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Effects of Noise Exposure Across the Lifespan on Balance and Stability in Older Adults

一生中噪声暴露对老年人平衡和稳定性的影响

基本信息

批准号：
10833752
负责人：
Natela M. Shanidze
金额：
$ 3.59万
依托单位：
VETERANS EDUCATION AND RESEARCH ASSOCIATION OF MICHIGAN
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-30 至 2026-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10833752
关键词：
Acceleration Accidents Acoustics Address Affect Age Aging Anatomy Animal Experimentation Animal Model Animals Basic Science Cells Cervical Cessation of life Characteristics Clinical Cochlea Compensation Control Groups Detection Devices Diagnosis Disease Dose Elderly Electrophysiology (science)Environment Epithelium Equilibrium Exhibits Exposure to FDA approved Force of Gravity Frequencies Functional disorder Genetic Goals Head Head Movements Hearing Human Impairment Individual Injury Investigation Judgment Labyrinth Life Link Longevity Maintenance Measurement Measures Methods Modeling Morphology Motion Motor Musculoskeletal Equilibrium Neurons Noise Noise-Induced Hearing Loss Organ Outcome Participant Performance Physical shape Physiological Play Population Posture Predisposition Prevention Proprioception Rattus Recommendation Recording of previous events Reflex action Rehabilitation therapy Risk Risk Factors Role Rotation Secondary to Semicircular canal structure Sensory Source Spinal Cord Structure Symptoms System Testing Time Training Variant Vestibular Nerve Vestibular loss Vision Walking age group age related aging population body position clinical application cohort comparison control cost disability equipment acquisition experimental study fall risk falls functional improvement human old age (65+)human subject improved insight motor impairment neglect noise exposure otoconia parent grant posture instability pressure response secondary analysis senescence sound treatment strategy vestibulo-ocular reflex

项目摘要

Abstract Loss of stability and falls is a major risk factor for injury and death in older adults. Previously overlooked, lifetime noise exposure has been shown to cause damage to the vestibular periphery; although, animal models and human studies that can provide a mechanistic basis connecting noise-induced vestibular dysfunction and age-related fall risk are limited. The vestibular system plays a critical role in detection of head movements and orientation with respect to gravity and is essential for normal vision and postural control. Due to their anatomical proximity to the cochlea, the otolith organs are exposed to sound pressure and are at risk for noise overstimulation, which may contribute to vestibular dysfunction. Recent studies have linked noise overstimulation to decreased vestibular nerve activity and loss of a specialized class of irregularly firing vestibular afferents which exhibit enhanced sensitivity to acceleration. It is likely that these afferents play an important role initiating postural compensation for abrupt changes in head or body position due to their physiological characteristics and their projection to secondary vestibular neurons that project to the spinal cord. Therefore, the effects of noise may accelerate disability associated with natural aging. The goal of this supplement is to purchase equipment to measure vestibular evoked myogenic potentials (VEMP) in human participants, and thus assess changes in otolith function associated with noise exposure. The inclusion of VEMP reflects Reviewer recommendation to use vestibular-evoked myogenic potentials to directly assess how noise exposure might affect otolith function in humans and compare to outcomes in the rat. The VEMP experiments will be performed in lieu of the dynamic tilt detection experiments proposed in the parent grant. VEMP testing can be done in the same, or shorter amount of time to assess otolith function under dynamic stimulation conditions. This supplement will allow us to incorporate a well-characterized physiological assessment in human subjects to evaluate the underlying mechanisms in increased falls and fall risk due to a history of noise exposure in older adults. The susceptibility of these individuals to potentially fatal falls underscores the need for a systematic approach, that can eventually result in improved training and rehabilitation methods to be used with this population.

摘要失稳和福尔斯是老年人受伤和死亡的主要危险因素。以前被忽视的，已经证明，终生暴露于噪声会对前庭周围造成损害;尽管动物模型和人类研究，可以提供一个机械基础连接噪声引起的前庭功能障碍，与年龄相关的跌倒风险有限。前庭系统在头部运动的检测中起着关键作用，相对于重力定向，并且对于正常视觉和姿势控制是必不可少的。由于其由于耳石器官在解剖学上接近耳蜗，因此耳石器官暴露在声压下，并有噪声的风险过度刺激，这可能导致前庭功能障碍。最近的研究表明噪音过度刺激导致前庭神经活动减少和一类特殊的不规则放电丧失前庭传入神经对加速度表现出增强的敏感性。很可能这些传入神经起着重要的作用，启动姿势补偿头部或身体位置的突然变化，由于他们的生理特性及其对投射到脊髓的次级前庭神经元的投射。因此，噪音的影响可能会加速与自然衰老相关的残疾。这个目标补充是购买设备来测量人类前庭诱发肌源性电位（VEMP 参与者，从而评估与噪声暴露相关的耳石功能的变化。列入 VEMP反映了评审员建议使用前庭诱发肌源性电位直接评估噪声暴露可能会影响人类的耳石功能，并与大鼠的结果进行比较。VEMP 将进行实验，以代替母基金建议的动态倾斜检测实验。 VEMP测试可以在相同或更短的时间内完成，以评估动态下的耳石功能刺激条件这种补充将使我们能够将一个良好的特征化的生理在人类受试者中进行评估，以评价由于以下原因导致的福尔斯和跌倒风险增加的潜在机制：老年人的噪音暴露史。这些个体对潜在致命福尔斯跌落的易感性强调需要采取系统的办法，最终改进培训，对这一人群使用的康复方法。