Integrating genomics and the protein interactome for HPV+ head and neck cancer therapy

整合基因组学和蛋白质相互作用组用于 HPV 头颈癌治疗

基本信息

项目摘要

Project Summary/Abstract There is an emerging epidemic of head and neck cancer caused by human papillomavirus (HPV) among both smokers and nonsmokers. While vaccination of boys and girls prior to genital HPV exposure is likely to reduce HPV+ HNC, the impact of vaccination won’t be realized for decades. In the meantime, HPV+ HNC patients are treated with disfiguring surgeries and combined chemoradiation approaches, which are associated with significant short- and long-term morbidities. Individuals with recurrent/metastatic HPV+ HNC generally succumb to their disease. My research program will apply new approaches in functional genomics and mapping networks of physical interactions among cancer proteins in relevant and unique HPV+ HNC preclinical models to translate cancer dependencies in this malignancy into more effective and less toxic therapies. In this proposal, I build upon our past success in 1) defining key genomic “driver” alterations in HNC; 2) developing novel therapeutic approaches; and 3) translating our discoveries using relevant preclinical models into clinical treatments for HNC patients. My future research program seeks to 1) define the key genetic alterations that mediate HPV+ HNC growth in conjunction with determination of the protein interactome to identify new therapeutic targets; 2) determine the mechanisms of each target and its role in HPV+ HNC; and 3) translate these findings into new treatments for HPV+ HNC. I will begin with the study of targets that have emerged in our research as relevant in HPV+ HNC such as alterations that activate phosphatidylinositol 3- kinase (PI3K) signaling including mutation or amplification of PIK3CA, or PTEN loss, and activation of the EGFR family member HER3. When relevant, I will extend these findings to other HPV+ cancers including cervical and anal cancers as well as HPV- HNC, which remain lethal. With deep expertise in the molecular pathogenesis and care of patients with HNC; experience leading multi-disciplinary teams focused on translational research approaches for this disease and a rich network of basic science and clinical collaborators, I am uniquely positioned to succeed in the 7 year research plan delineated in this proposal.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Jennifer Rubin Grandis其他文献

Retinoic acid normalizes the increased gene transcription rate of TGF–α and EGFR in head and neck cancer cell lines
维甲酸可使头颈癌细胞系中 TGF–α 和 EGFR 基因转录速率增加恢复正常
  • DOI:
    10.1038/nm0296-237
  • 发表时间:
    1996-02-01
  • 期刊:
  • 影响因子:
    50.000
  • 作者:
    Jennifer Rubin Grandis;Qing Zeng;David J. Tweardy
  • 通讯作者:
    David J. Tweardy
Phospholipase C-γ1 in tumor progression
  • DOI:
    10.1023/a:1024088922957
  • 发表时间:
    2003-07-01
  • 期刊:
  • 影响因子:
    3.200
  • 作者:
    Alan Wells;Jennifer Rubin Grandis
  • 通讯作者:
    Jennifer Rubin Grandis

Jennifer Rubin Grandis的其他文献

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{{ truncateString('Jennifer Rubin Grandis', 18)}}的其他基金

Targeting STAT3 to enhance anti-tumor immunity
靶向STAT3增强抗肿瘤免疫力
  • 批准号:
    10405428
  • 财政年份:
    2019
  • 资助金额:
    $ 77万
  • 项目类别:
Targeting STAT3 to enhance anti-tumor immunity
靶向STAT3增强抗肿瘤免疫力
  • 批准号:
    10621927
  • 财政年份:
    2019
  • 资助金额:
    $ 77万
  • 项目类别:
Integrating genomics and the protein interactome for HPV+ head and neck cancer therapy
整合基因组学和蛋白质相互作用组用于 HPV 头颈癌治疗
  • 批准号:
    10664975
  • 财政年份:
    2018
  • 资助金额:
    $ 77万
  • 项目类别:
Integrating genomics and the protein interactome for HPV+ head and neck cancer therapy
整合基因组学和蛋白质相互作用组用于 HPV 头颈癌治疗
  • 批准号:
    9764300
  • 财政年份:
    2018
  • 资助金额:
    $ 77万
  • 项目类别:
Integrating genomics and the protein interactome for HPV+ head and neck cancer therapy
整合基因组学和蛋白质相互作用组用于 HPV 头颈癌治疗
  • 批准号:
    10224700
  • 财政年份:
    2018
  • 资助金额:
    $ 77万
  • 项目类别:
Integrating genomics and the protein interactome for HPV+ head and neck cancer therapy
整合基因组学和蛋白质相互作用组用于 HPV 头颈癌治疗
  • 批准号:
    10456330
  • 财政年份:
    2018
  • 资助金额:
    $ 77万
  • 项目类别:
Clinical and Translational Science Institute
临床与转化科学研究所
  • 批准号:
    9341569
  • 财政年份:
    2016
  • 资助金额:
    $ 77万
  • 项目类别:
Clinical and Translational Science Institute
临床与转化科学研究所
  • 批准号:
    9317561
  • 财政年份:
    2016
  • 资助金额:
    $ 77万
  • 项目类别:
PI3K Pathway Mutations in Head and Neck Cancer
头颈癌中的 PI3K 通路突变
  • 批准号:
    10398070
  • 财政年份:
    2014
  • 资助金额:
    $ 77万
  • 项目类别:
GPCR Signaling in SCCHN: Integration with EGFR
SCCHN 中的 GPCR 信号转导:与 EGFR 整合
  • 批准号:
    8606299
  • 财政年份:
    2014
  • 资助金额:
    $ 77万
  • 项目类别:

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