SLEEP QUALITY AND HUMAN AMLYOID-BETA KINETICS

睡眠质量和人类淀粉样蛋白-β 动力学

• 批准号: 9934836
• 负责人: Brendan Patrick Lucey
• 金额: $ 16.01万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9934836
• 关键词: Abeta synthesis; Administrative Supplement; Affect; Aging; Alzheimer' s Disease; Amyloid beta-Protein; Applications Grants; Cerebrospinal Fluid; Data; Development; Goals; Human; Individual; Kinetics; Neuraxis; Neurodegenerative Disorders; Neurology; Pathogenesis; Pharmacology; Physicians; Production; Proteins; Publishing; Research; Sampling; Scientist; Sleep; Sleep Deprivation; Sleep disturbances; Testing; Universities; Washington; Work; alpha synuclein; cost; hypocretin; improved; interest; novel; parent grant; prevent; professor; programs; receptor; sleep quality; tau Proteins; tau phosphorylation; tau-1; tenure track

Project Summary: Dr. Brendan Lucey, MD is a highly-motivated physician-scientist with a strong interest in sleep, aging, and neurodegenerative disorders such as Alzheimer’s disease. He is an Assistant Professor of Neurology (tenure track) at Washington University and is seeking support from this administrative supplement for research costs to explore novel changes in cerebrospinal fluid (CSF) tau, phosphorylated tau (p-tau), and α-synuclein concentrations with sleep-wake activity and pharmacologic sleep induction via orexin receptor antagonism from suvorexant. Dr. Lucey’s long-term goal is to develop an exciting research program investigating the interrelationships between sleep, aging, and Alzheimer’s disease. Understanding these relationships could drive the development of new treatments to prevent or delay Alzheimer’s disease. This administrative supplement request builds on recently published work and our unpublished preliminary data showing that sleep loss increases concentrations of tau and α-synuclein in cerebrospinal fluid (CSF) and affects the forms of phosphorylated tau (p-tau). Further, this supplement will leverage novel samples collected as part of the parent grant.

项目概要： 博士Brendan Lucey医学博士是一位积极进取的医生科学家，对睡眠、衰老和 神经退行性疾病，如阿尔茨海默病。他是神经病学助理教授（终身教职 轨道）在华盛顿大学，并正在寻求支持，从这一行政补充的研究费用 探索脑脊液（CSF）tau、磷酸化tau（p-tau）和α-突触核蛋白的新变化 浓度与睡眠-觉醒活动和通过食欲素受体拮抗作用的药理学睡眠诱导 来自苏沃雷生。Lucey博士的长期目标是开发一个令人兴奋的研究项目， 睡眠、衰老和阿尔茨海默病之间的相互关系。了解这些关系可以 推动新的治疗方法的发展，以预防或延迟阿尔茨海默病。这一行政 补充请求建立在最近发表的工作和我们未发表的初步数据的基础上，这些数据表明， 损失增加脑脊液（CSF）中tau和α-突触核蛋白的浓度，并影响 磷酸化tau（p-tau）。此外，该补充将利用收集的新样本作为 家长补助

项目成果

Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS.

Suvorexant 急剧降低人类中枢神经系统中的 Tau 磷酸化和 Aβ。

• DOI: 10.1002/ana.26641
• 发表时间: 2023
• 期刊: Annals of neurology
• 影响因子: 11.2
• 作者: Lucey,BrendanP;Liu,Haiyan;Toedebusch,CristinaD;Freund,David;Redrick,Tiara;Chahin,SamirL;Mawuenyega,KwasiG;Bollinger,JamesG;Ovod,Vitaliy;Barthélemy,NicolasR;Bateman,RandallJ
• 通讯作者: Bateman,RandallJ

Age differences in the association between sleep and Alzheimer's disease biomarkers in the EPAD cohort.

• DOI: 10.1002/dad2.12380
• 发表时间: 2022
• 期刊: Alzheimer's & dementia (Amsterdam, Netherlands)