Impact of sugars on tobacco product toxicity and abuse liability

糖对烟草产品毒性和滥用倾向的影响

基本信息

  • 批准号:
    9980626
  • 负责人:
  • 金额:
    $ 43.74万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-06-01 至 2023-05-31
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY Sugars, which are present naturally in some tobacco types and are also added to cigarette tobacco filler as additives, are not included in the FDA list of harmful and potentially harmful constituents (HPHC). Existing research data suggests that sugars in tobacco filler may contribute to the harmful properties of cigarettes in three critical ways: by enhancing smoke palatability and appeal and, as precursors to aldehydes and furans in the smoke, by increasing smoke toxicity and carcinogenicity and potentially addictiveness. Therefore, sugars are potentially the most versatile key constituents contributing to the smoking-associated morbidity and mortality. However, there is lack of robust quantitative data on the relationship between tobacco sugar content and relevant toxicant yields in U.S. commercial cigarettes, and the associated user exposures, behaviors, and cigarette appeal. In this study, we will leverage our combined expertise in tobacco chemistry, epidemiology, and human trials assessing biomarkers and behavioral and subjective measures, to address these key knowledge gaps. In Aim 1, we will use stable isotope-labeled sugars added to a commercial cigarette that is low in sugars and will analyze the dose-dependent formation of correspondingly labeled pyrolysis products in the smoke of this cigarette. to characterize the impact of sugars in the filler of U.S. cigarettes on the relevant chemical profile of cigarette smoke. We will also analyze the impact of sugar content on the levels of nicotine and tobacco-specific nitrosamines (TSNA) in the smoke. In Aim 2, we will analyze sugars in U.S. commercial cigarettes and use PATH biomarker data to investigate the impact of sugar content in cigarette tobacco on toxicant and carcinogen intake in U.S. smokers. In Aim 3, we will investigate the impact of sugar content in cigarette tobacco on cigarette abuse liability and appeal by conducting a laboratory study in which smokers will assess study cigarettes with differing levels of sugars in a laboratory setting. The overall goal of this proposal is to provide the FDA with the scientific basis to determine whether sugars should be added to HPHC list and whether their levels in tobacco products should be regulated.
项目总结

项目成果

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DOROTHY K HATSUKAMI其他文献

DOROTHY K HATSUKAMI的其他文献

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{{ truncateString('DOROTHY K HATSUKAMI', 18)}}的其他基金

Impact of sugars on tobacco product toxicity and abuse liability
糖对烟草产品毒性和滥用倾向的影响
  • 批准号:
    10415960
  • 财政年份:
    2020
  • 资助金额:
    $ 43.74万
  • 项目类别:
Impact of sugars on tobacco product toxicity and abuse liability
糖对烟草产品毒性和滥用倾向的影响
  • 批准号:
    10165683
  • 财政年份:
    2020
  • 资助金额:
    $ 43.74万
  • 项目类别:
Clinical Trial of Watercress in Detoxification of Environmental Toxicants and Carcinogens
西洋菜解毒环境毒物和致癌物的临床试验
  • 批准号:
    10214559
  • 财政年份:
    2018
  • 资助金额:
    $ 43.74万
  • 项目类别:
Clinical Trial of Watercress in Detoxification of Environmental Toxicants and Carcinogens
西洋菜解毒环境毒物和致癌物的临床试验
  • 批准号:
    9755388
  • 财政年份:
    2018
  • 资助金额:
    $ 43.74万
  • 项目类别:
Clinical Trial of Watercress in Detoxification of Environmental Toxicants and Carcinogens
西洋菜解毒环境毒物和致癌物的临床试验
  • 批准号:
    10459454
  • 财政年份:
    2018
  • 资助金额:
    $ 43.74万
  • 项目类别:
Consortium on Methods Evaluating Tobacco (COMET): FilterVentilation and Product Standards
烟草评估方法联盟 (COMET):过滤器通风和产品标准
  • 批准号:
    10246918
  • 财政年份:
    2017
  • 资助金额:
    $ 43.74万
  • 项目类别:
Project 1: Effects of unventilated filters on pattern of cigarette use, toxicant exposure and uptake of alternative nicotine products
项目 1:不通风滤嘴对卷烟使用模式、毒物暴露和替代尼古丁产品吸收的影响
  • 批准号:
    10246919
  • 财政年份:
    2017
  • 资助金额:
    $ 43.74万
  • 项目类别:
Core A: Administrative Core
核心A:行政核心
  • 批准号:
    10246922
  • 财政年份:
    2017
  • 资助金额:
    $ 43.74万
  • 项目类别:
Summer Research Program for Diversity Students in PharmacoNeuroImmunology
药学神经免疫学多元化学生夏季研究计划
  • 批准号:
    10407964
  • 财政年份:
    2016
  • 资助金额:
    $ 43.74万
  • 项目类别:
Models For Tobacco Product Evaluation
烟草产品评估模型
  • 批准号:
    8269398
  • 财政年份:
    2012
  • 资助金额:
    $ 43.74万
  • 项目类别:

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