Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM)
针对语言能力极低的自闭症儿童的个性化、响应式干预序列 (PRISM)
基本信息
- 批准号:9925806
- 负责人:
- 金额:$ 64.4万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-05-05 至 2024-02-29
- 项目状态:已结题
- 来源:
- 关键词:4 year oldAddressAgeAreaChildChild LanguageClassificationCommunicationConsensusDiseaseEarly InterventionEducational workshopElementsExhibitsExposure toGoalsHeterogeneityIndividualInterventionIntervention StudiesJointsKnowledgeLanguageMeasuresMediatingMediator of activation proteinNational Institute of Mental HealthNursery SchoolsOregonOutcomeParticipantPlayPopulationPreschool ChildProbabilityRegulationResearchRiskSchool-Age PopulationSiteSpecific qualifier valueSpeechStrategic PlanningTerminologyTestingTimeTrainingUnited States National Institutes of Healthadaptive interventionagedapplied behavior analysisautism spectrum disorderautistic childrenbasecommunity settingdesignevidence basefollow-upimprovedjoint attentionlanguage outcomepersonalized interventionphrasesprimary outcomeresearch studyresponsesecondary outcomeskillssocialsocial communication impairmentstandard of caretherapy design
项目摘要
PROJECT ABSTRACT
Many 3-4 year olds with autism spectrum disorder (ASD) who are `preverbal' (30-50%) do not go on
to develop socially related words and phrases by age 5-6 years and are reclassified as `minimally verbal',
never moving past 20 functional, non-echoed words, even with exposure to evidence-based early
interventions. Despite significant research of children older than 5 who are already classified as minimally
verbal, little research has attempted to optimize intervention for limited language preschool children who
may be more likely to develop language with appropriate, targeted, and personalized intervention
approaches. Therefore, a major gap in our knowledge remains on how to place these children with ASD on
a path to becoming verbal by school age, thus reducing the numbers of minimally verbal children. A key
challenge in this population is that one size does not fit all: there is vast heterogeneity in presentation and
response to intervention. To capitalize on this heterogeneity, it will be necessary to use an individually
tailored, sequential approach to intervention whereby treatment is adapted over time based on how the child
responds. The overarching goal of the proposed multi-site project is to maximize language outcomes for
preschoolers at risk for maintaining `minimally verbal' status by developing a two-stage, 20-week “adaptive
intervention” (an intervention that incorporates a replicable sequence of treatment decision rules to guide
clinicians on when and how to alter an intervention). This study addresses key questions in designing an
adaptive intervention, including how best to intervene with children responding slowly to initial intervention,
which of four pre-specified adaptive interventions is best, which moderators are important to designing a
more individually tailored adaptive intervention, and better understanding the mechanism by which the
adaptive interventions may exhibit their effects. Specifically, the primary aim tests the effect of intensifying
stage 1 singular interventions versus changing intervention by systematically combining and enhancing
treatment modules. The stage 1 interventions include a commonly recommended approach based on
applied behavior analysis (discrete trial training) and an evidence-based early intervention that specifically
addresses the social communication impairment in ASD, JASPER (Joint Attention Symbolic Play
Engagement & Regulation). The primary outcome is spontaneous communicative utterances, and
secondary outcomes include joint engagement, receptive language, and presence of word combinations.
Our secondary and exploratory aims include moderator and mediator tests, and longitudinal outcome at age
5-6 years. Child participants include 140 4-year-olds with ASD and limited language (<20 functional words)
across 3 sites (U Oregon, Rochester, and UCLA). This study has the potential to dramatically improve
communication outcomes for children with ASD, and addresses a high priority need of the Interagency
Autism Coordinating Council and NIH.
项目摘要
许多患有自闭症谱系障碍(ASD)的3-4岁奥尔兹(30-50%)"无法言语“,
在5-6岁时发展与社会有关的词汇和短语,并被重新归类为“最低限度的语言”,
从未超过20个功能性的,无回声的单词,即使在早期接触循证医学,
干预措施。尽管对5岁以上的儿童进行了大量研究,
很少有研究试图优化对语言有限的学龄前儿童的干预,
通过适当的、有针对性的和个性化的干预,
接近。因此,我们知识的一个主要空白仍然是如何将这些ASD儿童安置在
一条在学龄前学会说话的道路,从而减少语言能力最低的儿童的数量。一个关键
这一人群面临的挑战是,一种尺寸并不适合所有人:表现存在巨大的异质性,
对干预的回应。为了利用这种异质性,有必要单独使用
量身定制的连续干预方法,根据儿童的
回答。拟议的多地点项目的总体目标是最大限度地提高语文成果,
学龄前儿童在风险维持“最低限度的语言”的地位,通过发展一个两阶段,20周的“适应性”
干预”(一种干预,包括一系列可复制的治疗决策规则,以指导
临床医生何时以及如何改变干预)。这项研究解决了设计一个
适应性干预,包括如何最好地干预对初始干预反应缓慢的儿童,
四个预先指定的适应性干预措施中哪一个是最好的,哪些主持人对设计一个
更个性化的适应性干预,更好地了解
适应性干预可能会产生效果。具体来说,主要目的是测试强化的效果,
第一阶段:单一干预措施与不断变化的干预措施,
治疗模块。第1阶段的干预措施包括一种普遍推荐的方法,
应用行为分析(离散试验培训)和基于证据的早期干预,
解决了ASD的社会沟通障碍,碧玉(联合注意力符号游戏
参与和监管)。主要结果是自发的交际话语,
次要结果包括联合参与、接受性语言和单词组合的存在。
我们的次要和探索性目标包括调节和中介测试,以及年龄的纵向结果。
5-6年儿童参与者包括140名患有ASD和语言受限(<20个功能词)的4岁儿童
3个研究中心(U俄勒冈州、罗切斯特和UCLA)。这项研究有可能极大地改善
为ASD儿童提供沟通成果,并解决机构间的高度优先需求
自闭症协调理事会和NIH。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CONNIE L. KASARI其他文献
CONNIE L. KASARI的其他文献
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{{ truncateString('CONNIE L. KASARI', 18)}}的其他基金
PETAL: Promoting Early Intervention Timing and Attention to Language
PETAL:促进早期干预时机和对语言的关注
- 批准号:
10568487 - 财政年份:2023
- 资助金额:
$ 64.4万 - 项目类别:
Predicting and Optimizing Language Outcomes in Minimally Verbal Children with Autism Spectrum Disorder
预测和优化患有自闭症谱系障碍的最低限度语言儿童的语言结果
- 批准号:
10470952 - 财政年份:2019
- 资助金额:
$ 64.4万 - 项目类别:
BLOOM: Boosting Language Outcomes of Minimally Verbal Children with ASD
BLOOM:提高自闭症谱系障碍儿童的语言能力
- 批准号:
10689723 - 财政年份:2019
- 资助金额:
$ 64.4万 - 项目类别:
BLOOM: Boosting Language Outcomes of Minimally Verbal Children with ASD
BLOOM:提高自闭症谱系障碍儿童的语言能力
- 批准号:
10470955 - 财政年份:2019
- 资助金额:
$ 64.4万 - 项目类别:
BLOOM: Boosting Language Outcomes of Minimally Verbal Children with ASD
BLOOM:提高自闭症谱系障碍儿童的语言能力
- 批准号:
10001018 - 财政年份:2019
- 资助金额:
$ 64.4万 - 项目类别:
Community-based Adaptive autism Intervention for Toddlers
基于社区的幼儿适应性自闭症干预
- 批准号:
9923036 - 财政年份:2019
- 资助金额:
$ 64.4万 - 项目类别:
Predicting and Optimizing Language Outcomes in Minimally Verbal Children with Autism Spectrum Disorder
预测和优化患有自闭症谱系障碍的最低限度语言儿童的语言结果
- 批准号:
10689688 - 财政年份:2019
- 资助金额:
$ 64.4万 - 项目类别:
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