Coordination of Eye and Head Movements in Central Field Loss
中心场丢失时眼睛和头部运动的协调
基本信息
- 批准号:9934852
- 负责人:
- 金额:$ 3.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-08-01 至 2020-09-29
- 项目状态:已结题
- 来源:
- 关键词:AccidentsAddressAffectAgeAge related macular degenerationAgreementAnimalsBehaviorBlindnessCalibrationCategoriesCentral ScotomasDangerousnessDarknessDataDependenceDiagnostic ProcedureDizzinessElderlyEnvironmentEvolutionEyeEye MovementsFunctional disorderHeadHead MovementsImageImpairmentIncidenceIndividualInjuryLeadLife StyleMechanicsMentorsMotionMotion PerceptionMovementOcular orbitOphthalmologyOutcomeParticipantPathway interactionsPatient-Focused OutcomesPatientsPerformancePhasePlanet EarthPlayPopulationPositioning AttributePublicationsReflex actionResearchRetinaRetinalRotationShort Interspersed Nucleotide ElementsSmooth PursuitSourceSpottingsStimulusSumSystemTestingTherapeuticTrainingTranslatingTranslationsVisionVisualVisual AcuityVisual FieldsVisual impairmentVisual system structureVolitionWorkcentral visual fielddisabilityfallsfovea centralisgazeimprovedinterestmeetingsoculomotoroculomotor behaviorpatient populationresponsesample fixationsenescencevestibulo-ocular reflexvisual feedbackvisual informationvisual stimulusvisual-vestibular
项目摘要
Age-related macular degeneration is the most common cause of vision loss in the central visual field, making
central field loss (CFL) a major problem in the world today. Two-thirds of patients with CFL complain of
vestibular problems, such as dizziness and instability, leading to a high incidence of potentially fatal accidents
and falls. The problem is exacerbated by the patient population's advanced age, due to a documented decline
in vestibular function in senescence. Vestibular deficits in CFL patients are likely due to miscalibrated or non-
optimal stabilizing eye movements - many essential oculomotor behaviors are highly reliant on retinal input.
Individuals with compromised vestibular responses have difficulties with visual field stability, navigation, and
self- and external motion perception. These limitations are particularly true for CFL patients, whose visual
acuity is already compromised and for whom the vestibular system may be the predominant source of motion
information. Despite the importance of visual/vestibular interaction, these behaviors have not been
comprehensively studied in CFL. This proposal seeks to address this gap. Evidence from the K99 stage
indicates that individuals with CFL rely more on head movements for smooth pursuit than controls.
Furthermore, these data support previous findings that head movement may improve smooth pursuit
performance. Aim 1 of the R00 stage will extend these findings by directly addressing how vestibuloocular
reflex (VOR) cancellation might play into the head-free smooth pursuit response. Further, this aim examines
the effect of CFL on the angular VOR itself. The reflex has little foveal dependence. However, foveal vision is
known to contribute to both VOR calibration and to its suppression when the head movement follows target
motion. A deficit in any aspect of angular VOR will have consequences on the visual instability and vestibular
discomfort of the affected individuals. Understanding these problems would inform necessary treatments in this
population. Aim 2 examines the effects of CFL on translational VOR, a behavior that is fovea-dependent and
essential when body movement is present. Determining the degree of its impairment and exact influences of
CFL is key to understanding vestibular dysfunction due to CFL. VOR responses will be studied during passive
and active motion. Previous research suggests fundamental differences in the processing of these two types of
behavior, which indicates that they might be affected differently by central vision loss. If present, this dichotomy
could have implications for how patients are advised and trained to interact with their environment while
maintaining an active and productive lifestyle.
!
!
老年性黄斑变性是导致中央视野视力丧失的最常见原因
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Natela M. Shanidze其他文献
Natela M. Shanidze的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Natela M. Shanidze', 18)}}的其他基金
Effects of Noise Exposure Across the Lifespan on Balance and Stability in Older Adults
一生中噪声暴露对老年人平衡和稳定性的影响
- 批准号:
10276071 - 财政年份:2021
- 资助金额:
$ 3.03万 - 项目类别:
Effects of Noise Exposure Across the Lifespan on Balance and Stability in Older Adults
一生中噪声暴露对老年人平衡和稳定性的影响
- 批准号:
10491815 - 财政年份:2021
- 资助金额:
$ 3.03万 - 项目类别:
Effects of Noise Exposure Across the Lifespan on Balance and Stability in Older Adults
一生中噪声暴露对老年人平衡和稳定性的影响
- 批准号:
10670349 - 财政年份:2021
- 资助金额:
$ 3.03万 - 项目类别:
Effects of Noise Exposure Across the Lifespan on Balance and Stability in Older Adults
一生中噪声暴露对老年人平衡和稳定性的影响
- 批准号:
10833752 - 财政年份:2021
- 资助金额:
$ 3.03万 - 项目类别:
Coordination of Eye and Head Movements in Central Field Loss
中心场丢失时眼睛和头部运动的协调
- 批准号:
9790966 - 财政年份:2016
- 资助金额:
$ 3.03万 - 项目类别:
Coordination of Eye and Head Movements in Central Field Loss
中心场丢失时眼睛和头部运动的协调
- 批准号:
9360137 - 财政年份:2016
- 资助金额:
$ 3.03万 - 项目类别:
相似海外基金
Rational design of rapidly translatable, highly antigenic and novel recombinant immunogens to address deficiencies of current snakebite treatments
合理设计可快速翻译、高抗原性和新型重组免疫原,以解决当前蛇咬伤治疗的缺陷
- 批准号:
MR/S03398X/2 - 财政年份:2024
- 资助金额:
$ 3.03万 - 项目类别:
Fellowship
Re-thinking drug nanocrystals as highly loaded vectors to address key unmet therapeutic challenges
重新思考药物纳米晶体作为高负载载体以解决关键的未满足的治疗挑战
- 批准号:
EP/Y001486/1 - 财政年份:2024
- 资助金额:
$ 3.03万 - 项目类别:
Research Grant
CAREER: FEAST (Food Ecosystems And circularity for Sustainable Transformation) framework to address Hidden Hunger
职业:FEAST(食品生态系统和可持续转型循环)框架解决隐性饥饿
- 批准号:
2338423 - 财政年份:2024
- 资助金额:
$ 3.03万 - 项目类别:
Continuing Grant
Metrology to address ion suppression in multimodal mass spectrometry imaging with application in oncology
计量学解决多模态质谱成像中的离子抑制问题及其在肿瘤学中的应用
- 批准号:
MR/X03657X/1 - 财政年份:2024
- 资助金额:
$ 3.03万 - 项目类别:
Fellowship
CRII: SHF: A Novel Address Translation Architecture for Virtualized Clouds
CRII:SHF:一种用于虚拟化云的新型地址转换架构
- 批准号:
2348066 - 财政年份:2024
- 资助金额:
$ 3.03万 - 项目类别:
Standard Grant
BIORETS: Convergence Research Experiences for Teachers in Synthetic and Systems Biology to Address Challenges in Food, Health, Energy, and Environment
BIORETS:合成和系统生物学教师的融合研究经验,以应对食品、健康、能源和环境方面的挑战
- 批准号:
2341402 - 财政年份:2024
- 资助金额:
$ 3.03万 - 项目类别:
Standard Grant
The Abundance Project: Enhancing Cultural & Green Inclusion in Social Prescribing in Southwest London to Address Ethnic Inequalities in Mental Health
丰富项目:增强文化
- 批准号:
AH/Z505481/1 - 财政年份:2024
- 资助金额:
$ 3.03万 - 项目类别:
Research Grant
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10107647 - 财政年份:2024
- 资助金额:
$ 3.03万 - 项目类别:
EU-Funded
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
- 批准号:
10106221 - 财政年份:2024
- 资助金额:
$ 3.03万 - 项目类别:
EU-Funded
Recite: Building Research by Communities to Address Inequities through Expression
背诵:社区开展研究,通过表达解决不平等问题
- 批准号:
AH/Z505341/1 - 财政年份:2024
- 资助金额:
$ 3.03万 - 项目类别:
Research Grant