Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial

项目摘要 化疗引起的周围神经病变（CIPN）是最有害，最常见， 疼痛和致残的副作用，许多化疗药物，并没有有效的 我们的IIB期两组试验表明，瑜伽治疗与 与常规护理对照相比，CIPN疼痛减少，福尔斯跌倒风险降低。我们的目标是 通过确定有效的治疗方法， 减轻化疗相关毒性。该项目的目标是确定 瑜伽在治疗CIPN疼痛和改善功能方面的功效，以及改善感觉 神经恢复和降低患中度至中度癌症的癌症幸存者的福尔斯风险 严重的CIPN疼痛。我们将进行第三阶段，随机，教育和常规护理- 一项有268名参与者的对照试验：1）确定为期八周的瑜伽的功效 治疗患有中度至重度CIPN疼痛的癌症幸存者的CIPN症状; 2） 评估瑜伽与教育控制和日常护理对提高柔韧性的影响， 降低福尔斯跌倒的风险; 3）评估瑜伽与教育控制和日常锻炼的效果。 对生活质量和感觉纤维功能的护理。

PROJECT SUMMARY Chemotherapy-induced Peripheral Neuropathy (CIPN) is one of the most harmful, common, painful, and disabling side effects of many chemotherapy agents and there is no effective treatment for it. Our pilot phase IIB two-arm trial showed that yoga treatment is associated with reduced CIPN pain and reduced risk of falls compared to usual care control. We aim to increase cancer patients’ function and quality of life by identifying effective treatments to alleviate chemotherapy-related toxicities. The goal of the proposed project is to determine the efficacy of yoga in treating CIPN pain and improving function, as well as to improve sensory nerve recovery and reduce the risk of falls in cancer survivors suffering from moderate to severe CIPN pain. We will conduct a phase III, randomized, education and usual care- controlled trial with 268 participants to: 1) determine the efficacy of an eight-week yoga treatment on CIPN symptoms among cancer survivors with moderate to severe CIPN pain; 2) evaluate the effect of yoga versus education control and usual care on improving flexibility and reducing the risk of falls; and 3) evaluate the effect of yoga versus education control and usual care on quality of life and sensory fiber functioning.