Origins of Renal Physiology

项目摘要/摘要 MDI生物实验室寻求NIDDK R25的支持，第九届通过第十三届年度产品的一个- 肾脏研究员的一周课程，肾脏生理学的起源。该课程将于9月的第一周举行 2017年至2021年在MDI生物实验室校园，在巴尔港，缅因州。拟议的课程 为肾脏研究员提供有关体内平衡基本概念的实践研究教育， 这些实验是肾脏生理学和肾脏病学的基础。七道菜 提出了模块：肾小球滤过，近端小管功能，粗升支协同转运蛋白，盐 分泌和平衡、集合管钠转运/ENaC、水稳态和酸/碱 体内平衡七个模块中的每一个都以连续三天的轮换（星期一至星期二， 星期三至星期四和星期五至星期六），每次轮换的第一天都涉及密集的实验性训练。 第二天是分析和向整个课程组介绍工作。每个 参加者将在三次轮调期间完成六个计划单元中的三个。基于案例研究的 在研究程序的负责任行为将在每次轮换之前。肾脏生理学的起源完全是 在全国肾脏短期课程中独一无二。该课程为参与者提供研究工具， 更深入地理解生理稳态的概念，这在正常情况下很难实现。 临床培训时间表。该课程向肾脏研究员开放，自2010年以来，在有空位的基础上， 内科住院医生进入肾病科研究员和居民都受益于与高级的密切互动 肾生理学的研究者，他们领导课程模块。居民，特别是受益于与 来自不同项目的研究员，分享他们对肾脏研究和肾脏病学的见解。该课程是 在MDI生物实验室网站（http：//www.example.com）上和在J. Am. www.mdibl.org Soc.肾脏病学（Zeidel等人，J.J. 19：649-50，2008）。申请的资金将用于支付课程学费， 参与者差旅费;教师生活费、津贴和差旅费;设施使用费;顾问服务;以及 管理研究教育计划所需的人员费用。

Project Summary / Abstract MDI Biological Laboratory seeks NIDDK R25 support for the ninth through thirteenth annual offerings of a one- week course for renal fellows, Origins of Renal Physiology. The course will be held the first week of September 2017 through 2021 on the MDI Biological Laboratory campus, in Bar Harbor, Maine. The proposed course provides renal fellows with hands-on research education in fundamental concepts of homeostasis and exposes them to the classical experiments that form the foundation of renal physiology and nephrology. Seven course modules are proposed: glomerular filtration, proximal tubule function, thick ascending limb cotransporters, salt secretion and balance, collecting duct sodium transport /ENaC, water homeostasis, and acid/base homeostasis. Each of the seven modules runs in three consecutive two-day rotations (Monday-Tuesday, Wednesday-Thursday, and Friday-Saturday), with the first day of each rotation involving intensive experimental work, and the second day involving analysis and presentation of the work to the entire course group. Each participant will complete three of the six planned modules during the three rotations. A case study-based Responsible Conduct in Research program will precede each rotation. Origins of Renal Physiology is entirely unique among national renal short courses. The course provides participants with research tools that give them a deeper understanding of concepts of physiological homeostasis which is difficult to attain during normal clinical training schedules. The course is open to renal fellows and, since 2010, on a space-available basis, medical residents entering nephrology. Fellows and residents alike benefit from close interactions with senior investigators in renal physiology who lead the course modules. Residents, in particular, benefit by working with fellows from different programs and sharing their insights into renal research and nephrology. The course is described on the MDI Biological Laboratory website (http://www.mdibl.org), and in a recent editorial in J. Am. Soc. of Nephrology (Zeidel et al., JASN 19: 649-50, 2008). Requested funds will cover course tuition and participant travel; faculty subsistence, stipends, and travel; facility user fees; consultant services; and personnel costs required to administer the research education program.