Yoga for Chemotherapy-induced Peripheral Neuropathy Treatment (YCT) Trial

瑜伽治疗化疗引起的周围神经病变 (YCT) 试验

• 批准号: 10372137
• 负责人: Ting Bao
• 金额: $ 73.3万
• 依托单位: SLOAN-KETTERING INST CAN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10372137
• 关键词: Adverse effects; Affect; American Society of Clinical Oncology; Attention; Brief Pain Inventory; Cancer Center; Cancer Patient; Cancer Survivor; Chemotherapy-induced peripheral neuropathy; Clinical; Clinical Trials; Clinical Trials Design; Complication; Controlled Clinical Trials; Data; Education; Equilibrium; Fall prevention; Fatigue; Fiber; Goals; Gynecologic Oncology Group; Headache; Information Systems; Intervention; Longterm Follow-up; Malignant Female Reproductive System Neoplasm; Measurement; Measures; Methods; Mind-Body Intervention; Muscle; National Cancer Institute; Nausea; Numbness; Numeric Rating Scale; Pain; Participant; Patient Care; Patient Outcomes Assessments; Patients; Pharmaceutical Preparations; Pharmacology; Phase; Physical therapy; Pilot Projects; Placebos; Prevention; Quality of life; Questionnaires; Randomized; Randomized Controlled Trials; Recommendation; Recovery; Research; Scientist; Sensory; Severities; Symptoms; Testing; Toxic effect; United States; Yoga; afferent nerve; arm; cancer therapy; care providers; chemotherapy; disability; duloxetine; effective therapy; experience; fall risk; flexibility; functional outcomes; global health; improved; improved functioning; malignant breast neoplasm; meetings; minimally invasive; multidisciplinary; neurotoxic; neurotoxicity; pain reduction; primary endpoint; primary outcome; secondary endpoint; side effect; standard of care; treatment as usual; trial comparing; two-arm trial; usual care arm

PROJECT SUMMARY Chemotherapy-induced Peripheral Neuropathy (CIPN) is one of the most harmful, common, painful, and disabling side effects of many chemotherapy agents and there is no effective treatment for it. Our pilot phase IIB two-arm trial showed that yoga treatment is associated with reduced CIPN pain and reduced risk of falls compared to usual care control. We aim to increase cancer patients’ function and quality of life by identifying effective treatments to alleviate chemotherapy-related toxicities. The goal of the proposed project is to determine the efficacy of yoga in treating CIPN pain and improving function, as well as to improve sensory nerve recovery and reduce the risk of falls in cancer survivors suffering from moderate to severe CIPN pain. We will conduct a phase III, randomized, education and usual care- controlled trial with 268 participants to: 1) determine the efficacy of an eight-week yoga treatment on CIPN symptoms among cancer survivors with moderate to severe CIPN pain; 2) evaluate the effect of yoga versus education control and usual care on improving flexibility and reducing the risk of falls; and 3) evaluate the effect of yoga versus education control and usual care on quality of life and sensory fiber functioning.

项目总结