Impact of sugars on tobacco product toxicity and abuse liability
糖对烟草产品毒性和滥用倾向的影响
基本信息
- 批准号:9980626
- 负责人:
- 金额:$ 43.74万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAldehydesAmericanBehaviorBehavioralBiological MarkersCarcinogensCessation of lifeCharacteristicsChemicalsChemistryCigaretteCigarette SmokerDataDiseaseDoseElectronic cigaretteEpidemiologyFillerFructoseFuransGlucoseGoalsHealthHeatingHumanInflammationIntakeKnowledgeLabelLaboratoriesLaboratory StudyLengthManufacturer NameMeasuresMentholMorbidity - disease rateNicotineNitrosaminesOxidative StressPalatePlantsPopulationProcessPropertyPublic HealthReportingResearchResearch PrioritySensorySmokeSmokerSmokingStable Isotope LabelingSucroseTechniquesTobaccoTobacco IndustryTobacco smokeTobacco useToxic effectUnited States Food and Drug AdministrationWeightbasebehavior measurementcarcinogenicitycigarette smokecigarette smokingdemographicsexperimental studyheated tobacco productsmortalitymultidisciplinarystatisticssugartobacco productstooltoxicanturinaryventilation
项目摘要
PROJECT SUMMARY
Sugars, which are present naturally in some tobacco types and are also added to cigarette tobacco filler as
additives, are not included in the FDA list of harmful and potentially harmful constituents (HPHC). Existing
research data suggests that sugars in tobacco filler may contribute to the harmful properties of cigarettes in
three critical ways: by enhancing smoke palatability and appeal and, as precursors to aldehydes and furans in
the smoke, by increasing smoke toxicity and carcinogenicity and potentially addictiveness. Therefore, sugars
are potentially the most versatile key constituents contributing to the smoking-associated morbidity and
mortality. However, there is lack of robust quantitative data on the relationship between tobacco sugar content
and relevant toxicant yields in U.S. commercial cigarettes, and the associated user exposures, behaviors, and
cigarette appeal. In this study, we will leverage our combined expertise in tobacco chemistry, epidemiology,
and human trials assessing biomarkers and behavioral and subjective measures, to address these key
knowledge gaps. In Aim 1, we will use stable isotope-labeled sugars added to a commercial cigarette that is
low in sugars and will analyze the dose-dependent formation of correspondingly labeled pyrolysis products in
the smoke of this cigarette. to characterize the impact of sugars in the filler of U.S. cigarettes on the relevant
chemical profile of cigarette smoke. We will also analyze the impact of sugar content on the levels of nicotine
and tobacco-specific nitrosamines (TSNA) in the smoke. In Aim 2, we will analyze sugars in U.S. commercial
cigarettes and use PATH biomarker data to investigate the impact of sugar content in cigarette tobacco on
toxicant and carcinogen intake in U.S. smokers. In Aim 3, we will investigate the impact of sugar content in
cigarette tobacco on cigarette abuse liability and appeal by conducting a laboratory study in which smokers will
assess study cigarettes with differing levels of sugars in a laboratory setting. The overall goal of this proposal is
to provide the FDA with the scientific basis to determine whether sugars should be added to HPHC list and
whether their levels in tobacco products should be regulated.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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DOROTHY K HATSUKAMI其他文献
DOROTHY K HATSUKAMI的其他文献
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{{ truncateString('DOROTHY K HATSUKAMI', 18)}}的其他基金
Impact of sugars on tobacco product toxicity and abuse liability
糖对烟草产品毒性和滥用倾向的影响
- 批准号:
10415960 - 财政年份:2020
- 资助金额:
$ 43.74万 - 项目类别:
Impact of sugars on tobacco product toxicity and abuse liability
糖对烟草产品毒性和滥用倾向的影响
- 批准号:
10165683 - 财政年份:2020
- 资助金额:
$ 43.74万 - 项目类别:
Clinical Trial of Watercress in Detoxification of Environmental Toxicants and Carcinogens
西洋菜解毒环境毒物和致癌物的临床试验
- 批准号:
10214559 - 财政年份:2018
- 资助金额:
$ 43.74万 - 项目类别:
Clinical Trial of Watercress in Detoxification of Environmental Toxicants and Carcinogens
西洋菜解毒环境毒物和致癌物的临床试验
- 批准号:
9755388 - 财政年份:2018
- 资助金额:
$ 43.74万 - 项目类别:
Clinical Trial of Watercress in Detoxification of Environmental Toxicants and Carcinogens
西洋菜解毒环境毒物和致癌物的临床试验
- 批准号:
10459454 - 财政年份:2018
- 资助金额:
$ 43.74万 - 项目类别:
Consortium on Methods Evaluating Tobacco (COMET): FilterVentilation and Product Standards
烟草评估方法联盟 (COMET):过滤器通风和产品标准
- 批准号:
10246918 - 财政年份:2017
- 资助金额:
$ 43.74万 - 项目类别:
Project 1: Effects of unventilated filters on pattern of cigarette use, toxicant exposure and uptake of alternative nicotine products
项目 1:不通风滤嘴对卷烟使用模式、毒物暴露和替代尼古丁产品吸收的影响
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10246919 - 财政年份:2017
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$ 43.74万 - 项目类别:
Summer Research Program for Diversity Students in PharmacoNeuroImmunology
药学神经免疫学多元化学生夏季研究计划
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10407964 - 财政年份:2016
- 资助金额:
$ 43.74万 - 项目类别:
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