Associations of Sleep Duration and Dynamics with Biomarkers of Cardiometabolic Diseases; A micro-longitudinal Approach

摘要 该K 01指导职业发展奖的PI是一名专注于交叉点的初级调查员 流行病学、睡眠医学和女性健康之间的联系。她研究了睡眠对健康的影响， 现代分析方法。她的职业目标是促进对途径的理解， 睡眠不足损害妇女的心脏代谢健康。拟议的K 01指导职业发展 该奖项包括一个为期5年的培训，教育和研究目标，将提供技能和经验的计划 PI需要成为一个非常成功和独立的调查员。 睡眠不足是一个主要的公共卫生负担，与心脏代谢发病率和死亡率有关。更多的妇女 睡眠质量比男性差。这些性别差异可能是基于内分泌的。事实上，睡眠沿着 这些睡眠变化与月经周期有关，但这些睡眠变化是否会影响心脏代谢健康仍不清楚。这 这项研究将利用先进的流行病学方法，对 睡眠与绝经前妇女心脏代谢疾病的关系。 候选人将检查睡眠模式与临床相关的睡眠标志物之间的关联。 心脏代谢疾病为了实现这些目标，候选人将利用生物循环的现有数据 对年轻女性和不同种族女性的研究。凭借独特的微纵向设计，BioCycle研究遵循 连续沿着两个月经周期的妇女。收集的信息包括人口统计数据， 病史、人体测量和血液、唾液、尿液和每日睡眠日记的系列评估 条目 这个指导研究科学家职业奖将集中在三个学习目标：1）教学教育， 睡眠生理学和神经生物学; 2）生物标志物评估和分析培训; 3）教学教育 以及先进的定量方法及其在睡眠研究中的应用的培训。 PI将得到一个有成就的，专门定制的和多学科的导师团队的支持。她 也将受益于密歇根医学，其睡眠医学部门和 公共卫生学院，在睡眠研究方面推出了许多富有成效和影响力的职业。

Abstract The PI for this K01 mentored career development award is a junior investigator focused on the intersection between epidemiology, sleep medicine, and women’s health. She examines the impact of sleep on health, using contemporary analytical approaches. Her career goal is to advance understanding of pathways through which inadequate sleep impairs cardiometabolic health in women. The proposed K01 mentored career development award includes a 5-year plan for training, education, and research aims that will provide the skills and experience the PI needs to become a highly successful and independent investigator. Insufficient sleep is a major public health burden, linked to cardiometabolic morbidity and mortality. More women experience poor sleep than men. These sex differences are likely endocrine-based. Indeed, sleep varies along the menstrual cycle, but whether these sleep variations affect cardiometabolic health remains unknown. This study will harness advanced epidemiologic methods to generate insight and hypothesis on the pathways that link sleep and cardiometabolic diseases in premenopausal women. The candidate will examine associations between patterns of sleep and clinically-relevant markers of cardiometabolic diseases. To accomplish these aims, the candidate will utilize existing data from the BioCycle study of young and racially diverse women. With a unique micro-longitudinal design, the BioCycle study followed women serially along two consecutive menstrual cycles. Collected information includes demographic data, medical history, anthropometric measures and serial assessments of blood, saliva, urine, and daily sleep diary entries. This mentored research scientist career award will focus on three learning objectives: 1) didactic education in sleep physiology and neurobiology; 2) training in biomarker assessment and analysis; and 3) didactic education and training in advanced quantitative methods and their application in sleep research. The PI will be supported by an accomplished, specifically-tailored and multidisciplinary mentorship team. She will also benefit from superb research infrastructure at Michigan Medicine, its Division of Sleep Medicine and the School of Public Health, which has launched many productive and impactful careers in sleep research.