Reducing cannabis use for sleep among adults using medical cannabis

减少使用医用大麻的成年人用于睡眠的大麻使用

• 批准号: 9982845
• 负责人: J. Todd Arnedt
• 金额: $ 23.4万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9982845
• 关键词: Address; Adult; Appointment; Behavior; Behavioral; Belief; Cannabis; Certification; Chronic Insomnia; Clinic; Cognitive; Cognitive Therapy; Comorbid Insomnia; Data; Data Reporting; Disease remission; District of Columbia; Education; Elements; Evidence based treatment; Exhibits; Frequencies; Future; General Population; Health; Impairment; Individual; Intervention; Interview; Intoxication; Legal; Link; Low income; Measures; Medical; Medical Marijuana; Mental Health; Modality; Motivation; Movement; National Institute of Drug Abuse; Outcome; Participant; Patient Self-Report; Patients; Pattern; Physical Function; Population; Procedures; Protocols documentation; Qualifying; Randomized; Randomized Controlled Trials; Reporting; Research; Science; Self Efficacy; Severities; Sleep; Sleep Disorders; Sleep disturbances; Sleeplessness; Social Functioning; Strategic Planning; Substance Use Disorder; Surveys; Telemedicine; Telephone; Testing; Time; United States; Work; actigraphy; addiction; alcohol use disorder; base; cognitive benefits; cognitive function; comorbidity; efficacy trial; eligible participant; evidence base; health care settings; improved; improved outcome; innovation; marijuana legalization; marijuana use; marijuana use disorder; marijuana user; middle age; novel; primary outcome; randomized trial; recruit; sleep health; sleep quality; sleep-focused interventions; trial comparing

Project Summary/Abstract In recent years, the movement to promote the legalization of medical cannabis has grown in the United States and now 29 States and the District of Columbia have provisions that allow for the use of cannabis for medical reasons. Irrespective of the specific reasons for seeking medical cannabis, adults who have been evaluated for medical cannabis certification report significant sleep-related problems as well as frequent use of cannabis to address their sleep problems. Cannabis use for sleep is a key potential target for interventions given that prior research has found that, among individuals with cannabis use disorders, poor sleep is a barrier to sustained remission from cannabis use. Cognitive Behavioral Therapy (CBT) for insomnia is highly effective in individuals with insomnia comorbid with other health conditions, including substance use disorders; however, existing efficacy trials have not specifically evaluated its benefit in those who use cannabis for insomnia. The impact of CBT for insomnia on either sleep or cannabis use in medical cannabis users is, therefore, unknown. The objectives of this project are to adapt and tailor a telephone-delivered CBT for insomnia for adults who use medical cannabis (CBTi-CB) and to evaluate the acceptability and feasibility of this intervention. Qualitative and quantitative data will be collected to refine an existing CBTi-CB protocol and conduct a pilot test of the modified intervention in adults who use medical cannabis. Adults seeking certification for medical cannabis will be approached while waiting for their appointment and screened for insomnia as well as cannabis use for sleep. After initial qualitative interviews and beta testing, eligible participants (N = 40) will be randomized to CBTi-CB or Sleep Education Control (SE) condition, delivered over the telephone. Participants will provide self- report data on sleep/insomnia, functioning and cannabis use and objective data on sleep quality will be measured by actigraphy. The study will evaluate changes in self-reported and objectively measured sleep, functioning and frequency/quantity of cannabis use during treatment and over the course of 18-weeks post- baseline. Completion of the study aims will provide all of the elements required for a future fully-powered randomized trial of the longer-term efficacy of CBTi-CB among those with medical cannabis. This line of research would be the first to evaluate a highly effective sleep-focused intervention and determine the effects on sleep-related and non-sleep-related cannabis use in a non-treatment seeking population.

项目摘要/摘要 近年来，促进医用大麻合法化的运动在美国发展了 现在有29个州和哥伦比亚特区有规定可以使用大麻进行医疗 原因。不论寻求医用大麻的具体原因如何，对成年人进行了评估 医用大麻认证报告了与睡眠有关的重大问题，并经常使用大麻 解决他们的睡眠问题。鉴于先前 研究发现，在大麻使用障碍的人中，睡眠不佳是持续的障碍 大麻使用中的缓解。失眠的认知行为疗法（CBT）在个体中非常有效 与其他健康状况（包括药物使用障碍）的失眠症合并；但是，存在 功效试验尚未在使用大麻进行失眠的人中特别评估其利益。的影响 因此，用于在医用大麻使用者中使用睡眠或大麻使用的失眠的CBT是未知的。这 该项目的目的是适应和量身定制通过电话的CBT，用于用于使用的成年人的失眠症 医用大麻（CBTI-CB），并评估这种干预的可接受性和可行性。定性 并将收集定量数据以完善现有的CBTI-CB协议，并对 对使用医用大麻的成年人进行了修改。寻求医用大麻认证的成年人将 在等待约会并筛选失眠以及大麻使用时，可以接触 睡觉。在最初的定性访谈和Beta测试之后，合格的参与者（n = 40）将被随机分为 通过电话交付的CBTI-CB或睡眠教育控制（SE）条件。参与者将提供自我 报告有关睡眠/失眠，功能和大麻使用以及有关睡眠质量的客观数据的数据 通过艺术学衡量。该研究将评估自我报告和客观测量睡眠的变化， 在治疗过程中和在18周的过程中的功能和频率/数量 基线。研究目的的完成将为未来全力以赴的所有要素提供所有要素 CBTI-CB长期疗效的随机试验中的医用大麻。这条线 研究将是第一个评估高效以睡眠干预措施并确定影响的人 在与睡眠有关的和无睡眠有关的大麻中，在未治疗的人群中使用。