Administrative Core

近三分之二的美国人口临床上超重或肥胖，近10%的人 成人糖尿病发病率很高肥胖和糖尿病是一个集群的核心要素 统称为"代谢综合征"的病理学。我们的生物医学中心 彭宁顿生物医学研究中心的卓越研究（COBRE）正在领导一项 通过指导我们最有前途的年轻人，努力加强代谢疾病的研究 科学家独立的中心内的资深科学家。开展的工作范围 COBRE科学家的研究包括细胞、分子和翻译的组合， 解决葡萄糖感知的神经机制和 能量稳态，与脂肪形成相关的炎症机制，表观遗传 肥胖症中的编程，脂肪细胞中线粒体生物发生的调节，以及 胰腺β细胞功能的炎症。我们的眼镜蛇已经开发出了 通过建立最先进的基础设施，支持实现这些不同的目标 基因组学、细胞生物学和生物成像以及转基因核心。我们的具体目标 COBRE在第三阶段将进一步扩大从事生产调查的临界质量 在肥胖/糖尿病研究中，（a）从内部培养和留住优秀的新的初级教员 该机构并指导他们可持续独立资助（B）招聘优秀的初级 和从事代谢疾病研究的高级教师，补充现有的优势， （c）开发和促进与中心研究人员合作互动的新机会; 通过建立一个新的试点和可行性资助计划，（d）加强 利用细胞生物学中开发的优秀研究基础设施， 生物成像、基因组学和转基因核心设施在第三阶段通过发展 培训单元和外联活动。成功的关键指标是扩大 COBRE教师获得的校外补助金数量，增加教师数量 从事代谢疾病研究，利用COBRE的支持，扩大我们的质量， 通过增加机构资源的利用和投资，建立科学核心。

Nearly two-thirds of the US population is either clinically overweight or obese and almost 10% of the population has adult-onset diabetes. Obesity and diabetes are central elements of a cluster of pathologies collectively referred to as "metabolic syndrome". Our Center of Biomedical Research Excellence (COBRE) at the Pennington Biomedical Research Center is leading an effort to enhance research on metabolic disease by mentoring our most promising young scientists to independence by senior scientists within the Center. The scope of work undertaken by COBRE scientists encompasses a combination of cellular, molecular, and translational approaches to address questions ranging from neural mechanisms of glucose sensing and energy homeostasis, inflammatory mechanisms linked to adipogenesis, epigenetic programming in obesity, regulation of mitochondrial biogenesis in adipocytes, and the role of inflammation in pancreatic beta cell function. Our COBRE has developed the scientific infrastructure to support the pursuit of these diverse objectives by establishing state of the art Genomics, Cell Biology and Bioimaging, and Transgenic Cores. The Specific Aims of our COBRE in Phase III are to further expand the critical mass of productive investigators engaged in obesity/diabetes research by (a) develop and retain outstanding new junior faculty from within the institution and mentor them to sustainable independent funding (b) recruit outstanding junior and senior faculty engaged in metabolic disease research that complement existing strengths of Center investigators; (c) develop and foster new opportunities for collaborative interactions with institutional colleagues by instituting a new Pilot and Feasibility funding program, (d) enhance utilization of the outstanding research infrastructure developed within the Cell Biology and Bioimaging, Genomics, and Transgenic core facilities in Phase III through development of training modules and outreach activites. The critical metrics of success are to expand the number of extramural grants obtained by the COBRE faculty, increase the number of faculty engaged in metabolic diseases research, leverage COBRE support to expand the quality of our scientific cores through increased utilization and investment of institutional resources.