The International Workshop on HIV Dynamics and Evolution

描述（由申请人提供）：一年一度的艾滋病毒动力学和进化国际研讨会聚集了来自各个研究领域的人们，探讨病毒动力学和进化如何为宿主-病原体相互作用以及艾滋病毒/艾滋病的出现、传播和遏制的机制提供见解。会议讨论了进化生物学中的新兴主题，以获得对支撑艾滋病毒/艾滋病的进化过程的理论理解和数学描述。会议的目标是强调该领域的最新发展，促进相关学科之间的对话和合作。召开这次会议的理由是，其他会议没有同样独特的重点或多学科内容。涵盖的主题包括逆转录病毒的进化史和多样化、新数学算法的进展和应用、病毒、宿主及其免疫反应之间相互作用的建模、感染动力学和流行行为。项目委员会的管理和监督确保了会议的高质量、新颖性和一致性。选定的演讲者确保广泛的地域代表性，良好的性别平衡，以及正在科学界发展其声誉并将为该领域注入活力的年轻研究人员的出席。会议加强了与会者之间的互动，为理论家和实验家创造了一个活跃的网络，以解决基本问题并加速艾滋病毒/艾滋病研究的发现。由于它的独特性，这次会议可以完成其他会议在产生知识、创造新的共识、增加合作机会和开辟进化生物学研究的新领域方面无法完成的任务。多学科场地允许学员和年轻的研究人员刚刚开始他们的职业道路，与国际公认的专家密切互动，指导。年会的范围和意义不断扩大，从根本上改变了艾滋病毒/艾滋病研究的格局。17年的会议历史表明，这一议题具有可行性、专业性以及合作的良好记录。为了传播信息和探索这一科学研究领域，会议的具体目标是：促进与艾滋病毒动态和演变有关的最新成果的交流；为这些领域的不同假设提供辩论和讨论的论坛；并将新的数学方法整合到发病机制研究、药物治疗和疫苗设计中。

DESCRIPTION (provided by applicant): The annual International Workshop on HIV Dynamics and Evolution gathers people from a wide variety of research areas to explore how viral dynamics and evolution provide insight into the mechanisms that underlie host-pathogen interactions and the emergence, spread, and containment of HIV/AIDS. The meetings address emerging themes in evolutionary biology in order to gain a theoretical understanding and mathematical description of the evolutionary processes that underpin HIV/AIDS. The meeting objectives are to highlight state-of-the-art developments in the field and promote dialog and collaboration across the related disciplines. The rationale for the meeting is that other conferences do not have the same unique focus or multidisciplinary content. Topics covered include the evolutionary history and diversification of retroviruses, advances in and the application of new mathematical algorithms, modeling of the interaction between the virus, the host and its immune response, and infection dynamics and epidemic behavior. Program Committee governance and oversight assures the quality, novelty and consistency of a highly interactive meeting. The selected speakers ensure wide geographical representation, good gender balance, and attendance of young investigators who are developing their reputations in the scientific community and who will invigorate the field. The meeting has enhanced interactions among the attendees to create an active network for theoreticians and experimentalists in order to address fundamental issues and accelerate discovery in HIV/AIDS research. Because of its uniqueness, the meeting can accomplish what other meetings cannot with regard to generating knowledge, creating new consensus, increasing opportunity for collaboration, and opening new areas of evolutionary biology research. The multidisciplinary venue allows trainees and young investigators just starting their career paths to interact closely with internationally recognized experts for mentoring. The annual meeting has grown in scope and significance, fundamentally reshaping the HIV/AIDS research landscape. The 17-year history of the meeting shows feasibility, expertise in the topic, and a track record of working together. To disseminate information and explore this area of scientific research, the specific aims of the meetings are to: facilitate communication of the most recent results relating to HIV dynamics and evolution; provide a forum for debate and discussion of alternative hypotheses in these areas; and integrate new mathematical approaches into pathogenesis research, drug therapy, and vaccine design. PUBLIC HEALTH RELEVANCE: Viral genetic variation, driven by host genetics and immunity, is the basis of HIV infection dynamics and epidemic behavior, and a central agenda for HIV/AIDS research. It is increasingly evident that the nature and extent of HIV genetic variation, the biological and evolutionary processes that have produced the observed patterns, and the human genes and their relevant genetic variants, are central to the evolution of virulence and drug resistance, and to vaccine design. The International Workshop on HIV Dynamics and Evolution will bring together leaders in the field to address key aspects of the mechanisms that underlie host-pathogen interactions and contribute to the emergence, spread, and containment of HIV/AIDS.