2020 Meiosis Gordon Research Conference and Gordon Research Seminar

2020年减数分裂戈登研究大会暨戈登研究研讨会

• 批准号: 9980585
• 负责人: Paula Elaine Cohen
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9980585
• 关键词: Academia; Address; Aneuploidy; Animal Model; Architecture; Biological; Biological Models; Cell Cycle; Cell Cycle Checkpoint; Cell Cycle Regulation; Cell division; Cells; Cellular biology; Chromatin; Chromosome Pairing; Chromosome Segregation; Chromosomes; Collaborations; Communities; Congenital Abnormality; DNA Repair; Data; Defect; Discipline; Down Syndrome; Edward' s syndrome; Ensure; Environment; Epigenetic Process; Eukaryota; European; Event; Fostering; Functional disorder; Gene Expression; Gene Expression Regulation; Genetic Recombination; Genomic Instability; Germ Cells; Goals; Growth; Haploidy; Hour; Human; Infertility; Insecta; Institution; International; Investigation; Knowledge; Lead; Learning; Light; London; Meiosis; Meiotic Recombination; Mentors; Mentorship; Microscopy; Molecular; Names; Nature; Nematoda; North America; Oncogenes; Oral; Participant; Plants; Postdoctoral Fellow; Process; Production; Regulation; Reproduction; Reproductive Health; Research; Research Personnel; Resolution; Running; Science; Scientist; Slide; Spontaneous abortion; Time; Underrepresented Minority; Variant; Vertebrates; Woman; Work; biophysical analysis; career; catalyst; chromosome movement; college; comparative; egg; experience; faculty mentor; fascinate; fungus; genome editing; graduate student; improved; innovation; meetings; novel; peer; posters; prevent; programs; sperm cell; stillbirth; success; symposium; theories; undergraduate student

Meiosis is the specialized cell division cycle that gives rise to haploid gametes for sexual reproduction. Given the conserved nature of many of the distinct events in meiosis, there is a surprising degree of variation in meiotic regulation across sexually reproducing species. Exploring both these distinct differences and commonalities is crucial to our understanding of how meiosis is regulated to ensure the production of euploid gametes. Nowhere is this more important than in our own species, in which defects in meiosis are responsible for the extremely high rates of infertility, miscarriage, and birth defects, such as Trisomies 18 and 21 (Down syndrome). Furthermore, the meiotic program encompasses unique molecular processes underlying cell cycle control and checkpoint activation, DNA repair and recombination, chromatin architecture, chromosome movements, and gene expression. This immense complexity can inform a wide variety of biological sub- disciplines, including germ cell biology, DNA repair and cancer, gene regulation and epigenetics, and chromosome dynamics and spindle assembly, to name a few. Partial support is requested for the premier international meeting on Meiosis as part of the Gordon Research Conferences (GRC), and the accompanying trainee-led Meiosis Gordon Research Seminar (GRS), taking place at Colby-Sawyer College in New London, NH on June 7-12 and June 6-7, 2020, respectively. The goals are: (1) To harness the strength of various model systems and state-of-the-art technical approaches to shed light on the molecular mechanisms underpinning meiosis; (2) To identify novel scientific themes and collaborations that can accelerate the pace of discovery in our field; and (3) To promote an environment of inclusivity and to identify key ingredients for success of our trainees, our diversity representation, and women. The GRC will gather 180 participants to present and discuss cutting-edge, mostly unpublished research addressing critical topics in meiosis. The program comprises 9 plenary sessions that broadly address current issues in the initiation and progression of meiotic recombination, meiotic progression and cell cycle checkpoints, regulation of meiotic gene expression, chromosome pairing and synapsis, chromosome dynamics, and chromosome segregation. Four poster sessions will allow trainees to present their data and to engage in critical discussions about their work with leaders in the field. An open forum Power Hour will be convened with the aims of addressing the challenges faced by women in science, and supporting the professional growth of women in our community. The GRS consists of three plenary and two poster sessions, and will include 60 participants, including several invited faculty mentors. The GRS provides opportunities for trainees to present their work, to network, and to discuss the topics that will be covered in more depth during the GRC. Our community enjoys and promotes strong representation by women, but we will further enhance our diversity by offering attendance support to under- represented minorities, young investigators, and researchers from predominantly undergraduate institutions.

减数分裂是产生单倍体配子进行有性繁殖的特殊细胞分裂周期。vt.给出 减数分裂中许多不同事件的保守性，在减数分裂中有令人惊讶的变异程度 有性繁殖物种的减数分裂调控。探索这些截然不同的差异和 共性对于我们理解如何调节减数分裂以确保整倍体的产生至关重要。 配子。在我们自己的物种中，这一点最为重要，减数分裂的缺陷对此负有责任。 对于极高的不孕不育、流产和出生缺陷，如18和21三体(向下 综合症)。此外，减数分裂程序包含了细胞周期中独特的分子过程。 控制和检查点激活、DNA修复和重组、染色质结构、染色体 运动和基因表达。这种巨大的复杂性可以让各种各样的生物亚种 学科，包括生殖细胞生物学、DNA修复和癌症、基因调控和表观遗传学，以及 染色体动力学和纺锤体组装，仅举几例。要求对总理提供部分支持 关于减数分裂的国际会议，作为戈登研究会议(GRC)的一部分，以及随附的 学员领导的减数分裂戈登研究研讨会(GRS)在新伦敦的科尔比-索耶学院举行， NH分别于2020年6月7日至12日和6月6日至7日举行。目标是：(1)利用各种因素的力量 阐明分子机制的模型系统和最先进的技术方法 支持减数分裂；(2)确定新的科学主题和合作，以加快 在我们的领域中发现；和(3)促进包容性的环境，并确定关键因素 我们的受训者、我们的多样性代表和妇女的成功。GRC将召集180名参与者 介绍和讨论涉及减数分裂关键主题的前沿研究，主要是未发表的研究。这个 该方案包括9次全体会议，广泛讨论启动和进展中的当前问题 减数分裂重组，减数分裂进程和细胞周期检查点，减数分裂基因表达的调节， 染色体配对和联会、染色体动力学和染色体分离。四张海报 课程将允许学员展示他们的数据，并就他们的工作进行批判性讨论 该领域的领先者。将召开一个开放的论坛力量小时，旨在应对挑战 科学领域女性所面临的挑战，并支持我们社区中女性的职业成长。《全球资源报告》 由三次全体会议和两次海报会议组成，将有60名与会者，其中包括几名应邀出席者 教职员工导师。GRS为学员提供了展示他们的工作、建立网络和讨论的机会 将在GRC期间更深入地讨论的主题。我们的社区享有和推动强大的 由妇女担任代表，但我们将进一步加强我们的多样性，为以下人员提供出席支持 代表少数族裔、年轻研究人员和以本科生为主的机构的研究人员。