ConProject-002

ConProject-002

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT A significant number of children with ASD remain minimally verbal even after receiving quality interventions. Recent studies have highlighted the heterogeneity of this group confirming that no single mechanism can explain the underlying causes of their severe communication deficits. At the same time, innovative targeted behavioral interventions can lead to improvements in speech and social communication in some minimally verbal children. The goals of this Center, located at Boston University and University of California Los Angeles, are to build on our earlier work addressing a central theme: Which young minimally verbal children with ASD make gains acquiring language during the early school years and how can we facilitate such progress? We approach these questions from a multidisciplinary perspective, employing tools, methods, and approaches drawn from communication disorders, speech and motor science, developmental neuroscience, genetics and interventions research. The four interconnected projects address the following aims. Aim 1: To identify motor and neural mechanisms underlying the profound spoken language impairments that define minimally verbal children with autism. In two projects on the same group of young minimally verbal children we plan to characterize oral and general motor functioning using state-of- the-art technologies, and electrophysiology to probe neural functioning (Project 1, 2). Aim 2: To advance our understanding of how to optimize the language outcomes of young minimally verbal children with ASD. We address this by carrying out a randomized controlled trial of a behavioral intervention that combines social communication and oromotor targets (Project 3) and by following the children studied in Aim 1 for two years to explore how changes in motor and neural functioning may predict diverse language pathways (Projects 1, 2). Aim 3: To investigate genetic risk factors associated with minimally verbal ASD, including both common and rare variants (Project 4). We plan to leverage the children enrolled in all the projects to explore the relationship between the quantitative load for common polygenic risk for ASD and language, motor, and neural phenotypes as well as genetic predictors of response to treatment and more optimal developmental outcomes (all Projects). The projects are united and served by an Administrative Core (A) and a Clinical and Data Management Scientific Core (B) that will carry out comprehensive assessments using available and novel measures to capture the heterogeneous phenotypes of minimally verbal children with ASD. Together, the research conducted in our Center will significantly advance our understanding of the profound communication deficits at this neglected end of the autism spectrum, develop behavioral and neural biomarkers that predict different developmental pathways for language, and may highlight potential molecular targets for future novel therapeutic interventions.
项目总结/摘要 许多患有ASD的儿童即使在接受高质量的干预措施后仍保持最低限度的语言能力。 最近的研究强调了这一群体的异质性,证实没有单一的机制可以 解释他们严重沟通障碍的根本原因。同时,创新针对性 行为干预可以在一定程度上改善言语和社会沟通, 言语的孩子该中心位于波士顿大学和加州洛杉矶大学, 洛杉矶,是建立在我们早期的工作解决一个中心主题: ASD儿童在早期上学期间获得语言,我们如何才能 推动这种进步?我们从多学科的角度来处理这些问题, 从沟通障碍、言语和运动科学中提取的工具、方法和途径, 发展神经科学、遗传学和干预研究。四个相互关联的项目解决了 以下目标。目的1:识别深层口语的运动和神经机制 语言障碍是自闭症儿童的最低语言障碍。在同一组的两个项目中 我们计划使用语言能力最低的儿童的语言能力状态来描述他们的口腔和一般运动功能。 最先进的技术和电生理学来探测神经功能(项目1,2)。目标2:推进 我们对如何优化语言能力最低的儿童的语言效果的理解, 自闭症我们通过进行一项行为干预的随机对照试验来解决这个问题, 社会沟通和orphantic目标(项目3),并通过跟踪目标1中研究的儿童两个 多年来探索运动和神经功能的变化如何预测不同的语言途径 (项目1、2)。目的3:研究与最小语言ASD相关的遗传风险因素, 包括常见和罕见的变体(项目4)。我们计划利用参加所有 项目探索ASD常见多基因风险的定量负荷与 语言、运动和神经表型以及治疗反应的遗传预测因子等 最佳发展成果(所有项目)。这些项目是统一的,并由一个行政核心服务 (A)以及临床和数据管理科学核心(B),将进行全面评估 使用现有的和新的措施,以捕捉异质性表型的最低语言儿童 关于ASD总之,在我们中心进行的研究将大大促进我们对 在自闭症谱系中被忽视的一端,严重的沟通缺陷, 神经生物标志物预测语言的不同发育途径,并可能突出潜在的 未来新型治疗干预的分子靶点。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

CONNIE L. KASARI其他文献

CONNIE L. KASARI的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('CONNIE L. KASARI', 18)}}的其他基金

PETAL: Promoting Early Intervention Timing and Attention to Language
PETAL:促进早期干预时机和对语言的关注
  • 批准号:
    10568487
  • 财政年份:
    2023
  • 资助金额:
    $ 32.05万
  • 项目类别:
Personalized, Responsive Intervention Sequences for Minimally Verbal Children with Autism (PRISM)
针对语言能力极低的自闭症儿童的个性化、响应式干预序列 (PRISM)
  • 批准号:
    9925806
  • 财政年份:
    2019
  • 资助金额:
    $ 32.05万
  • 项目类别:
Predicting and Optimizing Language Outcomes in Minimally Verbal Children with Autism Spectrum Disorder
预测和优化患有自闭症谱系障碍的最低限度语言儿童的语言结果
  • 批准号:
    10470952
  • 财政年份:
    2019
  • 资助金额:
    $ 32.05万
  • 项目类别:
ConProject-001
ConProject-001
  • 批准号:
    10470957
  • 财政年份:
    2019
  • 资助金额:
    $ 32.05万
  • 项目类别:
BLOOM: Boosting Language Outcomes of Minimally Verbal Children with ASD
BLOOM:提高自闭症谱系障碍儿童的语言能力
  • 批准号:
    10689723
  • 财政年份:
    2019
  • 资助金额:
    $ 32.05万
  • 项目类别:
BLOOM: Boosting Language Outcomes of Minimally Verbal Children with ASD
BLOOM:提高自闭症谱系障碍儿童的语言能力
  • 批准号:
    10470955
  • 财政年份:
    2019
  • 资助金额:
    $ 32.05万
  • 项目类别:
BLOOM: Boosting Language Outcomes of Minimally Verbal Children with ASD
BLOOM:提高自闭症谱系障碍儿童的语言能力
  • 批准号:
    10001018
  • 财政年份:
    2019
  • 资助金额:
    $ 32.05万
  • 项目类别:
ConProject-001
ConProject-001
  • 批准号:
    10001020
  • 财政年份:
    2019
  • 资助金额:
    $ 32.05万
  • 项目类别:
Community-based Adaptive autism Intervention for Toddlers
基于社区的幼儿适应性自闭症干预
  • 批准号:
    9923036
  • 财政年份:
    2019
  • 资助金额:
    $ 32.05万
  • 项目类别:
Predicting and Optimizing Language Outcomes in Minimally Verbal Children with Autism Spectrum Disorder
预测和优化患有自闭症谱系障碍的最低限度语言儿童的语言结果
  • 批准号:
    10689688
  • 财政年份:
    2019
  • 资助金额:
    $ 32.05万
  • 项目类别:

相似海外基金

Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
  • 批准号:
    MR/S03398X/2
  • 财政年份:
    2024
  • 资助金额:
    $ 32.05万
  • 项目类别:
    Fellowship
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
  • 批准号:
    2338423
  • 财政年份:
    2024
  • 资助金额:
    $ 32.05万
  • 项目类别:
    Continuing Grant
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
  • 批准号:
    EP/Y001486/1
  • 财政年份:
    2024
  • 资助金额:
    $ 32.05万
  • 项目类别:
    Research Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
  • 批准号:
    MR/X03657X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 32.05万
  • 项目类别:
    Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
  • 批准号:
    2348066
  • 财政年份:
    2024
  • 资助金额:
    $ 32.05万
  • 项目类别:
    Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
  • 批准号:
    AH/Z505481/1
  • 财政年份:
    2024
  • 资助金额:
    $ 32.05万
  • 项目类别:
    Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 32.05万
  • 项目类别:
    EU-Funded
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
  • 批准号:
    2341402
  • 财政年份:
    2024
  • 资助金额:
    $ 32.05万
  • 项目类别:
    Standard Grant
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 32.05万
  • 项目类别:
    EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
  • 批准号:
    AH/Z505341/1
  • 财政年份:
    2024
  • 资助金额:
    $ 32.05万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了