Spinal circuits for mechanical itch and light touch
机械性瘙痒和轻触的脊髓回路
基本信息
- 批准号:9924686
- 负责人:
- 金额:$ 119.42万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-01 至 2027-04-30
- 项目状态:未结题
- 来源:
- 关键词:AnimalsBehaviorBehavioral AssayCellsComplementDorsalFeedbackForelimbGoalsHumanInterneuronsLightLimb structureMapsMechanicsModelingMotorMotor ActivityMovementNeuronsPathway interactionsPlayPopulationPruritusReflex actionReporterRoleRunningSensorySpinalSpinal CordSpinal cord injurySynapsesSystemTouch sensationWalkingWithdrawalcell typechronic itchgenetic manipulationgraspimprovedinsightmotor behaviormotor controlmotor disordermouse geneticsnovel strategiesoptogeneticspainful neuropathysensory feedbackspinal reflextransmission process
项目摘要
Animals and humans display a vast repertoire of behaviors, many of which are generated by motor
networks in the spinal cord. This coordinated spinal motor activity is strongly regulated by descending
motor control pathways and sensory afferent feedback. Sensory feedback is essential for both
stereotypical protective reflexes, such as limb withdrawal, and for regulating ongoing motor behaviors,
such as walking, running, and reaching. Interestingly, many descending motor control pathways converge
on interneurons in the dorsal spinal cord that transmit sensory information, indicating a prominent role for
these cells in motor control. Currently, very little is known about how sensorimotor networks in the spinal
cord are organized at a cellular level. Efforts proposed here will use cutting-edge genetic manipulations
and sensitive behavioral assays to deconstruct the cellular composition and synaptic connectivity of these
sensorimotor circuits. The goals of this study are to functionally define the neuronal cell types that make
up the sensorimotor circuitry and to generate a connectivity map that can then be used to construct a
working model of how the sensorimotor circuitry is organized. Intersectional mouse genetics will be used
to target specific populations of spinal neurons and ask whether inactivating or activating them with
chemogenetic and optogenetic reporters perturbs specific sensorimotor pathways, including those that
generate corrective behaviors during ongoing movement and noxious mechanical pathways that induce
protective reflexes. Studies of protective and corrective reflexes will be complemented with an analysis of
the sensory circuitry for the control of forelimb reaching and grasping behaviors. These studies, when
completed, will provide new insights into the organization of the spinal reflex circuitry, and improve our
understanding of the cellular computations that underlie sensorimotor transformation in the spinal cord.
动物和人类表现出大量的行为,其中许多是由运动产生的
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Martyn D Goulding其他文献
Martyn D Goulding的其他文献
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{{ truncateString('Martyn D Goulding', 18)}}的其他基金
Spinal Circuits for the Control of Dextrous Movement
控制灵巧运动的脊髓回路
- 批准号:
10226037 - 财政年份:2019
- 资助金额:
$ 119.42万 - 项目类别:
Spinal Circuits for the Control of Dextrous Movement
控制灵巧运动的脊髓回路
- 批准号:
9815384 - 财政年份:2019
- 资助金额:
$ 119.42万 - 项目类别:
Spinal circuits for mechanical itch and light touch
机械性瘙痒和轻触的脊髓回路
- 批准号:
10624793 - 财政年份:2019
- 资助金额:
$ 119.42万 - 项目类别:
Spinal Circuits for the Control of Dextrous Movement
控制灵巧运动的脊髓回路
- 批准号:
10011906 - 财政年份:2019
- 资助金额:
$ 119.42万 - 项目类别:
Spinal Circuits for the Control of Dextrous Movement
控制灵巧运动的脊髓回路
- 批准号:
10696186 - 财政年份:2019
- 资助金额:
$ 119.42万 - 项目类别:
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