advance research in the multiscale and multimodal analysis of biomarkers in AD; and successfully transition trainees to independent research careers, including securing their own research funding.