Administrative Core

近三分之二的美国人临床上超重或肥胖，近10%的人 该人群患有成人发病的糖尿病。肥胖和糖尿病是一组疾病的核心因素 这些疾病统称为“代谢综合征”。我们的生物医学中心 彭宁顿生物医学研究中心的卓越研究(Cobre)正在领导一项 通过指导我们最有前途的年轻人来加强对代谢性疾病的研究 由该中心内的资深科学家向科学家提供独立性。所承担的工作范围 科布雷的科学家们包含了细胞、分子和翻译的组合 解决问题的方法从葡萄糖传感的神经机制和 能量动态平衡，与脂肪生成相关的炎症机制，表观遗传学 程序在肥胖中的作用，脂肪细胞线粒体生物发生的调节，以及 炎症对胰岛β细胞功能的影响。我们的科布雷已经开发出了科学 通过建立最先进的基础设施来支持这些不同目标的追求 基因组学、细胞生物学和生物成像，以及转基因核心。我们的具体目标是 Cobre在第三阶段将进一步扩大参与的生产性调查人员的临界数量 在肥胖/糖尿病研究方面：(A)从内部培养和留住优秀的初级教员 该机构并指导他们获得可持续的独立资助(B)招募优秀的初级学生 和从事代谢性疾病研究的高级教员，这些研究补充了现有的 中心调查人员；(C)开发和培育新的机会，以便与 机构同事，通过制定新的试点和可行性筹资方案，(D)加强 利用细胞生物学和生物科学研究所开发的优秀研究基础设施 生物成像、基因组学和转基因核心设施在第三阶段通过开发 培训单元和外联活动。衡量成功的关键指标是扩大 科布雷教员获得的校外助学金数量，增加教员数量 从事代谢性疾病研究，利用Cobre支持扩展我们的 通过增加对机构资源的利用和投资，形成科学核心。

Nearly two-thirds of the US population is either clinically overweight or obese and almost 10% of the population has adult-onset diabetes. Obesity and diabetes are central elements of a cluster of pathologies collectively referred to as "metabolic syndrome". Our Center of Biomedical Research Excellence (COBRE) at the Pennington Biomedical Research Center is leading an effort to enhance research on metabolic disease by mentoring our most promising young scientists to independence by senior scientists within the Center. The scope of work undertaken by COBRE scientists encompasses a combination of cellular, molecular, and translational approaches to address questions ranging from neural mechanisms of glucose sensing and energy homeostasis, inflammatory mechanisms linked to adipogenesis, epigenetic programming in obesity, regulation of mitochondrial biogenesis in adipocytes, and the role of inflammation in pancreatic beta cell function. Our COBRE has developed the scientific infrastructure to support the pursuit of these diverse objectives by establishing state of the art Genomics, Cell Biology and Bioimaging, and Transgenic Cores. The Specific Aims of our COBRE in Phase III are to further expand the critical mass of productive investigators engaged in obesity/diabetes research by (a) develop and retain outstanding new junior faculty from within the institution and mentor them to sustainable independent funding (b) recruit outstanding junior and senior faculty engaged in metabolic disease research that complement existing strengths of Center investigators; (c) develop and foster new opportunities for collaborative interactions with institutional colleagues by instituting a new Pilot and Feasibility funding program, (d) enhance utilization of the outstanding research infrastructure developed within the Cell Biology and Bioimaging, Genomics, and Transgenic core facilities in Phase III through development of training modules and outreach activites. The critical metrics of success are to expand the number of extramural grants obtained by the COBRE faculty, increase the number of faculty engaged in metabolic diseases research, leverage COBRE support to expand the quality of our scientific cores through increased utilization and investment of institutional resources.