Biological Mechanisms of Perinatal Anxiety

围产期焦虑的生物学机制

• 批准号: 10210201
• 负责人: Lauren M Osborne
• 金额: $ 19.59万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-16 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10210201
• 关键词: Address; Affective Symptoms; Allopregnanolone; Anti-Anxiety Agents; Anxiety; Arousal; Attention deficit hyperactivity disorder; Autoimmune Diseases; Behavior; Biological; Biological Markers; Biometry; Blood specimen; Cells; Chemicals; Child; Cognitive deficits; Data; Data Analyses; Diagnostic; Disease; Educational workshop; Endocrine; Endocrine system; Epidemiology; Fingerprint; Fright; Future; Genetic Transcription; Gestational Diabetes; Goals; Health; Hormonal; Immune; Immune system; Immunity; Immunologic Factors; Immunologic Markers; Immunologics; Immunology; Individual; Individual Differences; Infection; Inflammatory; Knowledge; Laboratories; Learning; Leukocytes; Maternal and Child Health; Measurement; Measures; Mental Depression; Mental Health; Mental disorders; Mentored Patient-Oriented Research Career Development Award; Mentors; Methods; Methylation; Mission; Molecular Weight; Mothers; Nature; Neurobiology; Neuroendocrinology; Obsession; Organism; Patient Self-Report; Pattern; Perinatal; Peripheral; Pharmaceutical Preparations; Physiological; Physiology; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Postpartum Depression; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnant Women; Premature Birth; Progesterone; Proteins; Psychiatry; Psychoneuroimmunology; Psychopathology; Public Health; Reaction Time; Research; Research Domain Criteria; Risk; Risk Marker; Scientist; Solid; Stimulus; Suicide; Symptoms; Techniques; Th2 Cells; Time; Training; United States National Institutes of Health; Woman; adaptive immunity; anxiety states; anxiety symptoms; anxious; attentional bias; base; career; child bearing; cohort; conduct problem; cytokine; disability; experience; improved; maternal anxiety; meetings; monocyte; novel; perinatal period; prenatal; programs; prospective; reproductive; research study; response; skills; stressor; symposium; tool

PROJECT SUMMARY/ABSTRACT This is an application for a Mentored Patient-Oriented Research Career Development Award. The goal of the proposed project is to provide me with the advanced training necessary to establish an independent program of research in perinatal psychiatric disorders, and specifically in the contributions of immunological and endocrinological factors to perinatal psychopathology. To facilitate this long-term career goal, I will examine biological correlates of anxiety across pregnancy and the postpartum. I propose a comprehensive training plan, combining formal coursework in immunology and biostatistics with individual mentor meetings, applied training experiences, and participation in conferences, seminars, and workshops. Specific short-term training goals include: 1) Develop expertise in the psychoneuroimmunology of pregnancy and the postpartum 2) Gain a fuller understanding of reproductive hormonal physiology 3) Improve my understanding of biostatistics and epidemiology and develop a solid understanding of longitudinal data analysis 4) Refine my skill in measuring perinatal anxiety by learning how to administer laboratory stressors to pregnant women and measure the resultant autonomic reactivity and 5) Become adroit at integrating information about perinatal anxiety across numerous RDoC units of analysis, including cells, physiology, behaviors, self-reports, and paradigms. The training plan will be executed in conjunction with a proposed set of research studies based on preliminary data that I have collected and/or analyzed. These data demonstrate a relationship between inflammatory cytokines and TRAIT anxiety in pregnancy; between pro-inflammatory cytokines and STATE anxiety across the perinatal period; between allopregnanolone and obsessive symptoms in pregnancy; and between allopregnanolone in pregnancy and subsequent postpartum affective symptoms. The proposed research will build upon these preliminary findings by prospectively following a cohort of anxious pregnant women and healthy matched controls; by analyzing their blood samples for inflammatory cytokines, immune cells, and allopregnanolone; and by measuring maternal reactivity to a validated pregnancy-specific laboratory task that will measure attentional bias to threat and act as a stimulus for autonomic arousal.

项目总结/摘要 这是一个指导病人为导向的研究职业发展奖的申请。该项目的目标是为我提供必要的高级培训，以建立一个独立的围产期精神疾病研究计划，特别是免疫和内分泌因素对围产期精神病理学的贡献。为了促进这个长期的职业目标，我将研究怀孕和产后焦虑的生物学相关性。我提出了一个全面的培训计划，结合正式的课程在免疫学和生物统计学与个别导师会议，应用培训经验，并参加会议，研讨会和讲习班。具体的短期培训目标包括：1）发展妊娠和产后心理神经免疫学的专业知识2）更全面地了解生殖激素生理学3）提高我对生物统计学和流行病学的理解，并对纵向数据分析有扎实的理解4）通过学习如何向孕妇施加实验室压力源并测量由此产生的自主反应来提高我测量围产期焦虑的技能;熟练地将围产期焦虑的信息整合到众多的RDoC分析单元中，包括细胞、生理学、行为、自我报告和范式。培训计划将与基于我收集和/或分析的初步数据的一组拟议研究一起执行。这些数据表明炎症细胞因子和TRAIT焦虑在怀孕期间之间的关系;促炎细胞因子和状态焦虑在围产期之间; alopregnanolone和强迫症状在怀孕期间之间; alopregnanolone在怀孕期间和随后的产后情感症状之间。拟议的研究将建立在这些初步发现的基础上，前瞻性地跟踪一组焦虑的孕妇和健康的匹配对照;通过分析他们的血液样本中的炎性细胞因子，免疫细胞和alopregnanolone;并通过测量母体对经验证的妊娠特异性实验室任务的反应，该任务将测量对威胁的注意力偏差并作为自主觉醒的刺激。

项目成果

Perinatal Obsessive-Compulsive Disorder: Epidemiology, Phenomenology, Etiology, and Treatment.

• DOI: 10.1007/s11920-022-01333-4
• 发表时间: 2022-04
• 期刊: CURRENT PSYCHIATRY REPORTS
• 影响因子: 6.7
• 作者: Hudepohl, Neha;MacLean, Joanna V.;Osborne, Lauren M.
• 通讯作者: Osborne, Lauren M.

The Crisis of Perinatal Mental Health in the Age of Covid-19.

Covid-19时代的围产期心理健康危机。

• DOI: 10.1007/s10995-020-03114-y
• 发表时间: 2021-03
• 期刊: Maternal and child health journal
• 影响因子: 2.3
• 作者: Osborne LM;Kimmel MC;Surkan PJ
• 通讯作者: Surkan PJ

Setting Common Standards for Reproductive Psychiatry Education: Effectiveness of the National Curriculum in Reproductive Psychiatry.

制定生殖精神病学教育共同标准：生殖精神病学国家课程的有效性。

• DOI: 10.1007/s40596-022-01663-8
• 发表时间: 2023
• 期刊: Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry
• 作者: Erdly,Courtney;Etyemez,Semra;Standeven,LindsayR;Nagle-Yang,Sarah;Osborne,LaurenM
• 通讯作者: Osborne,LaurenM

Metabolites of progesterone in pregnancy: Associations with perinatal anxiety.

怀孕期间黄体酮的代谢：与围产期焦虑的关联。

• DOI: 10.1016/j.psyneuen.2023.106327
• 发表时间: 2023
• 期刊: Psychoneuroendocrinology
• 影响因子: 3.7
• 作者: Etyemez,Semra;Miller,KristenN;Voegtline,KristinM;Özdemir,İpek;Standeven,LindsayR;Santovito,LucaSpiro;Pinna,Graziano;Payne,JenniferL;Osborne,LaurenM
• 通讯作者: Osborne,LaurenM

Eighteen-year-old man with autism, obsessive compulsive disorder and a SHANK2 variant presents with severe anorexia that responds to high-dose fluoxetine.

一名患有自闭症、强迫症和 SHANK2 变异的 18 岁男子出现严重厌食症，对大剂量氟西汀有反应。

• DOI: 10.1136/bcr-2018-225119
• 发表时间: 2018
• 期刊: BMJ case reports
• 影响因子: 0.9
• 作者: Lu,ZhenA;Mu,Weiyi;Osborne,LaurenM;Cordner,ZacharyA
• 通讯作者: Cordner,ZacharyA