NHGRI Sample Repository for Human Genetic Research

NHGRI 人类基因研究样本库

• 批准号: 10269976
• 负责人: LAURA SCHEINFELDT
• 金额: $ 94.97万
• 依托单位: CORIELL INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-08 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10269976
• 关键词: Adherence; Biocompatible Materials; Biological; Biomedical Research; Catalogs; Cell Line; Cells; Collection; Communities; Consent; Country; Custom; DNA; Data; Databases; Development; Diagnosis; Educational process of instructing; Ensure; Equipment and supply inventories; Event; Genetic; Genetic Diseases; Genetic Research; Genetic Variation; Genome; Genomics; Goals; Growth; Human; Human Genetics; Infrastructure; Institutes; International; Maintenance; Medical Research; Mission; Molecular Weight; National Human Genome Research Institute; Population; Preparation; Prevention; RNA; Recording of previous events; Reporting; Reproducibility; Research; Research Activity; Research Personnel; Resource Development; Resources; Sampling; Secure; Surveys; Suspensions; Technology; Third Generation Sequencing; Trust; United States National Institutes of Health; Work; biobank; experience; genomic variation; human disease; human pangenome; improved; induced pluripotent stem cell; innovation; member; operation; outreach; repository; research study; symposium; web site

PROJECT SUMMARY Sponsored by the NHGRI and established at the Coriell Institute in 2006, the NHGRI Sample Repository for Human Genetic Research provides a publically accessible, and centralized resource of well-characterized biospecimens from a wide range of global human populations, including the 1000 Genomes Project collection, for use in biomedical research. The objectives of the NHGRI Repository are to stimulate and facilitate the study of human genetic and genomic variation by establishing, maintaining, and distributing a repository of high-quality, renewable, reproducible, well-characterized, and broadly consented cell lines and DNA. The NHGRI Repository is a global resource that has been used by thousands of investigators to support countless research studies. Since its inception, over two hundred thousand cell lines, DNA and RNA samples have been distributed to researchers in 50 countries around the world, and thousands of scientific articles have resulted from studies using these samples and associated data. Proposed NHGRI Repository activities include: (1) maintaining inventory and distributing NHGRI Repository cell lines and DNA samples for the existing repository collection, (2) distributing custom preparations and lots of DNA, High Molecular Weight (HMW) DNA, RNA, cell pellets, and custom plates and panels as requested by the scientific community, (3) expanding the repository to include biospecimen submissions from the Human Pangenome Reference Consortium and creating a new panel of induced pluripotent stem cells that will encompass a wide range of genomic variation to meet the growing needs of the research community, and (4) maintaining a comprehensive and secure database and public online catalog for NHGRI Repository activities, and engaging the scientific community and public at large through scientific presentations, conferences, educational events, and community reports. With over 50 years of NIH-sponsored biobanking expertise, Coriell is uniquely qualified to achieve these aims and strategically expand the operations and offerings of the NHGRI Repository. The goals of the NHGRI Repository are consistent with the NHGRI’s mission to support development of resources and technology that accelerate genomic research. Coriell is a trusted NIH partner and has the infrastructure, expertise, and track-record to ensure the successful operations, maintenance and growth of this important and unique genomic resource.

项目概要 NHGRI 样本存储库由 NHGRI 赞助并于 2006 年在 Coriell 研究所建立 人类基因研究提供了一个可公开访问的、集中的、特征明确的资源。 来自全球广泛人群的生物样本，包括千人基因组计划收集的生物样本， 用于生物医学研究。 NHGRI 存储库的目标是刺激和促进研究 通过建立、维护和分发高质量、 可再生、可重复、特征明确且得到广泛认可的细胞系和 DNA。 NHGRI 存储库 是一种全球资源，已被数千名研究人员用来支持无数的研究。 自成立以来，已有超过二十万个细胞系、DNA 和 RNA 样本分发给 全球50个国家的研究人员，研究成果数千篇科学文章 使用这些样本和相关数据。拟议的 NHGRI 存储库活动包括：(1) 维护 为现有的储存库收集库存和分发 NHGRI 储存库细胞系和 DNA 样本， (2) 分发定制制剂和大量 DNA、高分子量 (HMW) DNA、RNA、细胞沉淀和 根据科学界的要求定制板和面板，(3) 扩展存储库以包括 人类泛基因组参考联盟提交的生物样本并创建了一个新的小组 诱导多能干细胞将包含广泛的基因组变异以满足不断增长的需求 研究界的成员，以及 (4) 维护全面且安全的数据库和公共在线目录 NHGRI 知识库活动，并通过科学界和广大公众参与 演示、会议、教育活动和社区报告。 NIH 资助已有 50 多年历史 凭借生物样本库的专业知识，Coriell 具有独特的资格来实现这些目标并战略性地扩展业务 以及 NHGRI 存储库的产品。 NHGRI 存储库的目标与 NHGRI 的目标一致 使命是支持加速基因组研究的资源和技术的开发。科里尔是一个 值得信赖的 NIH 合作伙伴，拥有确保成功运营的基础设施、专业知识和跟踪记录， 这一重要而独特的基因组资源的维护和发展。