Functional Multi-omics of Aging

衰老的功能多组学

• 批准号: 10628153
• 负责人: EDGAR A ARRIAGA
• 金额: $ 49.47万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2028-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628153
• 关键词: Aging; multiple omics

Project Summary / Abstract A group of principal investigators at the University of Minnesota seeks to renew our Training Program under the new title “Functional Multi-omics of Aging” to support predoctoral and postdoctoral trainees. The goal of the Training Program is to assist exceptional young scientists develop the intellectual and technical skills needed for productive careers as biomedical researchers and educators in aging biology with a focus on training in -omics technologies. The Training Program is in its 14th year of funding and has trained 23 pre- and 15 post-doctoral trainees. Didactic training occurs through four T32-led courses covering fundamental biology that drives aging, the Geroscience Hypothesis of Aging, emerging -omics technologies in aging research, and professional development to prepare trainees for the next step in their scientific careers. Novel to this funding period, the Training Program will interface with the newly established and continually expanding Institute on the Biology of Aging and Metabolism (iBAM) at the University of Minnesota to further provide trainees experiential training in the biology of aging and multi-omics through workshops, conferences, seminars, symposia, journal clubs, and a visitorship program. Through iBAM, our institution has recruited internationally prominent researchers in aging biology and with this explosion of energy and ideas, our training faculty has grown from 19 to 23, diversifying rank, background, and departmental homes. Training faculty research focuses on the use of -omics technologies to reveal the molecular details behind aging and they draw trainees from five graduate programs: Biochemistry, Molecular Biology and Biophysics, Chemistry, Integrative Biology & Physiology, Neuroscience, and Rehabilitation Science. New leadership of this T32 takes on an MPI structure to capture the breadth of needs with Drs. Arriaga, Lowe, and Niedernhofer synergizing their expertise in graduate education, -omics technology, aging research, and professional development. Our aging research is supported by outstanding genomics, proteomics, and imaging cores at UMN equipped with state-of-the-art single cell and spatial transcriptomics and proteomics platforms. These new developments have led to an even stronger Training Program as measured by the publication records and research career success of past trainees as well as the funding and training records of Training Program faculty. Together, the team of distinguished mentors, the extensive interdisciplinary collaborations among faculty and trainees from multiple departments, the technological resources, and the didactic and experiential training helps our trainees to shape successful careers in aging research.

项目概要/摘要 明尼苏达大学的一组主要研究人员寻求根据以下规定更新我们的培训计划 新标题“衰老的功能性多组学”为博士前和博士后学员提供支持。的目标 培训计划旨在帮助杰出的年轻科学家发展所需的智力和技术技能 作为衰老生物学领域的生物医学研究人员和教育工作者，重点关注组学培训，取得富有成效的职业生涯 技术。该培训计划已进入第 14 个资助年头，已培训了 23 名博士前和 15 名博士后 实习生。教学培训通过四门 T32 主导的课程进行，涵盖驱动衰老的基础生物学、 衰老的老年科学假说、衰老研究中的新兴组学技术以及专业 发展，为学员的科学职业生涯的下一步做好准备。本次资助期间的新颖之处在于 培训计划将与新成立并不断扩大的生物学研究所对接 明尼苏达大学衰老与代谢（iBAM）进一步为学员提供以下方面的体验式培训 通过讲习班、会议、研讨会、专题讨论会、期刊俱乐部和 访问计划。通过 iBAM，我们的机构招募了国际知名的老龄化研究人员 随着能量和思想的爆发，我们的培训师从 19 名增加到 23 名，实现了多元化 等级、背景和部门所在地。培训教师研究的重点是组学技术的使用 为了揭示衰老背后的分子细节，他们从五个研究生项目中吸引了学员：生物化学、 分子生物学和生物物理学、化学、综合生物学和生理学、神经科学和 康复科学。 T32 的新领导层采用 MPI 结构来捕捉广泛的需求 与博士。 Arriaga、Lowe 和 Niedernhofer 协同他们在研究生教育、组学技术、 老龄化研究和专业发展。我们的衰老研究得到了杰出基因组学的支持， UMN 的蛋白质组学和成像核心配备了最先进的单细胞和空间转录组学， 蛋白质组学平台。这些新发展带来了更强大的培训计划（经测量） 通过过去受训者的出版记录和研究职业成功以及资金和培训 培训计划教师的记录。杰出的导师团队、广泛的跨学科共同努力 来自多个部门的教师和学员之间的合作、技术资源和 教学和体验式培训帮助我们的学员在衰老研究领域塑造成功的职业生涯。

项目成果

Inflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration.

• DOI: 10.3390/cells11132075
• 发表时间: 2022-06-30
• 期刊: Cells
• 影响因子: 6

Nucleotide- and Protein-Dependent Functions of Actg1.

• DOI: 10.1091/mbc.e22-02-0054
• 发表时间: 2022-08-01
• 期刊: MOLECULAR BIOLOGY OF THE CELL
• 影响因子: 3.3
• 作者: Sundby, Lauren J.;Southern, William M.;Hawbaker, Katelin M.;Trujillo, Jesus M.;Perrin, Benjamin J.;Ervasti, James M.
• 通讯作者: Ervasti, James M.

Perspective on AMD Pathobiology: A Bioenergetic Crisis in the RPE.

• DOI: 10.1167/iovs.18-24289
• 发表时间: 2018-03-20
• 期刊: Investigative ophthalmology & visual science
• 影响因子: 4.4
• 作者: Fisher CR;Ferrington DA
• 通讯作者: Ferrington DA

Orthogonal Enzyme-Substrate Design Strategy for Discovery of Human Protein Palmitoyltransferase Substrates.

• DOI: 10.1021/jacs.3c04359
• 发表时间: 2023-10-18
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Puthenveetil, Robbins;Auger, Shelby A.;Gomez-Navarro, Natalia;Rana, Mitra Shumsher;Das, Riki;Healy, Liam Brendan;Suazo, Kiall F.;Shi, Zhen-Dan;Swenson, Rolf E.;Distefano, Mark D.;Banerjee, Anirban
• 通讯作者: Banerjee, Anirban

The Role of Senescent Cells in Acquired Drug Resistance and Secondary Cancer in BRAFi-Treated Melanoma.

• DOI: 10.3390/cancers13092241
• 发表时间: 2021-05-07
• 期刊: Cancers
• 影响因子: 5.2
• 作者: Thompson EL;Hu JJ;Niedernhofer LJ
• 通讯作者: Niedernhofer LJ