Evaluating Impact of Diet and Fresh Food Access on Aggressive Prostate Cancer using Multi-Level Modeling

行政副刊摘要 此申请是根据NOT-CA-19-029提交的。此应用程序请求 补充资金，以利用现有资源，包括生鲜食品店、乡村和 社会经济状况(SES)以说明体质和社会环境因素在前列腺癌中的作用 进取性(支持父母赠款的目标1)。我们将检查以前已确定的病因 与获取新鲜食物的地理空间相关的因素(如叶酸/叶酸摄入量、DHFR多态) 采用多水平Logistic回归模型。我们假设个人拥有更大的地理空间访问权限 新鲜食物会有更高的叶酸摄入量，相应地降低了高攻击性的可能性 前列腺癌，由DHFR基因多态修饰。我们提出以下补充目标：1) 研究生鲜食品销售点的地理空间可达性与叶酸饮食摄入量之间的关系 在环境影响评估和环境影响评估之间，以及2)评估新鲜食品店地理空间可达性的多级关联， 社会经济地位和前列腺癌侵袭性。拟议的补编将 扩大和加强家长补助金的目标1，不仅调查个人层面的饮食因素，而且还 社会和建筑环境在前列腺癌侵袭性中的作用并提供更多的洞察力 前列腺癌病因的复杂性。圆满完成拟议的补充目标将 帮助在多个级别确定可修改的风险因素，加强父母赠款的影响，并 为更广泛的科学界提供宝贵的资源。

ADMINISTRATIVE SUPPLEMENT ABSTRACT This application is being submitted in response to NOT-CA-19-029. This application requests supplemental funding to leverage existing resources including location data for fresh food outlets, rurality, and socioeconomic status (SES) to address the role of built and social environmental factors on prostate cancer aggressiveness (in support of Aim 1 of the parent grant). We will examine previously identified etiological factors (e.g. folate/folic acid intake, DHFR polymorphism) in connection with geospatial access to fresh food using a multi-level logistic regression model. We hypothesize individuals with greater geospatial access to fresh foods will have higher dietary intake of folate and a corresponding reduced likelihood of high-aggressive prostate cancer, modified by the DHFR polymorphism. We propose the following supplemental aims: 1) examine the association between geospatial accessibility to fresh food outlets and dietary intake of folate among EAs and AAs, and 2) evaluate the multilevel association of geospatial accessibility to fresh food outlets, socioeconomic status, and prostate cancer aggressiveness in EAs and AAs. The proposed supplement will expand and enhance Aim 1 of the parent grant to investigate not only individual-level dietary factors, but also the role of the social and built environment on prostate cancer aggressiveness and provide greater insight into the complex nature of prostate cancer etiology. Successful completion of the proposed supplemental aims will help identify modifiable risk factors at multiple scales, strengthening the impact of the parent grant and providing a valuable resource for the broader scientific community.