Data Management and Statistical Core

摘要 数据管理和统计(DMS)核心的主要目标是提供数据 对华盛顿大学核心项目及其附属项目的管理和统计支持 阿尔茨海默病研究中心(UW ADRC)。DMS核心计算机与数据管理 专家构建、修改和维护存储、集成和访问UW所需的数据库 ADRC跨核心和来自外部来源的数据，同时确保最新的计算机安全。他们写道 在个人计算机和数据库之间实现无缝集成和数据流的代码 实验室，以及开发新的计算机工具和电子数据捕获和数据共享程序。 他们协调所有数据流和数据更正；进行数据质量控制和质量保证 分析；与其他核心合作进行必要的数据更正，并将数据提交给国家 阿尔茨海默病协调中心与其他研究人员共享。他们还开发数据 表示和数据访问程序，并与其他核心协作以获取数据的属性 用于数据查询的。DMS核心统计师适用于所有核心、开发项目和 关于统计设计、分析和解释的咨询和援助附属项目 数据，并启动新的协作。他们还协助准备手稿，并在需要时， 评估、开发和/或实施新的分析方法作为工作软件。 具体目标是：(1)为项目、核心、附属项目和 发展项目。这包括确保所有临床核心数据的数据库录入；及时上传临床、 神经病理学，并向NACC提供定向基因分型数据；跟踪和监测数据完成和 质量；核心之间数据流的协调；数据校正的协调和处理；开发 数据提取工具的使用；数据库的维护和继续开发。(2)提供 UW ADRC的项目、核心、开发项目和附属项目的统计支持。这将是 包括就设计、分析和解释结果提供统计咨询；进行数据 分析；协助编写相关手稿；评估和推广统计 方法论。(3)维持实现目标1和目标2所需的计算环境。 UW ADRC的数据管理和统计核心将提供必要的数据管理 高效、准确地存储和检索中心收集的数据所需的协助。穿过 协助统计数据分析，还将促进将数据转化为科学发现 与阿尔茨海默病的预防、治疗或诊断有关。在此过程中，DMS核心将 促进华盛顿大学ADRC减轻阿尔茨海默氏症负担的总体目标的实现。

Abstract The primary objectives of the Data Management and Statistics (DMS) Core are to provide data management and statistical support to the cores and affiliated projects of the University of Washington Alzheimer's Disease Research Center (UW ADRC). The DMS Core computer and data management specialists construct, modify, and maintain the databases needed to store, integrate, and access the UW ADRC data across cores and from outside sources, while ensuring up-to-date computer security. They write the code for seamless integration and data flow between computers and databases that are in the individual laboratories, and for developing new computer tools and electronic data capture and data sharing procedures. They coordinate all data flow and data corrections; carry out data quality control and quality assurance analyses; collaborate with other cores to make necessary data corrections, and submit data to the National Alzheimer's disease Coordinating Center for sharing with other investigators. They also develop data representations and data access procedures, and collaborate with other cores to derive attributes of the data that are used for data queries. The DMS Core statisticians are available to all cores, development projects, and affiliated projects for consultation and assistance regarding statistical design, analysis, and interpretation of data, and to initiate new collaborations. They also assist in manuscript preparation and, when needed, evaluate, develop and/or implement new analytical methodology as working software. The specific aims are: (1) To provide data management support for projects, cores, affiliated projects and development projects. This includes ensuring database entry of all Clinical Core data; timely upload of clinical, neuropathology, and targeted genotyping data to NACC; tracking and monitoring of data completion and quality; coordination of data flow between cores; coordinating and processing of data corrections; development of data extraction tools; and maintenance and continued development of the databases. (2) To provide statistical support for projects, cores, development projects and affiliated projects of the UW ADRC. This will include providing statistical consultation on design, analysis, and interpretation of results; carrying out data analyses; assisting with associated manuscript preparation; and evaluating and extending statistical methodologies. (3) To maintain the computing environment needed to achieve aims 1 and 2. The Data Management and Statistics Core of the UW ADRC will provide the necessary data management assistance needed to efficiently and accurately store and retrieve the data collected by the center. Through assistance with statistical data analysis it will also facilitate the translation of data into scientific discoveries relevant to the prevention, treatement or diagnosis of Alzheimer's disease. In doing so, the DMS Core will facilitate the overall goals of the UW ADRC in its mission toward reducing the burden of Alzheimer's disease.