Model-based cerebrovascular markers extracted from hemodynamic data for diagnosing MCI or AD and predicting disease progression.
从血流动力学数据中提取的基于模型的脑血管标志物,用于诊断 MCI 或 AD 并预测疾病进展。
基本信息
- 批准号:10187475
- 负责人:
- 金额:$ 229.96万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AdvocateAgeAlzheimer&aposs DiseaseAlzheimer&aposs disease patientAlzheimer’s disease biomarkerApolipoprotein EAtrophicBiological MarkersBlood Flow VelocityBlood PressureBrainCarbon DioxideCerebral small vessel diseaseCerebrovascular CirculationCerebrumClassificationCohort StudiesDataDatabasesDeteriorationDiagnosisDisease ProgressionEducationElderlyEvaluationGenderGenotypeGoalsImpaired cognitionMagnetic Resonance ImagingMeasuresMethodologyModelingMonitorNear-Infrared SpectroscopyNeurocognitiveNeuropsychological TestsOutputPathologicPatientsPerfusionPersonsPlasmaPositron-Emission TomographyPublishingRegulationRetrospective StudiesSiteStructureVasomotorWhite Matter Hyperintensityamnestic mild cognitive impairmentbasecerebral hemodynamicscerebrovascularcohortfollow-uphemodynamicsimprovedmild cognitive impairmentnovelportabilitypredictive modelingprimary care settingresponsescreeningtissue oxygenationwhite matterβ-amyloid burden
项目摘要
"Model-based cerebrovascular markers extracted from hemodynamic data for
non-invasive, portable and inexpensive diagnosis of MCI or mild AD and prediction of
disease progression"
PROJECT SUMMARY
The goal of the proposed multi-PI project is to establish proof of concept for the utility of a new
class of cerebrovascular markers that may aid in the improved diagnosis and prediction of
disease progression in Mild Cognitive Impairment (MCI) and mild Alzheimer's disease (AD).
The means for obtaining these markers are non-invasive, inexpensive and portable, so that they
can be used for screening in a primary-care setting. The scientific rationale for this new class of
cerebrovascular markers is provided by the recent promising results of our group and the
mounting evidence of a strong correlation between MCI/AD and cerebrovascular dysregulation.
A recently published retrospective study on a large cohort of 1,171 subjects from the ADNI
database utilized multi-factorial data-driven analysis to assess the relation between MCI/AD
disease progression and commonly used biomarkers (obtained from MRI/PET and plasma/CSF)
and concluded that cerebrovascular dysregulation is the earliest and strongest pathologic
factor associated with AD progression, corroborating the hypothesis of cerebrovascular
dysregulation.
Quantification of cerebrovascular dysregulation in that large-cohort study was achieved through
analysis of ASL-MRI data of cerebral perfusion. We propose instead to explore a novel
integrative dynamic modeling approach that analyzes the cerebral hemodynamics of
persons with no cognitive impairment and MCI/AD patients with a methodology that yields input-
output predictive models of the dynamic relationships between changes in beat-to-beat cerebral
blood flow velocity (via Transcranial Doppler) or cerebral tissue oxygenation (via Near Infrared
Spectroscopy) in response to changes in arterial blood pressure and end-tidal CO2 data. The
obtained data-based models are subsequently used to compute markers of the dynamics of
cerebrovascular regulation. Initial results of the advocated approach have achieved
statistically significant delineation between 46 MCI patients and 20 age-matched controls on the
basis of a model-based marker of dynamic vasomotor reactivity (DVR). Evaluation of the
DVR marker against established MRI-based and PET-based biomarkers, as well as
neuropsychological test data, from the larger cohort of the proposed project offers the promise
of portable, non-invasive, inexpensive and sensitive means for detecting cerebrovascular
dysregulation at the early stages of MCI or mild AD, and monitoring disease progression.
Important co-variates of this study include age, gender, education, ApoE genotype, site and
amyloid burden.
“从血液动力学数据中提取的基于模型的脑血管标记物,
MCI或轻度AD的非侵入性、便携式和廉价的诊断以及
疾病进展”
项目摘要
建议的多PI项目的目标是建立一个新的实用程序的概念证明
这类脑血管标志物可能有助于改善诊断和预测
轻度认知障碍(MCI)和轻度阿尔茨海默病(AD)的疾病进展。
用于获得这些标记的手段是非侵入性的、廉价的和便携的,使得它们
可用于初级保健环境中的筛查。这种新的分类的科学原理
脑血管标志物是由我们小组最近的有希望的结果提供的,
越来越多的证据表明MCI/AD和脑血管失调之间存在强相关性。
最近发表的一项对来自ADNI的1,171名受试者的大型队列的回顾性研究
数据库利用多因素数据驱动分析来评估MCI/AD之间的关系
疾病进展和常用生物标志物(从MRI/PET和血浆/CSF中获得)
并得出结论,脑血管失调是最早和最强烈的病理性
与AD进展相关的因素,证实了脑血管疾病的假设
失调
在这项大队列研究中,通过以下方法实现了脑血管失调的量化:
脑灌注的ASL-MRI数据分析。我们建议写一部小说
综合动态建模方法,分析脑血流动力学的
没有认知障碍的人和MCI/AD患者使用产生输入的方法-
输出预测模型的动态关系之间的变化,心跳,心跳脑
血流速度(经颅多普勒)或脑组织氧合(近红外
光谱),以响应动脉血压和呼气末CO2数据的变化。的
所获得的基于数据的模型随后用于计算
脑血管调节所倡导的方法已取得初步成果
46名MCI患者和20名年龄匹配的对照者之间的统计学显著性描绘,
基于模型的动态血管反应性(DVR)标志物的基础。评价
DVR标志物与已建立的基于MRI和基于PET的生物标志物,以及
神经心理学测试数据,从更大的队列的拟议项目提供了承诺
便携式,非侵入性,廉价和灵敏的手段来检测脑血管
在MCI或轻度AD的早期阶段的失调,并监测疾病进展。
本研究的重要协变量包括年龄、性别、教育、ApoE基因型、研究中心和
淀粉样蛋白负荷。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Sandra A Billinger其他文献
Sandra A Billinger的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Sandra A Billinger', 18)}}的其他基金
Revision Supplement: Model-based cerebrovascular markers extracted from hemodynamic data for diagnosing MCI or AD and predicting disease progression
修订补充:从血流动力学数据中提取的基于模型的脑血管标志物,用于诊断 MCI 或 AD 并预测疾病进展
- 批准号:
10242469 - 财政年份:2018
- 资助金额:
$ 229.96万 - 项目类别:
Model-based cerebrovascular markers extracted from hemodynamic data for diagnosing MCI or AD and predicting disease progression.
从血流动力学数据中提取的基于模型的脑血管标志物,用于诊断 MCI 或 AD 并预测疾病进展。
- 批准号:
10404604 - 财政年份:2018
- 资助金额:
$ 229.96万 - 项目类别:
Model-based cerebrovascular markers extracted from hemodynamic data for diagnosing MCI or AD and predicting disease progression.
从血流动力学数据中提取的基于模型的脑血管标志物,用于诊断 MCI 或 AD 并预测疾病进展。
- 批准号:
9764219 - 财政年份:2018
- 资助金额:
$ 229.96万 - 项目类别:
Examining Vascular Regulation Following Acute Stroke
检查急性中风后的血管调节
- 批准号:
8460137 - 财政年份:2011
- 资助金额:
$ 229.96万 - 项目类别:
Examining Vascular Regulation Following Acute Stroke
检查急性中风后的血管调节
- 批准号:
8676494 - 财政年份:2011
- 资助金额:
$ 229.96万 - 项目类别:
Examining Vascular Regulation Following Acute Stroke
检查急性中风后的血管调节
- 批准号:
8188791 - 财政年份:2011
- 资助金额:
$ 229.96万 - 项目类别:
Examining Vascular Regulation Following Acute Stroke
检查急性中风后的血管调节
- 批准号:
8848408 - 财政年份:2011
- 资助金额:
$ 229.96万 - 项目类别:
Examining Vascular Regulation Following Acute Stroke
检查急性中风后的血管调节
- 批准号:
8310933 - 财政年份:2011
- 资助金额:
$ 229.96万 - 项目类别:
相似国自然基金
靶向递送一氧化碳调控AGE-RAGE级联反应促进糖尿病创面愈合研究
- 批准号:JCZRQN202500010
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
对香豆酸抑制AGE-RAGE-Ang-1通路改善海马血管生成障碍发挥抗阿尔兹海默病作用
- 批准号:2025JJ70209
- 批准年份:2025
- 资助金额:0.0 万元
- 项目类别:省市级项目
AGE-RAGE通路调控慢性胰腺炎纤维化进程的作用及分子机制
- 批准号:
- 批准年份:2024
- 资助金额:0 万元
- 项目类别:面上项目
甜茶抑制AGE-RAGE通路增强突触可塑性改善小鼠抑郁样行为
- 批准号:2023JJ50274
- 批准年份:2023
- 资助金额:0.0 万元
- 项目类别:省市级项目
蒙药额尔敦-乌日勒基础方调控AGE-RAGE信号通路改善术后认知功能障碍研究
- 批准号:
- 批准年份:2022
- 资助金额:33 万元
- 项目类别:地区科学基金项目
补肾健脾祛瘀方调控AGE/RAGE信号通路在再生障碍性贫血骨髓间充质干细胞功能受损的作用与机制研究
- 批准号:
- 批准年份:2022
- 资助金额:52 万元
- 项目类别:面上项目
LncRNA GAS5在2型糖尿病动脉粥样硬化中对AGE-RAGE 信号通路上相关基因的调控作用及机制研究
- 批准号:n/a
- 批准年份:2022
- 资助金额:10.0 万元
- 项目类别:省市级项目
围绕GLP1-Arginine-AGE/RAGE轴构建探针组学方法探索大柴胡汤异病同治的效应机制
- 批准号:81973577
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
AGE/RAGE通路microRNA编码基因多态性与2型糖尿病并发冠心病的关联研究
- 批准号:81602908
- 批准年份:2016
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
高血糖激活滑膜AGE-RAGE-PKC轴致骨关节炎易感的机制研究
- 批准号:81501928
- 批准年份:2015
- 资助金额:18.0 万元
- 项目类别:青年科学基金项目
相似海外基金
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341426 - 财政年份:2024
- 资助金额:
$ 229.96万 - 项目类别:
Continuing Grant
Collaborative Research: Resolving the LGM ventilation age conundrum: New radiocarbon records from high sedimentation rate sites in the deep western Pacific
合作研究:解决LGM通风年龄难题:西太平洋深部高沉降率地点的新放射性碳记录
- 批准号:
2341424 - 财政年份:2024
- 资助金额:
$ 229.96万 - 项目类别:
Continuing Grant
PROTEMO: Emotional Dynamics Of Protective Policies In An Age Of Insecurity
PROTEMO:不安全时代保护政策的情绪动态
- 批准号:
10108433 - 财政年份:2024
- 资助金额:
$ 229.96万 - 项目类别:
EU-Funded
The role of dietary and blood proteins in the prevention and development of major age-related diseases
膳食和血液蛋白在预防和发展主要与年龄相关的疾病中的作用
- 批准号:
MR/X032809/1 - 财政年份:2024
- 资助金额:
$ 229.96万 - 项目类别:
Fellowship
Atomic Anxiety in the New Nuclear Age: How Can Arms Control and Disarmament Reduce the Risk of Nuclear War?
新核时代的原子焦虑:军控与裁军如何降低核战争风险?
- 批准号:
MR/X034690/1 - 财政年份:2024
- 资助金额:
$ 229.96万 - 项目类别:
Fellowship
Walkability and health-related quality of life in Age-Friendly Cities (AFCs) across Japan and the Asia-Pacific
日本和亚太地区老年友好城市 (AFC) 的步行适宜性和与健康相关的生活质量
- 批准号:
24K13490 - 财政年份:2024
- 资助金额:
$ 229.96万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Discovering the (R)Evolution of EurAsian Steppe Metallurgy: Social and environmental impact of the Bronze Age steppes metal-driven economy
发现欧亚草原冶金的(R)演变:青铜时代草原金属驱动型经济的社会和环境影响
- 批准号:
EP/Z00022X/1 - 财政年份:2024
- 资助金额:
$ 229.96万 - 项目类别:
Research Grant
ICF: Neutrophils and cellular senescence: A vicious circle promoting age-related disease.
ICF:中性粒细胞和细胞衰老:促进与年龄相关疾病的恶性循环。
- 批准号:
MR/Y003365/1 - 财政年份:2024
- 资助金额:
$ 229.96万 - 项目类别:
Research Grant
Doctoral Dissertation Research: Effects of age of acquisition in emerging sign languages
博士论文研究:新兴手语习得年龄的影响
- 批准号:
2335955 - 财政年份:2024
- 资助金额:
$ 229.96万 - 项目类别:
Standard Grant
Shaping Competition in the Digital Age (SCiDA) - Principles, tools and institutions of digital regulation in the UK, Germany and the EU
塑造数字时代的竞争 (SCiDA) - 英国、德国和欧盟的数字监管原则、工具和机构
- 批准号:
AH/Y007549/1 - 财政年份:2024
- 资助金额:
$ 229.96万 - 项目类别:
Research Grant