Cell signaling in regeneration and tissue scaling

再生和组织缩放中的细胞信号传导

• 批准号: 10355448
• 负责人: Christian Petersen
• 金额: $ 29.12万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-04-01 至 2024-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10355448
• 关键词: Address; Adult; Amputation; Animals; Anterior; Biological; Biological Assay; Competence; Complex; Cues; Data; Detection; Development; Developmental Process; Disease; Dorsal; Expression Profiling; Failure; Foundations; Goals; Grant; Growth; Head; Histologic; Homeostasis; Injury; Length; Link; Location; Maintenance; Medial; Methods; Molecular; Muscle Cells; Natural regeneration; Nature; Operative Surgical Procedures; Organ; Organism; Pathway interactions; Pattern; Planarians; Positioning Attribute; Process; Publishing; RNA Interference; Regenerative capacity; Regulatory Pathway; Role; Signal Pathway; Signal Transduction; Signaling Molecule; System; Testing; Tissue Differentiation; Tissues; base; experience; experimental study; information model; injury and repair; insight; intercellular communication; novel; novel strategies; organ regeneration; progenitor; regenerative; regenerative growth; regenerative tissue; repaired; restoration; stem cells; tissue regeneration; tissue repair; tissue stem cells; transcriptome sequencing

Project Summary/Abstract Organisms with regenerative abilities have been informative models for uncovering natural mechanisms by which tissue damage activates stem or progenitor cells for injury repair. The timing, location, and extent of injuries are not predetermined, requiring the existence of mechanisms that instruct tissue restoration activities that perfectly counter the effects of damage. A key question to understand this process is how regenerative tissue redefines territories removed by injury, and it is hypothesized this is related to as-yet undiscovered systems that robustly regulate tissue proportionality across large length scales. To begin to address this question, it is essential to define the cell signaling systems that underlie regional identity and proportional growth. While regenerative tissues have been extensively probed for the roles of injury-induced signals and the involvement of stem or progenitor cells, much less is known about the molecular and developmental processes that enable the restoration of form after injury and its maintenance through adult growth. In the aims of this grant, this deficit is addressed by leveraging expertise in the planarian system, which uniquely allows for the study of signaling that regulates re-scaling of tissues through regeneration, to elucidate the regulatory and developmental mechanism that generates and restores tissue proportionality after injury. Uncovering fundamental mechanisms used by organisms to control tissue proportionality will provide foundational insights into understanding diseases of growth misregulation, the nature of proportional growth, and the control of stem cells for tissue regeneration.

项目总结/摘要 具有再生能力的生物体一直是揭示自然机制的信息模型， 该组织损伤激活干细胞或祖细胞用于损伤修复。的时间、地点和程度 损伤不是预先确定的，需要存在指导组织修复活动的机制 可以完美地抵消伤害的影响理解这个过程的一个关键问题是 组织重新定义了因损伤而移除的区域，据推测，这与尚未发现的 这些系统在大的长度尺度上稳健地调节组织比例。为了开始解决这个问题 问题，这是必不可少的，以确定细胞信号系统的基础区域身份和比例 增长虽然再生组织已被广泛探索损伤诱导的信号和再生组织的作用， 由于干细胞或祖细胞的参与，对分子和发育过程的了解要少得多 能够在受伤后恢复形态，并在成年后维持形态。在这一目标中， 补助金，这一赤字是解决利用专业知识在涡虫系统，这是唯一允许 研究通过再生调节组织重新缩放的信号传导，以阐明调节和 在损伤后产生和恢复组织比例的发育机制。揭开 生物体用来控制组织比例的基本机制将提供基本的见解 了解疾病的增长失调，性质的比例增长，和控制茎 组织再生的细胞