Functional Proteomics of Aging

衰老的功能蛋白质组学

• 批准号: 9927539
• 负责人: EDGAR A ARRIAGA
• 金额: $ 44.88万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9927539
• 关键词: Aging; Proteomics

Abstract/Summary A group of investigators at the University of Minnesota seeks to renew “Functional Proteomics of Aging”, a Training Program that helps exceptional young scientists develop the intellectual and technical tools needed for productive careers as independent investigators and educators in aging research. The program has supported annually 4 predoctoral and 2 postdoctoral trainees. The Training Program is in its 10th year of funding and has trained 16 predoctoral and 9 postdoctoral trainees, who have successful careers. In addition to the research conducted in the mentor’s laboratory, trainees receive didactic (4 courses, 2 workshops) and experiential training in gerontology and proteomics (conferences, seminars, symposia, journal clubs, group meetings with Program faculty members, and a new visitorship program to Nathan Shock Centers). The experiential training is designed to maximize interaction among trainees and Training faculty from multiple labs and with scientists involved in aging research outside the U of MN. Faculty mentors draw trainees from six graduate programs at the University of Minnesota: Biochemistry, Molecular Biology and Biophysics (BMBB), Chemistry (Chem), Experimental and Clinical Pharmacology (ECP), Integrative Biology and Physiology (IBP) and Neuroscience (NSc), and Rehabilitation Sciences (RSc). The mentors’ research programs focus on the use proteomic and other advanced state-of-the-art technologies to reveal the molecular details behind the age- related loss in tissue function and/or age-related disease and are conceptually organized into four foci: loss of muscle function with age and disease, decline of the central nervous system with age and disease, the metabolism and signaling of aging and longevity, and development of technology for the advancement of aging research. Our research is supported by outstanding cores equipped with a variety of state-of-the-art mass spectrometers in the Center for Mass Spectrometry and Proteomics and bioinformatics platforms in the Minnesota Supercomputers Institute. Training faculty laboratories also contain specialized analytical equipment that is commonly shared between Program faculty. Together, the cadre of distinguished mentors, the extensive interdisciplinary collaborations among faculty and trainees of multiple departments, the technological resources, and the didactic and experiential training helps our trainees to shape successful careers.

摘要/概要 明尼苏达大学的一组研究人员试图更新“衰老的功能蛋白质组学”， 培训计划，帮助杰出的年轻科学家开发所需的知识和技术工具 作为老龄化研究的独立调查员和教育工作者的富有成效的职业生涯。该计划已 每年资助4名博士前和2名博士后学员。该培训计划已进入第10个年头， 资助并培养了16名博士前和9名博士后学员，他们都有成功的职业生涯。此外 在导师实验室进行的研究中，学员接受教学（4门课程，2个讲习班）， 老年学和蛋白质组学的经验培训（会议，研讨会，专题讨论会，期刊俱乐部，小组 与计划教师的会议，和一个新的访问计划，以内森休克中心）。的 体验式培训旨在最大限度地提高学员与来自多个实验室的培训教员之间的互动 以及明尼苏达大学以外从事衰老研究的科学家。教师导师从六个 明尼苏达大学的研究生课程：生物化学，分子生物学和生物物理学（BMBB）， 化学（化学），实验和临床药理学（ECP），综合生物学和生理学（IBP） 神经科学（NSc）和康复科学（RSc）。导师们的研究项目侧重于 使用蛋白质组学和其他先进的最先进的技术来揭示年龄背后的分子细节- 组织功能的丧失和/或年龄相关疾病，并在概念上分为四个病灶： 肌肉功能随着年龄和疾病，中枢神经系统随着年龄和疾病的下降， 衰老和长寿的代谢和信号，以及促进衰老的技术发展 research.我们的研究得到了配备各种最先进质量的优秀核心的支持。 质谱和蛋白质组学中心的质谱仪和生物信息学平台， 明尼苏达超级计算机研究所。培训学院的实验室还包括专门的分析设备 这是程序教师之间共享的。在一起，杰出的导师干部，广泛的 教师和多个部门的学员之间的跨学科合作，技术 资源，以及教学和体验培训帮助我们的学员塑造成功的职业生涯。