Mentoring Obesity and Diabetes Research in Louisiana

指导路易斯安那州的肥胖和糖尿病研究

• 批准号: 9320355
• 负责人: Thomas W Gettys
• 金额: $ 20.98万
• 依托单位: LSU PENNINGTON BIOMEDICAL RESEARCH CTR
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9320355
• 关键词: Adipose tissue; Affect; Basic Science; Biochemical; Bioinformatics; Biomedical Research; Cells; Cellular biology; Centers of Research Excellence; Chronic; Chronic Disease; Clinical; Clinical Research; Core Facility; Country; Development; Diabetes Mellitus; Disease; Elements; Ensure; Environment; Event; Extramural Activities; Faculty; Fostering; Funding; Genomics; Goals; Grant; Growth; Growth and Development function; Health; High Prevalence; Homeostasis; Incidence; Institution; Interdisciplinary Study; Knowledge; Louisiana; Mentors; Metabolic Diseases; Metabolic syndrome; Mission; Molecular; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Overweight; Pathology; Phase; Pilot Projects; Population; Population Sciences; Positioning Attribute; Prevention strategy; Preventive Medicine; Process; Productivity; Public Health; Quality of life; Recording of previous events; Regulation; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Scientist; Services; Thinness; Training; Training Programs; Translating; Translational Research; United States National Institutes of Health; base; bioimaging; carbohydrate metabolism; education research; effective therapy; energy balance; improved; insight; lipid metabolism; member; novel therapeutics; nutrition; organizational structure; outreach; programs; public health relevance; success; treatment strategy

 DESCRIPTION (provided by applicant): Nearly two-thirds of the US population is either clinically overweight or obese and almost 10% of the population has adult-onset diabetes. Obesity and diabetes are central elements of a cluster of pathologies collectively referred to as "metabolic syndrome". Our Center of Biomedical Research Excellence (COBRE) at the Pennington Biomedical Research Center was established to enhance research on metabolic disease by increasing the number of extramurally-funded faculty devoted to this research and expanding the scientific infrastructure needed for its conduct. During Phases I and II of our COBRE, our Center has provided support to 15 junior faculty members who have obtained 14 NIH grants (7 RO1, 2 RO3, 1 R21, 1 R56, 2 R41, 1 R43) and 5 research grants from the ADA. In addition, the research infrastructure has been significantly improved by (1) enhancement of the Genomics Core through hardware upgrades and addition of Bioinformatics support to the core's activities, and (2) establishment of an outstanding, well equipped Cell Biology and Bio-imaging Core that has provided high levels of expertise and service to institutional faculty and Project PIs supported by our COBRE. The Specific Aims of our COBRE in Phase III are to further expand the critical mass of productive investigators engaged in metabolic disease research by (a) maintaining the highly effective mentoring culture we have built and refined during the first two phases of our Center; (b) identifying, mentoring, and retaining our most talented, well-trained junior scientists emerging from our institutional training grants; (c) continuing to enhance the growth of our scientific cores by leveraging institutional support to sustain their strong positive impact on the success of Center scientists, and (4) sustaining a collaborative multidisciplinary research environment by providing support for research pilot projects that are critical to obtaining new extramural support and sustaining the Center's basic and translational research activities.

 描述（由申请人提供）：近三分之二的美国人口在临床上超重或肥胖，近 10% 的人口患有成人糖尿病。肥胖和糖尿病是统称为“代谢综合征”的一组病理学的核心要素。我们在彭宁顿生物医学研究中心建立的生物医学研究卓越中心 (COBRE) 的目的是通过增加专门从事这项研究的外部资助教师的数量并扩大其开展所需的科学基础设施来加强代谢疾病的研究。在 COBRE 的第一和第二阶段，我们中心为 15 名初级教员提供了支持，他们获得了 14 项 NIH 资助（7 项 RO1、2 RO3、1 R21、1 R56、2 R41、1 R43）和 5 项 ADA 研究资助。此外，研究基础设施也得到了显着改善：(1) 通过硬件升级和增加对核心活动的生物信息学支持来增强基因组学核心，以及 (2) 建立了一个出色的、设备齐全的细胞生物学和生物成像核心，为我们 COBRE 支持的机构教师和项目 PI 提供了高水平的专业知识和服务。我们 COBRE 第三阶段的具体目标是通过 (a) 维持我们在中心前两个阶段建立和完善的高效指导文化； (b) 识别、指导和留住从我们的机构培训补助金中脱颖而出的最有才华、训练有素的初级科学家； (c) 通过利用机构支持来维持其对中心科学家成功的强大积极影响，继续促进我们科学核心的发展；(4) 通过为研究试点项目提供支持来维持协作的多学科研究环境，这些项目对于获得新的校外支持和维持中心的基础和转化研究活动至关重要。