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Impact of sugars on tobacco product toxicity and abuse liability

糖对烟草产品毒性和滥用倾向的影响

基本信息

批准号：
10165683
负责人：
DOROTHY K HATSUKAMI
金额：
$ 43.14万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2023-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10165683
关键词：
Address Aldehydes American Behavior Behavioral Biological Markers Carcinogens Cessation of life Characteristics Chemicals Chemistry Cigarette Cigarette Smoker Data Disease Dose Electronic cigarette Epidemiology Filler Fructose Furans Glucose Goals Health Heating Human Inflammation Intake Knowledge Label Laboratories Laboratory Study Length Manufacturer Name Measures Menthol Morbidity - disease rate Nicotine Nitrosamines Oxidative Stress Palate Plants Population Process Property Public Health Reporting Research Research Priority Sensory Smoke Smoker Smoking Stable Isotope Labeling Sucrose Techniques Tobacco Tobacco Industry Tobacco smoke Tobacco use Toxic effect United States Food and Drug Administration Weight base behavior measurement carcinogenicity cigarette smoke cigarette smoking demographics experimental study heated tobacco products mortality multidisciplinary statistics sugar tobacco products tool toxicant urinary ventilation

项目摘要

PROJECT SUMMARY Sugars, which are present naturally in some tobacco types and are also added to cigarette tobacco filler as additives, are not included in the FDA list of harmful and potentially harmful constituents (HPHC). Existing research data suggests that sugars in tobacco filler may contribute to the harmful properties of cigarettes in three critical ways: by enhancing smoke palatability and appeal and, as precursors to aldehydes and furans in the smoke, by increasing smoke toxicity and carcinogenicity and potentially addictiveness. Therefore, sugars are potentially the most versatile key constituents contributing to the smoking-associated morbidity and mortality. However, there is lack of robust quantitative data on the relationship between tobacco sugar content and relevant toxicant yields in U.S. commercial cigarettes, and the associated user exposures, behaviors, and cigarette appeal. In this study, we will leverage our combined expertise in tobacco chemistry, epidemiology, and human trials assessing biomarkers and behavioral and subjective measures, to address these key knowledge gaps. In Aim 1, we will use stable isotope-labeled sugars added to a commercial cigarette that is low in sugars and will analyze the dose-dependent formation of correspondingly labeled pyrolysis products in the smoke of this cigarette. to characterize the impact of sugars in the filler of U.S. cigarettes on the relevant chemical profile of cigarette smoke. We will also analyze the impact of sugar content on the levels of nicotine and tobacco-specific nitrosamines (TSNA) in the smoke. In Aim 2, we will analyze sugars in U.S. commercial cigarettes and use PATH biomarker data to investigate the impact of sugar content in cigarette tobacco on toxicant and carcinogen intake in U.S. smokers. In Aim 3, we will investigate the impact of sugar content in cigarette tobacco on cigarette abuse liability and appeal by conducting a laboratory study in which smokers will assess study cigarettes with differing levels of sugars in a laboratory setting. The overall goal of this proposal is to provide the FDA with the scientific basis to determine whether sugars should be added to HPHC list and whether their levels in tobacco products should be regulated.

项目概要糖，天然存在于某些烟草类型中，也作为卷烟烟草填料添加到其中添加剂，不包含在 FDA 有害和潜在有害成分 (HPHC) 清单中。现存的研究数据表明，烟草填料中的糖可能会导致卷烟的有害特性三个关键方法：通过增强烟气的适口性和吸引力，以及作为醛和呋喃的前体烟雾，通过增加烟雾毒性和致癌性以及潜在的成瘾性。因此，糖类可能是导致吸烟相关发病率最通用的关键成分，死亡。然而，缺乏关于烟草糖含量之间关系的可靠定量数据和美国商业卷烟中的相关毒物产量，以及相关的用户暴露、行为和香烟的吸引力。在这项研究中，我们将利用我们在烟草化学、流行病学、以及评估生物标志物以及行为和主观测量的人体试验，以解决这些关键问题知识差距。在目标 1 中，我们将使用添加到商用香烟中的稳定同位素标记的糖，该糖是糖含量低，将分析相应标记的热解产物的剂量依赖性形成这支香烟的烟雾。描述美国卷烟烟嘴中糖分对相关烟气的影响香烟烟雾的化学特征。我们还将分析糖含量对尼古丁水平的影响以及烟雾中烟草特有的亚硝胺（TSNA）。在目标 2 中，我们将分析美国商业食品中的糖分卷烟并使用 PATH 生物标志物数据来研究卷烟烟草中糖含量的影响美国吸烟者有毒物和致癌物的摄入量。在目标 3 中，我们将研究糖含量的影响香烟烟草对香烟滥用的责任和上诉，通过进行一项实验室研究，吸烟者将在实验室环境中评估具有不同糖含量的研究香烟。该提案的总体目标是为FDA确定是否将糖添加到HPHC清单中提供科学依据是否应监管其在烟草制品中的含量。