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Synaptic Processing in the Olfactory System

嗅觉系统中的突触处理

基本信息

批准号：
9978037
负责人：
JEFFRY S ISAACSON
金额：
$ 36.76万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2022-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9978037
关键词：
Address Animals Brain Brain region Cells Chronic Code Cognition Disorders Cues Electrophysiology (science)Equilibrium Event Feedback Functional disorder Goals Head Human Image In Vitro Interneurons Knowledge Learning Mammals Mediating Memory Mus Neurons Neurosciences Odors Olfactory Cortex Olfactory Learning Olfactory Pathways Optics Output Parvalbumins Perception Play Population Process Property Pyramidal Cells Quality of life Research Resolution Rodent Role Schizophrenia Sensory Shapes Site Slice Smell Perception Somatostatin Synapses Synaptic Transmission System Techniques Time Vasoactive Intestinal Peptide Wakefulness Work autism spectrum disorder awake base calcium indicator cell type classical conditioning conditioned fear excitatory neuron experience experimental study extracellular in vivo in vivo imaging information processing inhibitory neuron neural circuit neuronal circuitry olfactory bulb olfactory bulb glomeruli operation optical imaging optogenetics piriform cortex presynaptic programs relating to nervous system response sensory stimulus two-photon

项目摘要

Project Summary/Abstract In humans, the sense of smell contributes significantly to our quality of life. Odors are strong cues for evoking memories of past events and olfaction plays an important role in our perception of flavor. However, the mechanisms underlying the processing and encoding of olfactory information in the brain are not clear. To address this question, we study the properties of neuronal circuits formed by excitatory and inhibitory neurons in the rodent olfactory bulb, a site where olfactory information is initially encoded in the brain. We also examine the properties of circuits in the primary olfactory (piriform) cortex, the next major level at which olfactory information is processed. Our long term goal is to understand how neural circuits ultimately give rise to sensory perception The experiments proposed employ optical and electrophysiological techniques to determine the response properties of identified neuronal populations in both the olfactory bulbs and cortex. Specific Aim 1 proposes the use of chronic, in vivo two-photon recording of activity from identified principal cells and inhibitory interneurons in the olfactory bulb of awake, head-fixed mice. We will use this approach to determine how associative learning modifies odor representations in behaving mice. We hypothesize that local interneurons play an important role in learning-related changes in olfactory bulb activity. Specific Aim 2 proposes to investigate how particular subtypes of GABAergic inhibitory interneurons modulate odor coding in piriform cortex. We combine optogenetics, brain slice and in vivo electrophysiological recordings to reveal the operations by which distinct interneuron classes govern odor-evoked activity of cortical principal cells.Together, these experiments will show how local inhibitory interneurons in the olfactory bulb and cortex regulate sensory information processing in the brain.

项目概要/摘要对于人类来说，嗅觉对我们的生活质量有重大贡献。气味是唤起对过去事件记忆的强烈线索，嗅觉在我们的记忆中起着重要作用对味道的感知。然而，处理和编码的机制大脑中的嗅觉信息并不清晰。为了解决这个问题，我们研究一下属性啮齿类动物嗅球中兴奋性和抑制性神经元形成的神经元回路嗅觉信息最初在大脑中编码。我们还检查了以下属性初级嗅觉（梨状）皮层中的回路，嗅觉信息的下一个主要级别已处理。我们的长期目标是了解神经回路最终如何产生感官知觉提出的实验采用光学和电生理技术确定两个嗅球中已识别神经元群的反应特性和皮质。具体目标 1 建议使用慢性体内双光子活动记录来自清醒、头部固定的嗅球中已识别的主细胞和抑制性中间神经元老鼠。我们将使用这种方法来确定联想学习如何改变气味行为小鼠的表征。我们假设局部中间神经元发挥重要作用与学习相关的嗅球活动变化。具体目标 2 建议研究如何 GABA能抑制性中间神经元的特定亚型调节梨状皮层的气味编码。我们结合光遗传学、脑切片和体内电生理记录来揭示不同的中间神经元类别控制皮质主体的气味诱发活动的操作这些实验将共同展示嗅球中的局部抑制性中间神经元如何皮质调节大脑中的感觉信息处理。

项目成果

期刊论文数量（20）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Presynaptic cyclic nucleotide-gated ion channels modulate neurotransmission in the mammalian olfactory bulb.

突触前环核苷酸门控离子通道调节哺乳动物嗅球的神经传递。

DOI：
10.1016/s0896-6273(03)00057-6
发表时间：
2003
期刊：
Neuron
影响因子：
16.2
作者：
Murphy,GabeJ;Isaacson,JeffryS
通讯作者：
Isaacson,JeffryS

L-type calcium channels govern calcium signaling in migrating newborn neurons in the postnatal olfactory bulb.

DOI：
10.1523/jneurosci.5333-08.2009
发表时间：
2009-02-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Darcy DP;Isaacson JS
通讯作者：
Isaacson JS

Single dendrite-targeting interneurons generate branch-specific inhibition.