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Developmental effects of early hearing loss on auditory information processing

早期听力损失对听觉信息处理的发育影响

基本信息

批准号：
10188487
负责人：
Achim Klug
金额：
$ 52.36万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-12-09 至 2023-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10188487
关键词：
Ablation Acoustics Adult Aging Attention deficit hyperactivity disorder Audiology Auditory Auditory Brainstem Responses Auditory system Behavior assessment Behavioral Bilateral Binaural Biological Markers Brain Stem Calibration Cell Nucleus Central Auditory Processing Disorder Child Clinic Clinical Cochlear Implants Cognitive Comparative Study Complex Conductive hearing loss Continuous Ambulatory Peritoneal Dialysis Detection Development Devices Diagnostic Discrimination Early Intervention Elderly Electrodes Electrophysiology (science)Environment Equipment Etiology Frequencies Head Hearing Hearing Aids Human Impairment Individual Language Development Language Disorders Lead Learning Disabilities Lesion Life Measurement Measures Medial Methods Modeling Multiple Sclerosis Nature Neurodegenerative Disorders Neurons Newborn Infant Normal Range Pathway interactions Patients Perception Performance Performance at work Physiological Population Process Production Protocols documentation Psychophysics Quality of life Reporting Research Residual state Restaurants Risk Factors Sensory Social Interaction Sound Localization Source Speech Stimulus Stream Sum Surface Testing Time Translating Traumatic Brain Injury Variant Workplace analytical tool auditory pathway auditory processing autism spectrum disorder base binaural hearing childhood hearing loss clinical Diagnosis developmental disease experience experimental study fitness hearing impairment hearing restoration hearing screening human subject improved in vivo infancy information processing insight language perception lateral superior olive medial superior olive neurophysiology optogenetics potential biomarker predictive marker rehabilitation strategy relating to nervous system symptom cluster tool trapezoid body

项目摘要

PROJECT SUMMARY Binaural hearing allows accurate and precise localization of sounds, and also confers advantages in complex environments such as workplaces, classrooms, restaurants, etc. where competing speech streams, noisy backgrounds, and reverberation abound. Unfortunately, an increasing population, spanning infancy through elderly and of diverse etiology, experiences severe difficulty in such environments despite having normal audiometric thresholds. Such difficulties are a hallmark of Central Auditory Processing Disorder, CAPD, which refers to difficulties in processing acoustic information in the central auditory system as demonstrated by poor hearing performance, often specifically in binaural hearing tasks. CAPD-like challenges can emerge as a result of temporary conductive hearing loss, aging, traumatic brain injury, autism, neurodegenerative diseases (multiple sclerosis) and use of bilateral clinical devices (hearing aids, cochlear implants). The consequences of CAPD can be severe; in children, CAPD impacts speech and language learning and academic performance and in adults, quality of life, job performance, fitness for duty, social interactions, etc. Regardless of etiology, a major limitation in CAPD is that clinical diagnosis is based on a cluster of symptoms, many of which overlap with other developmental disorders such as attention deficit hyperactivity disorder, learning disabilities and language deficits. Moreover, behavioral assessments of auditory processing, particularly in children and elderly, have poor reliability with scores often reflecting higher-level cognitive or analytical processes rather than basic auditory sensory processing. Thus, early intervention and implementation of rehabilitation strategies in CAPD patients is precluded. A potential way to surmount this barrier is to use non-invasive electrophysiological measures. Auditory brainstem responses (ABRs) are used worldwide for newborn and adult hearing screening. Because different ABR waves broadly represent activity within different parts of the auditory pathway, it is possible to assess the functional state of distinct stages of the pathway using appropriate stimuli. Binaural stages can be assessed using the binaural interaction component (BIC) of the ABR. The BIC is the residual ABR obtained after subtracting the sum of monaurally- from binaurally-evoked ABRs. Prior research has identified the BIC as a potential biomarker for binaural ability. As the BIC can be measured using equipment and methods already available in most audiology clinics, its development as diagnostic tool could have immediate and widespread clinical value. However, while comparative studies have reported robust BIC in a variety of model species, reports of human BIC are perplexingly variable and unreliable. The proposed research comprises three Aims to establish a comprehensive understanding of the BIC, including 1) identification of its brainstem circuit origin, 2) identification of sources of variability across mammalian species including humans, 3) identification of best practices in human BIC measurement, and assessment of the BIC as a biomarker for predicting meaningful aspects of human binaural perception.

项目摘要双耳听力可以准确、精确地定位声音，并且还具有复杂的优势例如工作场所、教室、餐馆等环境，其中竞争语音流、噪声背景和回响比比皆是。不幸的是，人口不断增加，跨越婴儿期到老年人和各种病因，在这种环境中经历严重的困难，尽管有正常的听力阈值这种困难是中央听觉处理障碍（CAPD）的标志，在中枢听觉系统中处理声学信息的困难，听力表现，通常特别是在双耳听力任务中。因此，可能会出现类似CAPD的挑战暂时性传导性听力损失、衰老、创伤性脑损伤、自闭症、神经退行性疾病（多发性硬化症）和使用双侧临床设备（助听器、人工耳蜗）。的后果 CAPD可能很严重;在儿童中，CAPD会影响言语和语言学习以及学习成绩在成年人中，生活质量，工作表现，责任适应性，社会交往等。 CAPD的主要局限性是临床诊断是基于一组症状，其中许多症状重叠与其他发育障碍，如注意力缺陷多动障碍，学习障碍，语言缺陷此外，听觉处理的行为评估，特别是在儿童和老年人，可靠性差，分数往往反映更高层次的认知或分析过程，比基本的听觉感官处理更重要。因此，早期干预和实施康复战略在CAPD患者中，克服这一障碍的一种潜在方法是使用非侵入性电生理测量。听觉脑干反应（ABR）在世界范围内用于新生儿和成人听力筛查因为不同的ABR波广泛地代表了不同部位的活动，听觉通路，有可能评估的功能状态的不同阶段的途径，使用适当的刺激。双耳阶段可以使用本发明的双耳交互组件（BIC）来评估。 ABR。BIC是从双耳诱发的听觉诱发电位中减去单耳诱发电位和之后获得的残余ABR。听觉诱发电位。先前的研究已经将BIC确定为双耳能力的潜在生物标志物。由于BIC可以使用大多数听力学诊所已有的设备和方法进行测量，其发展作为诊断工具可能具有直接和广泛的临床价值。然而，尽管比较研究尽管在各种模型物种中报告了稳健的BIC，但人类BIC的报告令人困惑地可变，不可靠拟议的研究包括三个目的，以建立一个全面的了解， BIC，包括1）识别其脑干回路起源，2）识别包括人类在内的哺乳动物物种，3）确定人类BIC测量的最佳实践，以及评估BIC作为预测人类双耳感知的有意义方面的生物标志物。