Associations of Sleep Duration and Dynamics with Biomarkers of Cardiometabolic Diseases; A micro-longitudinal Approach

睡眠持续时间和动态与心脏代谢疾病生物标志物的关联；

• 批准号: 10675474
• 负责人: Galit Levi Dunietz
• 金额: $ 9.47万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10675474
• 关键词: Adult; Affect; American; Animals; Award; Biological Markers; Blood; Body Composition; Body fat; Body mass index; C-reactive protein; Cardiometabolic Disease; Chronic; Cross-Sectional Studies; Data; Dual-Energy X-Ray Absorptiometry; Education; Endocrine; Endothelium; Epidemiologic Methods; Epidemiologist; Epidemiology; Fatty acid glycerol esters; Funding; Glucose; Goals; Health; Home; Hour; Human; Individual; Insulin; K-Series Research Career Programs; Laboratories; Learning; Leg; Link; Lipids; Longitudinal Studies; Longitudinal cohort; Measurement; Measures; Medical; Medical History; Medicine; Menstrual cycle; Mentors; Mentorship; Metabolic; Metabolism; Methods; Michigan; Minority Women; Morbidity - disease rate; Neurobiology; Obesity; Overweight; Oxidative Stress; Pathway interactions; Pattern; Plasma; Positioning Attribute; Premenopause; Productivity; Puberty; Public Health; Public Health Schools; Reporting; Research; Research Infrastructure; Research Personnel; Rodent; Saliva; Scanning; Scientist; Sex Differences; Sleep; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Statistical Methods; Thinness; Time; Training; Training and Education; Up-Regulation; Urine; Variant; Visceral fat; Weight; Woman; Women' s Health; aged; animal data; cardiometabolism; career; clinically relevant; cohort; cost; design; diaries; didactic education; experience; fasting glucose; innovation; insight; longitudinal design; men; mortality; multidisciplinary; novel; orexin A; poor sleep; potential biomarker; racial diversity; research study; sex; skills; sleep pattern; sleep physiology; sleep regulation; young woman

Abstract The PI for this K01 mentored career development award is a junior investigator focused on the intersection between epidemiology, sleep medicine, and women’s health. She examines the impact of sleep on health, using contemporary analytical approaches. Her career goal is to advance understanding of pathways through which inadequate sleep impairs cardiometabolic health in women. The proposed K01 mentored career development award includes a 5-year plan for training, education, and research aims that will provide the skills and experience the PI needs to become a highly successful and independent investigator. Insufficient sleep is a major public health burden, linked to cardiometabolic morbidity and mortality. More women experience poor sleep than men. These sex differences are likely endocrine-based. Indeed, sleep varies along the menstrual cycle, but whether these sleep variations affect cardiometabolic health remains unknown. This study will harness advanced epidemiologic methods to generate insight and hypothesis on the pathways that link sleep and cardiometabolic diseases in premenopausal women. The candidate will examine associations between patterns of sleep and clinically-relevant markers of cardiometabolic diseases. To accomplish these aims, the candidate will utilize existing data from the BioCycle study of young and racially diverse women. With a unique micro-longitudinal design, the BioCycle study followed women serially along two consecutive menstrual cycles. Collected information includes demographic data, medical history, anthropometric measures and serial assessments of blood, saliva, urine, and daily sleep diary entries. This mentored research scientist career award will focus on three learning objectives: 1) didactic education in sleep physiology and neurobiology; 2) training in biomarker assessment and analysis; and 3) didactic education and training in advanced quantitative methods and their application in sleep research. The PI will be supported by an accomplished, specifically-tailored and multidisciplinary mentorship team. She will also benefit from superb research infrastructure at Michigan Medicine, its Division of Sleep Medicine and the School of Public Health, which has launched many productive and impactful careers in sleep research.

抽象的 K01 指导职业发展奖的 PI 是一位专注于交叉领域的初级研究员 流行病学、睡眠医学和女性健康之间的关系。她研究了睡眠对健康的影响，利用 当代的分析方法。她的职业目标是增进对途径的理解 睡眠不足会损害女性的心脏代谢健康。拟议的K01指导职业发展 奖项包括为期五年的培训、教育和研究计划，旨在提供技能和经验 PI 需要成为一名非常成功且独立的调查员。 睡眠不足是主要的公共卫生负担，与心脏代谢发病率和死亡率有关。更多女性 睡眠质量比男性差。这些性别差异可能是基于内分泌的。事实上，睡眠会随着时间的推移而变化 月经周期，但这些睡眠变化是否影响心脏代谢健康仍不清楚。这 研究将利用先进的流行病学方法来产生关于途径的见解和假设 将绝经前女性的睡眠与心脏代谢疾病联系起来。 考生将检查睡眠模式与临床相关标记物之间的关联。 心脏代谢疾病。为了实现这些目标，候选人将利用 BioCycle 的现有数据 对年轻和不同种族女性的研究。凭借独特的微纵向设计，BioCycle 研究遵循 女性连续两个月经周期。收集的信息包括人口统计数据、 病史、人体测量以及血液、唾液、尿液和每日睡眠日记的连续评估 条目。 这个受指导的研究科学家职业奖将重点关注三个学习目标：1） 睡眠生理学和神经生物学； 2）生物标志物评估和分析培训； 3）教学教育 以及先进定量方法及其在睡眠研究中的应用的培训。 PI 将得到一支经验丰富、专门定制的多学科指导团队的支持。她 还将受益于密歇根医学及其睡眠医学部和 公共卫生学院在睡眠研究领域开展了许多富有成效和影响力的职业。

项目成果

Associations of plasma hypocretin-1 with metabolic and reproductive health: Two systematic reviews of clinical studies.

• DOI: 10.1016/j.smrv.2020.101307
• 发表时间: 2020-03
• 期刊: Sleep medicine reviews
• 影响因子: 10.5
• 作者: G. Dunietz;G. Vanini;C. Shannon;L. O’Brien;R. Chervin

Associations Between Transgender Identity, Sleep, Mental Health and Suicidality Among a North American Cohort of College Students.

• DOI: 10.2147/nss.s286131
• 发表时间: 2021
• 期刊: Nature and science of sleep
• 影响因子: 3.4
• 作者: Hershner S;Jansen EC;Gavidia R;Matlen L;Hoban M;Dunietz GL
• 通讯作者: Dunietz GL

Objective sleep duration and timing predicts completion of in vitro fertilization cycle.

客观睡眠持续时间和时间可预测体外受精周期的完成。

• DOI: 10.1007/s10815-021-02260-8
• 发表时间: 2021
• 期刊: Journal of assisted reproduction and genetics
• 影响因子: 3.1
• 作者: Pimolsri,Chawanont;Lyu,Xiru;Goldstein,Cathy;Fortin,ChelseaN;Mumford,SunniL;Smith,YolandaR;Lanham,MichaelS;O'Brien,LouiseM;Dunietz,GalitLevi
• 通讯作者: Dunietz,GalitLevi

Respiratory infection risk in positive airway pressure therapy users: a retrospective cohort study.

气道正压通气治疗使用者的呼吸道感染风险：一项回顾性队列研究。

• DOI: 10.5664/jcsm.10670
• 发表时间: 2023
• 期刊: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
• 作者: Gavidia,Ronald;Shieu,MonicaM;Dunietz,GalitLevi;Braley,TiffanyJ
• 通讯作者: Braley,TiffanyJ