Evaluating Impact of Diet and Fresh Food Access on Aggressive Prostate Cancer using Multi-Level Modeling

行政管理摘要 本申请是根据NOT-CA-19-029提交的。本申请要求 补充资金，以利用现有资源，包括新鲜食品店的位置数据，农村， 社会经济地位（SES），以解决前列腺癌的建成和社会环境因素的作用 积极进取（支持母公司补助金的目标1）。我们将检查先前确定的病因 与获取新鲜食物的地理空间相关的因素（如叶酸/叶酸摄入量、DHFR多态性） 使用多层次逻辑回归模型。我们假设个人有更大的地理空间访问， 新鲜的食物会有更高的叶酸摄入量，相应地减少高侵袭性的可能性。 前列腺癌，由DHFR多态性修饰。我们提出以下补充目标：1） 研究新鲜食品店的地理可达性与叶酸摄入量之间的关系 在EA和AA之间，以及2）评估新鲜食品店的地理空间可达性的多层次关联， 社会经济地位和前列腺癌的侵袭性。拟议的补编将 扩大和加强父母补助金的目标1，不仅调查个人层面的饮食因素， 社会和建筑环境对前列腺癌侵袭性的作用，并提供更深入的了解 前列腺癌病因的复杂性。成功完成拟议的补充目标将 帮助在多个尺度上确定可改变的风险因素，加强父母补助金的影响， 为更广泛的科学界提供了宝贵的资源。

ADMINISTRATIVE SUPPLEMENT ABSTRACT This application is being submitted in response to NOT-CA-19-029. This application requests supplemental funding to leverage existing resources including location data for fresh food outlets, rurality, and socioeconomic status (SES) to address the role of built and social environmental factors on prostate cancer aggressiveness (in support of Aim 1 of the parent grant). We will examine previously identified etiological factors (e.g. folate/folic acid intake, DHFR polymorphism) in connection with geospatial access to fresh food using a multi-level logistic regression model. We hypothesize individuals with greater geospatial access to fresh foods will have higher dietary intake of folate and a corresponding reduced likelihood of high-aggressive prostate cancer, modified by the DHFR polymorphism. We propose the following supplemental aims: 1) examine the association between geospatial accessibility to fresh food outlets and dietary intake of folate among EAs and AAs, and 2) evaluate the multilevel association of geospatial accessibility to fresh food outlets, socioeconomic status, and prostate cancer aggressiveness in EAs and AAs. The proposed supplement will expand and enhance Aim 1 of the parent grant to investigate not only individual-level dietary factors, but also the role of the social and built environment on prostate cancer aggressiveness and provide greater insight into the complex nature of prostate cancer etiology. Successful completion of the proposed supplemental aims will help identify modifiable risk factors at multiple scales, strengthening the impact of the parent grant and providing a valuable resource for the broader scientific community.