2020 Meiosis Gordon Research Conference and Gordon Research Seminar

2020年减数分裂戈登研究大会暨戈登研究研讨会

• 批准号: 9980585
• 负责人: Paula Elaine Cohen
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9980585
• 关键词: Academia; Address; Aneuploidy; Animal Model; Architecture; Biological; Biological Models; Cell Cycle; Cell Cycle Checkpoint; Cell Cycle Regulation; Cell division; Cells; Cellular biology; Chromatin; Chromosome Pairing; Chromosome Segregation; Chromosomes; Collaborations; Communities; Congenital Abnormality; DNA Repair; Data; Defect; Discipline; Down Syndrome; Edward' s syndrome; Ensure; Environment; Epigenetic Process; Eukaryota; European; Event; Fostering; Functional disorder; Gene Expression; Gene Expression Regulation; Genetic Recombination; Genomic Instability; Germ Cells; Goals; Growth; Haploidy; Hour; Human; Infertility; Insecta; Institution; International; Investigation; Knowledge; Lead; Learning; Light; London; Meiosis; Meiotic Recombination; Mentors; Mentorship; Microscopy; Molecular; Names; Nature; Nematoda; North America; Oncogenes; Oral; Participant; Plants; Postdoctoral Fellow; Process; Production; Regulation; Reproduction; Reproductive Health; Research; Research Personnel; Resolution; Running; Science; Scientist; Slide; Spontaneous abortion; Time; Underrepresented Minority; Variant; Vertebrates; Woman; Work; biophysical analysis; career; catalyst; chromosome movement; college; comparative; egg; experience; faculty mentor; fascinate; fungus; genome editing; graduate student; improved; innovation; meetings; novel; peer; posters; prevent; programs; sperm cell; stillbirth; success; symposium; theories; undergraduate student

Meiosis is the specialized cell division cycle that gives rise to haploid gametes for sexual reproduction. Given the conserved nature of many of the distinct events in meiosis, there is a surprising degree of variation in meiotic regulation across sexually reproducing species. Exploring both these distinct differences and commonalities is crucial to our understanding of how meiosis is regulated to ensure the production of euploid gametes. Nowhere is this more important than in our own species, in which defects in meiosis are responsible for the extremely high rates of infertility, miscarriage, and birth defects, such as Trisomies 18 and 21 (Down syndrome). Furthermore, the meiotic program encompasses unique molecular processes underlying cell cycle control and checkpoint activation, DNA repair and recombination, chromatin architecture, chromosome movements, and gene expression. This immense complexity can inform a wide variety of biological sub- disciplines, including germ cell biology, DNA repair and cancer, gene regulation and epigenetics, and chromosome dynamics and spindle assembly, to name a few. Partial support is requested for the premier international meeting on Meiosis as part of the Gordon Research Conferences (GRC), and the accompanying trainee-led Meiosis Gordon Research Seminar (GRS), taking place at Colby-Sawyer College in New London, NH on June 7-12 and June 6-7, 2020, respectively. The goals are: (1) To harness the strength of various model systems and state-of-the-art technical approaches to shed light on the molecular mechanisms underpinning meiosis; (2) To identify novel scientific themes and collaborations that can accelerate the pace of discovery in our field; and (3) To promote an environment of inclusivity and to identify key ingredients for success of our trainees, our diversity representation, and women. The GRC will gather 180 participants to present and discuss cutting-edge, mostly unpublished research addressing critical topics in meiosis. The program comprises 9 plenary sessions that broadly address current issues in the initiation and progression of meiotic recombination, meiotic progression and cell cycle checkpoints, regulation of meiotic gene expression, chromosome pairing and synapsis, chromosome dynamics, and chromosome segregation. Four poster sessions will allow trainees to present their data and to engage in critical discussions about their work with leaders in the field. An open forum Power Hour will be convened with the aims of addressing the challenges faced by women in science, and supporting the professional growth of women in our community. The GRS consists of three plenary and two poster sessions, and will include 60 participants, including several invited faculty mentors. The GRS provides opportunities for trainees to present their work, to network, and to discuss the topics that will be covered in more depth during the GRC. Our community enjoys and promotes strong representation by women, but we will further enhance our diversity by offering attendance support to under- represented minorities, young investigators, and researchers from predominantly undergraduate institutions.

减数分裂是一个特殊的细胞分裂周期，产生用于有性生殖的单倍体配子。给定 减数分裂中许多不同事件的保守性，在减数分裂中存在令人惊讶的变异程度。 有性生殖物种的减数分裂调控。探索这两个明显的差异， 这些共性对于我们理解减数分裂是如何被调节以确保整倍体的产生至关重要 配子这一点在我们人类中最为重要，因为我们人类的减数分裂缺陷是造成这一现象的原因 不孕症、流产和出生缺陷的极高发生率，如18和21三体（Down 综合征）。此外，减数分裂程序包括独特的分子过程的基础细胞周期 控制和检查点激活，DNA修复和重组，染色质结构，染色体 运动和基因表达。这种巨大的复杂性可以为各种各样的生物亚细胞提供信息， 学科，包括生殖细胞生物学，DNA修复和癌症，基因调控和表观遗传学， 染色体动力学和纺锤体组装，仅举几例。要求为总理提供部分支助 作为戈登研究会议（GRC）一部分的减数分裂国际会议，以及伴随的 由受训者领导的减数分裂戈登研究研讨会（GRS），在新伦敦的科尔比-索耶学院举行， NH分别于2020年6月7日至12日和6月6日至7日举行。目标是：（1）利用各种力量 模型系统和最先进的技术方法来阐明分子机制 支持减数分裂;（2）确定新的科学主题和合作，可以加快 发现在我们的领域;和（3）促进包容性的环境，并确定关键因素， 我们的学员，我们的多样性代表和妇女的成功。集选区将聚集180名参与者， 目前和讨论尖端，主要是未发表的研究解决减数分裂的关键主题。的 该计划包括9个全体会议，广泛解决当前的问题，在启动和发展 减数分裂重组，减数分裂进程和细胞周期检查点，减数分裂基因表达的调节， 染色体配对和联会，染色体动力学和染色体分离。四柱 会议将使受训者能够提出他们的数据，并就他们的工作进行批判性的讨论， 领导者在外地。将召开一个公开论坛Power Hour，旨在应对挑战 面对的妇女在科学，并支持妇女在我们的社区的专业成长。档案处 包括三次全体会议和两次海报会议，将有60名与会者，包括几名受邀者。 教师导师GRS为学员提供了展示他们的工作，建立网络和讨论的机会。 将在GRC期间更深入地讨论的主题。我们的社区享受并促进强有力的 妇女代表，但我们将进一步加强我们的多样性，提供出席支持，以根据- 代表少数民族，年轻的调查人员和主要来自本科院校的研究人员。