Sample Repository for Human Genetic Research

NHGRI人类遗传研究样本库 FOA PAR-14-191 项目摘要 NHGRI人类遗传研究样本库提供了一个可访问的， 负担得起的，集中的人类遗传学材料资源 在广泛的人群中进行研究，用于生物医学研究。主办 2006年，NHGRI在Coriell医学研究所成立， NHGRI资料库中的样本来自国际人类基因组单体型图项目， 基因组计划、人类微生物组计划和用于分析 结构变化。NHGRI知识库的目标是激励和促进 通过建立和维护一个高质量的， 未污染的、充分表征的和记录良好的细胞系和DNA，并分发 将这些资源提供给世界各地的科学家和临床医生。NHGRI存储库示例是 为从事广泛研究的研究人员提供独特而宝贵的资源， 了解人类基因组的结构和功能，包括对人类基因组的研究。 遗传变异及其与疾病易感性和其他共同性状的关系。 这些标准化资源是充分利用 人类基因组计划，以了解疾病的遗传起源。NHGRI 知识库的活动遵循高质量标准，包括：（1）建立， 细胞系的表征、维持和分布，（2）制备、储存和 来自细胞系的DNA的分配，（3）细胞团和DNA的定制制备物的分配 按照科学界的要求，（4）维持一个安全和全面的 数据库和在线目录，以及（5）公布NHGRI库的集合。的目标 与NHGRI的使命一致，以支持开发 通过基因组的传播加速基因组研究的资源和技术 向公众和卫生专业人员提供信息。

NHGRI Sample Repository for Human Genetic Research FOA PAR-14-191 PROJECT SUMMARY The NHGRI Sample Repository for Human Genetic Research provides an accessible, affordable, and centralized resource of well-characterized materials for human genetics research in a wide range of human populations for use in biomedical research. Sponsored by the NHGRI and established at the Coriell Institute for Medical Research in 2006, the collections in the NHGRI Repository include samples from the International HapMap Project, 1000 Genomes Project, Human Microbiome Project, and the Fosmid Library Collection for Analysis of Structural Variation. The objectives of the NHGRI Repository are to stimulate and facilitate the study of human genetic variation by establishing and maintaining a repository of high-quality, uncontaminated, well-characterized, and well-documented cell lines and DNA, and to distribute these resources to scientists and clinicians around the world. NHGRI Repository samples are a unique and valuable resource for investigators working on a broad range of studies aimed at understanding the structure and function of the human genome, including studies of human genetic variation and their association with disease susceptibility and other common traits. These standardized resources are critical elements in the efforts to take full advantage of the Human Genome Project for understanding the genetic origin of disease. The NHGRI Repository's activities are governed by high standards of quality and include: (1) establishment, characterization, maintenance, and distribution of cell lines, (2) preparation, storage, and distribution of DNA from cell lines, (3) distribution of custom preparations of cell pellets and DNA as requested by the scientific community, (4) maintenance of a secure and comprehensive database and online catalog, and (5) publicizing the NHGRI Repository's collection. The goals of the Repository are consistent with the mission of the NHGRI to support development of resources and technology that accelerate genomic research through dissemination of genome information to the public and health professionals.