Michigan MoTrPAC Chemical Analysis Site (MiCAS)

密歇根 MoTrPAC 化学分析站点 (MiCAS)

• 批准号: 9930706
• 负责人: CHARLES F BURANT
• 金额: $ 101.32万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-18 至 2019-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9930706
• 关键词: Acute; Adipose tissue; Aerobic; Age; Androgens; Animals; Blood specimen; Chemicals; Estrogens; Exercise; Funding; Health; Human; Maps; Michigan; Molecular; Molecular Analysis; Molecular Profiling; Muscle; Participant; Persons; Physical activity; Race; Resistance; Sampling; Site; Tissues; Transducers; Universities; Woman; Workload; exercise training; human study; men; metabolomics; response; sex

ABSTRACT: The Molecular Transducers of Physical Activity (MoTrPAC) project is defining the molecular profiles of acute exercise and exercise training and the variability in response to exercise type (resistance v. aerobic) and influences of sex, age and race on the response. The molecular responses will be integrated and mapped The University of Michigan’s Chemical Analysis Site has been assigned a work-load of ‘untargeted’ metabolomic analysis of tissues from both animal and humans participating in the study and androgens and estrogens from the baseline samples from men and women. The supplemental funds request is to support the assigned workload of the human study. Approximately 2-fold the number of samples of blood, muscle and adipose tissue originally estimated in the RFA will be collected for molecular analysis from the human participants.

摘要： 体力活动的分子传感器(MoTrPAC)项目正在定义分子 急性运动和运动训练的概况及运动类型的变异性 (抵抗力与好氧性)以及性别、年龄和种族对反应的影响。分子 将对密歇根大学的化学分析站点进行整合并绘制地图 已经被分配了一项对这两种动物组织的代谢组学分析的工作量 以及参与研究的人类和基线样本中的雄激素和雌激素 从男人和女人那里。 申请补充资金是为了支持人体研究分配的工作量。 血液、肌肉和脂肪组织的样本数量大约是原来的两倍 在RFA中的估计将从人类参与者那里收集用于分子分析。