Developmental effects of early hearing loss on auditory information processing

早期听力损失对听觉信息处理的发育影响

• 批准号: 10188487
• 负责人: Achim Klug
• 金额: $ 52.36万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-12-09 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10188487
• 关键词: Ablation; Acoustics; Adult; Aging; Attention deficit hyperactivity disorder; Audiology; Auditory; Auditory Brainstem Responses; Auditory system; Behavior assessment; Behavioral; Bilateral; Binaural; Biological Markers; Brain Stem; Calibration; Cell Nucleus; Central Auditory Processing Disorder; Child; Clinic; Clinical; Cochlear Implants; Cognitive; Comparative Study; Complex; Conductive hearing loss; Continuous Ambulatory Peritoneal Dialysis; Detection; Development; Devices; Diagnostic; Discrimination; Early Intervention; Elderly; Electrodes; Electrophysiology (science); Environment; Equipment; Etiology; Frequencies; Head; Hearing; Hearing Aids; Human; Impairment; Individual; Language Development; Language Disorders; Lead; Learning Disabilities; Lesion; Life; Measurement; Measures; Medial; Methods; Modeling; Multiple Sclerosis; Nature; Neurodegenerative Disorders; Neurons; Newborn Infant; Normal Range; Pathway interactions; Patients; Perception; Performance; Performance at work; Physiological; Population; Process; Production; Protocols documentation; Psychophysics; Quality of life; Reporting; Research; Residual state; Restaurants; Risk Factors; Sensory; Social Interaction; Sound Localization; Source; Speech; Stimulus; Stream; Sum; Surface; Testing; Time; Translating; Traumatic Brain Injury; Variant; Workplace; analytical tool; auditory pathway; auditory processing; autism spectrum disorder; base; binaural hearing; childhood hearing loss; clinical Diagnosis; developmental disease; experience; experimental study; fitness; hearing impairment; hearing restoration; hearing screening; human subject; improved; in vivo; infancy; information processing; insight; language perception; lateral superior olive; medial superior olive; neurophysiology; optogenetics; potential biomarker; predictive marker; rehabilitation strategy; relating to nervous system; symptom cluster; tool; trapezoid body

PROJECT SUMMARY Binaural hearing allows accurate and precise localization of sounds, and also confers advantages in complex environments such as workplaces, classrooms, restaurants, etc. where competing speech streams, noisy backgrounds, and reverberation abound. Unfortunately, an increasing population, spanning infancy through elderly and of diverse etiology, experiences severe difficulty in such environments despite having normal audiometric thresholds. Such difficulties are a hallmark of Central Auditory Processing Disorder, CAPD, which refers to difficulties in processing acoustic information in the central auditory system as demonstrated by poor hearing performance, often specifically in binaural hearing tasks. CAPD-like challenges can emerge as a result of temporary conductive hearing loss, aging, traumatic brain injury, autism, neurodegenerative diseases (multiple sclerosis) and use of bilateral clinical devices (hearing aids, cochlear implants). The consequences of CAPD can be severe; in children, CAPD impacts speech and language learning and academic performance and in adults, quality of life, job performance, fitness for duty, social interactions, etc. Regardless of etiology, a major limitation in CAPD is that clinical diagnosis is based on a cluster of symptoms, many of which overlap with other developmental disorders such as attention deficit hyperactivity disorder, learning disabilities and language deficits. Moreover, behavioral assessments of auditory processing, particularly in children and elderly, have poor reliability with scores often reflecting higher-level cognitive or analytical processes rather than basic auditory sensory processing. Thus, early intervention and implementation of rehabilitation strategies in CAPD patients is precluded. A potential way to surmount this barrier is to use non-invasive electrophysiological measures. Auditory brainstem responses (ABRs) are used worldwide for newborn and adult hearing screening. Because different ABR waves broadly represent activity within different parts of the auditory pathway, it is possible to assess the functional state of distinct stages of the pathway using appropriate stimuli. Binaural stages can be assessed using the binaural interaction component (BIC) of the ABR. The BIC is the residual ABR obtained after subtracting the sum of monaurally- from binaurally-evoked ABRs. Prior research has identified the BIC as a potential biomarker for binaural ability. As the BIC can be measured using equipment and methods already available in most audiology clinics, its development as diagnostic tool could have immediate and widespread clinical value. However, while comparative studies have reported robust BIC in a variety of model species, reports of human BIC are perplexingly variable and unreliable. The proposed research comprises three Aims to establish a comprehensive understanding of the BIC, including 1) identification of its brainstem circuit origin, 2) identification of sources of variability across mammalian species including humans, 3) identification of best practices in human BIC measurement, and assessment of the BIC as a biomarker for predicting meaningful aspects of human binaural perception.

项目概要 双耳听力可以准确、精确地定位声音，并且在复杂的情况下也具有优势 工作场所、教室、餐馆等存在竞争性语音流、嘈杂的环境 背景和混响比比皆是。不幸的是，人口不断增加，从婴儿期到 老年人和具有不同病因的人，尽管具有正常的能力，但在这种环境中会遇到严重的困难 听力阈值。这些困难是中枢听觉处理障碍 (CAPD) 的一个标志， 指中枢听觉系统处理声音信息的困难，表现为表现不佳 听力表现，通常特别是在双耳听力任务中。结果可能会出现类似 CAPD 的挑战 暂时性传导性听力损失、衰老、脑外伤、自闭症、神经退行性疾病 （多发性硬化症）和使用双侧临床设备（助听器、人工耳蜗）。的后果 CAPD 可能很严重；对于儿童来说，CAPD 会影响言语和语言学习以及学业成绩 对于成年人来说，生活质量、工作表现、职责适应性、社交互动等。无论病因如何， CAPD 的主要局限性是临床诊断基于一系列症状，其中许多症状是重叠的 患有其他发育障碍，例如注意力缺陷多动障碍、学习障碍和 语言缺陷。此外，听觉处理的行为评估，特别是儿童和 老年人的可靠性较差，分数通常反映更高水平的认知或分析过程，而不是 比基本的听觉感觉处理。因此，早期干预和实施康复策略 CAPD 患者中被排除。克服这一障碍的一个潜在方法是使用非侵入性技术 电生理措施。听觉脑干反应 (ABR) 在全球范围内用于新生儿和 成人听力筛查。因为不同的 ABR 波广泛代表了不同部位的活动 听觉通路，可以使用以下方法评估该通路不同阶段的功能状态 适当的刺激。双耳阶段可以使用双耳交互组件 (BIC) 进行评估 ABR。 BIC 是从双耳诱发的单耳诱发的总和中减去单耳诱发的 ABR 后得到的剩余 ABR。 ABR。先前的研究已将 BIC 确定为双耳能力的潜在生物标志物。由于 BIC 可以是 使用大多数听力学诊所已有的设备和方法进行测量，其发展为 诊断工具可能具有直接且广泛的临床价值。然而，虽然比较研究已 报道称，在多种模型物种中，BIC 均表现强劲，但人类 BIC 的报道却存在着令人困惑的变化， 不可靠。拟议的研究包括三个目标，以全面了解 BIC，包括 1) 识别其脑干回路起源，2) 识别跨区域变异来源 包括人类在内的哺乳动物物种，3) 确定人类 BIC 测量的最佳实践，以及 评估 BIC 作为预测人类双耳感知有意义方面的生物标志物。

项目成果

Normative Study of the Binaural Interaction Component of the Human Auditory Brainstem Response as a Function of Interaural Time Differences.

• DOI: 10.1097/aud.0000000000000964
• 发表时间: 2021
• 期刊: Ear and hearing
• 影响因子: 3.7
• 作者: Sammeth CA;Greene NT;Brown AD;Tollin DJ
• 通讯作者: Tollin DJ

Physiological models of the lateral superior olive

• DOI: 10.1371/journal.pcbi.1005903
• 发表时间: 2017-12-01
• 期刊: PLOS COMPUTATIONAL BIOLOGY
• 影响因子: 4.3
• 作者: Ashida, Go;Tolling, Daniel J.;Kretzberg, Jutta
• 通讯作者: Kretzberg, Jutta

These are not the neurons you are looking for.

• DOI: 10.7554/elife.39244
• 发表时间: 2018-07-27
• 期刊: eLife
• 影响因子: 7.7
• 作者: Benichoux V;Tollin DJ
• 通讯作者: Tollin DJ

Roles for Coincidence Detection in Coding Amplitude-Modulated Sounds

• DOI: 10.1371/journal.pcbi.1004997
• 发表时间: 2016-06-01
• 期刊: PLOS COMPUTATIONAL BIOLOGY
• 影响因子: 4.3
• 作者: Ashida, Go;Kretzberg, Jutta;Tollin, Daniel J.
• 通讯作者: Tollin, Daniel J.

Diagnosis, Surveillance and Management of Streptococcus equi subspecies zooepidemicus Infections in Chinchillas (Chinchilla lanigera).

龙猫（Chinchilla lanigera）马链球菌亚种兽疫菌感染的诊断、监测和管理。

• DOI: 10.30802/aalas-cm-20-000012
• 发表时间: 2020
• 期刊: Comparative medicine
• 影响因子: 0.8
• 作者: Mitchell,CaraM;Johnson,LindaK;Crim,MarcusJ;Wiedmeyer,CharlesE;Pugazhenthi,Umarani;Tousey,Susan;Tollin,DanielJ;Habenicht,LaurenM;Fink,MichaelK;Fong,DerekL;Leszczynski,JoriK;Manuel,ChristopherA
• 通讯作者: Manuel,ChristopherA