Associations of Sleep Duration and Dynamics with Biomarkers of Cardiometabolic Diseases; A micro-longitudinal Approach

摘要 K01指导职业发展奖的PI是一名专注于交叉点的初级调查员 流行病学、睡眠医学和妇女健康之间的关系。她研究了睡眠对健康的影响，使用 当代分析方法。她的职业目标是增进对 睡眠不足会损害女性的心脏代谢健康。拟议的K01指导职业发展 该奖项包括一项为期5年的培训、教育和研究目标计划，旨在提供技能和经验 私家侦探需要成为一名非常成功和独立的调查员。 睡眠不足是一个主要的公共健康负担，与心脏代谢性疾病的发病率和死亡率有关。更多女性 比男人睡眠更差。这些性别差异可能是基于内分泌的。事实上，睡眠随着时间的推移而变化 月经周期，但这些睡眠变化是否会影响心脏新陈代谢健康尚不清楚。这 研究将利用先进的流行病学方法，对以下途径产生洞察和假设 绝经前妇女的睡眠和心脏代谢性疾病之间的联系。 候选人将研究睡眠模式和临床相关指标之间的联系。 心脏代谢疾病。为了实现这些目标，候选人将利用来自BioCycle的现有数据 研究不同种族的年轻女性。随着独特的微纵向设计，BioCycle的研究紧随其后 妇女连续两次月经周期。收集的信息包括人口统计数据， 病史、人体测量和血液、唾液、尿液和每日睡眠日记的系列评估 条目。 这项指导研究科学家职业生涯奖将集中于三个学习目标：1)教学教育 睡眠生理学和神经生物学；2)生物标志物评估和分析方面的培训；3)授课教育 以及高级定量方法的培训及其在睡眠研究中的应用。 PI将由一支卓有成效的、专门定制的、多学科指导团队提供支持。她 还将受益于密歇根医学、其睡眠医学部和 公共卫生学院，在睡眠研究方面开展了许多富有成效和有影响力的职业。

Abstract The PI for this K01 mentored career development award is a junior investigator focused on the intersection between epidemiology, sleep medicine, and women’s health. She examines the impact of sleep on health, using contemporary analytical approaches. Her career goal is to advance understanding of pathways through which inadequate sleep impairs cardiometabolic health in women. The proposed K01 mentored career development award includes a 5-year plan for training, education, and research aims that will provide the skills and experience the PI needs to become a highly successful and independent investigator. Insufficient sleep is a major public health burden, linked to cardiometabolic morbidity and mortality. More women experience poor sleep than men. These sex differences are likely endocrine-based. Indeed, sleep varies along the menstrual cycle, but whether these sleep variations affect cardiometabolic health remains unknown. This study will harness advanced epidemiologic methods to generate insight and hypothesis on the pathways that link sleep and cardiometabolic diseases in premenopausal women. The candidate will examine associations between patterns of sleep and clinically-relevant markers of cardiometabolic diseases. To accomplish these aims, the candidate will utilize existing data from the BioCycle study of young and racially diverse women. With a unique micro-longitudinal design, the BioCycle study followed women serially along two consecutive menstrual cycles. Collected information includes demographic data, medical history, anthropometric measures and serial assessments of blood, saliva, urine, and daily sleep diary entries. This mentored research scientist career award will focus on three learning objectives: 1) didactic education in sleep physiology and neurobiology; 2) training in biomarker assessment and analysis; and 3) didactic education and training in advanced quantitative methods and their application in sleep research. The PI will be supported by an accomplished, specifically-tailored and multidisciplinary mentorship team. She will also benefit from superb research infrastructure at Michigan Medicine, its Division of Sleep Medicine and the School of Public Health, which has launched many productive and impactful careers in sleep research.