Functional Proteomics of Aging

衰老的功能蛋白质组学

基本信息

  • 批准号:
    9927539
  • 负责人:
  • 金额:
    $ 44.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-05-01 至 2023-04-30
  • 项目状态:
    已结题

项目摘要

Abstract/Summary A group of investigators at the University of Minnesota seeks to renew “Functional Proteomics of Aging”, a Training Program that helps exceptional young scientists develop the intellectual and technical tools needed for productive careers as independent investigators and educators in aging research. The program has supported annually 4 predoctoral and 2 postdoctoral trainees. The Training Program is in its 10th year of funding and has trained 16 predoctoral and 9 postdoctoral trainees, who have successful careers. In addition to the research conducted in the mentor’s laboratory, trainees receive didactic (4 courses, 2 workshops) and experiential training in gerontology and proteomics (conferences, seminars, symposia, journal clubs, group meetings with Program faculty members, and a new visitorship program to Nathan Shock Centers). The experiential training is designed to maximize interaction among trainees and Training faculty from multiple labs and with scientists involved in aging research outside the U of MN. Faculty mentors draw trainees from six graduate programs at the University of Minnesota: Biochemistry, Molecular Biology and Biophysics (BMBB), Chemistry (Chem), Experimental and Clinical Pharmacology (ECP), Integrative Biology and Physiology (IBP) and Neuroscience (NSc), and Rehabilitation Sciences (RSc). The mentors’ research programs focus on the use proteomic and other advanced state-of-the-art technologies to reveal the molecular details behind the age- related loss in tissue function and/or age-related disease and are conceptually organized into four foci: loss of muscle function with age and disease, decline of the central nervous system with age and disease, the metabolism and signaling of aging and longevity, and development of technology for the advancement of aging research. Our research is supported by outstanding cores equipped with a variety of state-of-the-art mass spectrometers in the Center for Mass Spectrometry and Proteomics and bioinformatics platforms in the Minnesota Supercomputers Institute. Training faculty laboratories also contain specialized analytical equipment that is commonly shared between Program faculty. Together, the cadre of distinguished mentors, the extensive interdisciplinary collaborations among faculty and trainees of multiple departments, the technological resources, and the didactic and experiential training helps our trainees to shape successful careers.
抽象/总结

项目成果

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EDGAR A ARRIAGA其他文献

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{{ truncateString('EDGAR A ARRIAGA', 18)}}的其他基金

Subcellular Analysis of Caenohabdibtis elegans Aging Models
秀丽隐杆线虫衰老模型的亚细胞分析
  • 批准号:
    8457310
  • 财政年份:
    2013
  • 资助金额:
    $ 44.88万
  • 项目类别:
Functional Proteomics of Aging
衰老的功能蛋白质组学
  • 批准号:
    10430135
  • 财政年份:
    2008
  • 资助金额:
    $ 44.88万
  • 项目类别:
Functional Multi-omics of Aging
衰老的功能多组学
  • 批准号:
    10628153
  • 财政年份:
    2008
  • 资助金额:
    $ 44.88万
  • 项目类别:
Aging of the subcellular muscle proteome
亚细胞肌肉蛋白质组的衰老
  • 批准号:
    6862984
  • 财政年份:
    2004
  • 资助金额:
    $ 44.88万
  • 项目类别:
Aging of the subcellular muscle proteome
亚细胞肌肉蛋白质组的衰老
  • 批准号:
    6950861
  • 财政年份:
    2004
  • 资助金额:
    $ 44.88万
  • 项目类别:
Heteroplasmy at the single mitochondrion level
单线粒体水平的异质性
  • 批准号:
    6724792
  • 财政年份:
    2003
  • 资助金额:
    $ 44.88万
  • 项目类别:
Heteroplasmy at the single mitochondrion level
单线粒体水平的异质性
  • 批准号:
    7025013
  • 财政年份:
    2003
  • 资助金额:
    $ 44.88万
  • 项目类别:
Heteroplasmy at the single mitochondrion level
单线粒体水平的异质性
  • 批准号:
    7214732
  • 财政年份:
    2003
  • 资助金额:
    $ 44.88万
  • 项目类别:
Heteroplasmy at the single mitochondrion level
单线粒体水平的异质性
  • 批准号:
    6556403
  • 财政年份:
    2003
  • 资助金额:
    $ 44.88万
  • 项目类别:
Heteroplasmy at the single mitochondrion level
单线粒体水平的异质性
  • 批准号:
    6877114
  • 财政年份:
    2003
  • 资助金额:
    $ 44.88万
  • 项目类别:

相似海外基金

Quantitative Proteomics to Develop Robust Senescence-Related Biomarkers for Aging
定量蛋白质组学开发强大的衰老相关生物标志物
  • 批准号:
    9906152
  • 财政年份:
    2018
  • 资助金额:
    $ 44.88万
  • 项目类别:
Quantitative Proteomics to Develop Robust Senescence-Related Biomarkers for Aging
定量蛋白质组学开发强大的衰老相关生物标志物
  • 批准号:
    10403934
  • 财政年份:
    2018
  • 资助金额:
    $ 44.88万
  • 项目类别:
Monitoring the aging lung using genomics, proteomics and informatics
利用基因组学、蛋白质组学和信息学监测肺部老化
  • 批准号:
    10620762
  • 财政年份:
    2015
  • 资助金额:
    $ 44.88万
  • 项目类别:
Monitoring the aging lung using genomics, proteomics and informatics
利用基因组学、蛋白质组学和信息学监测肺部老化
  • 批准号:
    10417057
  • 财政年份:
    2015
  • 资助金额:
    $ 44.88万
  • 项目类别:
Monitoring the aging lung using genomics, proteomics and informatics
利用基因组学、蛋白质组学和信息学监测肺部老化
  • 批准号:
    10197740
  • 财政年份:
    2015
  • 资助金额:
    $ 44.88万
  • 项目类别:
A Proteomics Approach to Explore the Indicators of Photo-Aging from Human Skin: Identification of Novel Biomarker Candidates and Development of an Estimation Method for Photo-Damaged Levels.
探索人类皮肤光老化指标的蛋白质组学方法:新型生物标志物候选物的鉴定和光损伤水平估计方法的开发。
  • 批准号:
    26860909
  • 财政年份:
    2014
  • 资助金额:
    $ 44.88万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
Proteomics of memory: Normal brain aging and Alzheimers Disease
记忆蛋白质组学:正常大脑衰老和阿尔茨海默病
  • 批准号:
    8443792
  • 财政年份:
    2012
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    $ 44.88万
  • 项目类别:
Targeted Proteomics of Resilient Cognition in Aging
衰老过程中弹性认知的靶向蛋白质组学
  • 批准号:
    8449147
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    2011
  • 资助金额:
    $ 44.88万
  • 项目类别:
Targeted Proteomics of Resilient Cognition in Aging
衰老过程中弹性认知的靶向蛋白质组学
  • 批准号:
    8837761
  • 财政年份:
    2011
  • 资助金额:
    $ 44.88万
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Targeted Proteomics of Resilient Cognition in Aging
衰老过程中弹性认知的靶向蛋白质组学
  • 批准号:
    8828052
  • 财政年份:
    2011
  • 资助金额:
    $ 44.88万
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