Biological Mechanisms of Perinatal Anxiety

围产期焦虑的生物学机制

• 批准号: 9925253
• 负责人: Lauren M Osborne
• 金额: $ 19.65万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-16 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9925253
• 关键词: Address; Affective Symptoms; Allopregnanolone; Anti-Anxiety Agents; Anxiety; Arousal; Attention deficit hyperactivity disorder; Autoimmune Process; Behavior; Biological; Biological Markers; Biometry; Blood specimen; Cells; Chemicals; Child; Cognitive deficits; Data; Data Analyses; Diagnostic; Disease; Educational workshop; Endocrine; Endocrine system; Epidemiology; Fingerprint; Fright; Future; Genetic Transcription; Gestational Diabetes; Goals; Health; Hormonal; Immune; Immune system; Immunity; Immunologic Factors; Immunologic Markers; Immunologics; Immunology; Individual; Individual Differences; Infection; Inflammatory; Knowledge; Laboratories; Learning; Leukocytes; Maternal and Child Health; Measurement; Measures; Mental Depression; Mental Health; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Methylation; Mission; Molecular Weight; Mothers; Nature; Neurobiology; Neuroendocrinology; Obsession; Organism; Patient Self-Report; Pattern; Perinatal; Peripheral; Pharmaceutical Preparations; Physiological; Physiology; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Postpartum Depression; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnant Women; Premature Birth; Progesterone; Proteins; Psychiatry; Psychoneuroimmunology; Psychopathology; Public Health; Reaction Time; Research; Research Domain Criteria; Risk; Risk Marker; Scientist; Solid; Stimulus; Suicide; Symptoms; Techniques; Th2 Cells; Time; Training; United States National Institutes of Health; Woman; adaptive immunity; anxiety states; anxiety symptoms; anxious; attentional bias; base; career; child bearing; cohort; conduct problem; cytokine; disability; experience; improved; maternal anxiety; meetings; monocyte; novel; perinatal period; prenatal; programs; prospective; reproductive; research study; response; skills; stressor; symposium; tool

PROJECT SUMMARY/ABSTRACT This is an application for a Mentored Patient-Oriented Research Career Development Award. The goal of the proposed project is to provide me with the advanced training necessary to establish an independent program of research in perinatal psychiatric disorders, and specifically in the contributions of immunological and endocrinological factors to perinatal psychopathology. To facilitate this long-term career goal, I will examine biological correlates of anxiety across pregnancy and the postpartum. I propose a comprehensive training plan, combining formal coursework in immunology and biostatistics with individual mentor meetings, applied training experiences, and participation in conferences, seminars, and workshops. Specific short-term training goals include: 1) Develop expertise in the psychoneuroimmunology of pregnancy and the postpartum 2) Gain a fuller understanding of reproductive hormonal physiology 3) Improve my understanding of biostatistics and epidemiology and develop a solid understanding of longitudinal data analysis 4) Refine my skill in measuring perinatal anxiety by learning how to administer laboratory stressors to pregnant women and measure the resultant autonomic reactivity and 5) Become adroit at integrating information about perinatal anxiety across numerous RDoC units of analysis, including cells, physiology, behaviors, self-reports, and paradigms. The training plan will be executed in conjunction with a proposed set of research studies based on preliminary data that I have collected and/or analyzed. These data demonstrate a relationship between inflammatory cytokines and TRAIT anxiety in pregnancy; between pro-inflammatory cytokines and STATE anxiety across the perinatal period; between allopregnanolone and obsessive symptoms in pregnancy; and between allopregnanolone in pregnancy and subsequent postpartum affective symptoms. The proposed research will build upon these preliminary findings by prospectively following a cohort of anxious pregnant women and healthy matched controls; by analyzing their blood samples for inflammatory cytokines, immune cells, and allopregnanolone; and by measuring maternal reactivity to a validated pregnancy-specific laboratory task that will measure attentional bias to threat and act as a stimulus for autonomic arousal.

项目总结/文摘