Acupuncture to Prevent Chemotherapy Dose Reduction

针灸预防化疗剂量减少

基本信息

批准号：
8913622
负责人：
Ting Bao
金额：
$ 18.49万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-02-01 至 2017-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8913622
关键词：
Acupuncture procedure Adjuvant Adjuvant Chemotherapy Adverse effects Cancer Center Cancer Patient Chinese Traditional Medicine Clinical Clinical Research Clinical Trials Colon Carcinoma Colorectal Cancer Controlled Clinical Trials Data Disease Dose Dose-Limiting Effectiveness Foundations Future Goals Health Lead Light Maryland Measures Mediating Multiple Myeloma Neoadjuvant Therapy Nerve Growth Factors Neural Conduction Neurohormones Neuropathy Neurotoxins Operative Surgical Procedures Pain Patients Peripheral Nervous System Diseases Phase Pilot Projects Placebo Control Placebos Preventive Process Questionnaires Randomized Relapse Relative (related person)Role Sample Size Schedule Serum Side Symptoms Techniques Testing Universities base cancer therapy chemotherapy cytokine design effective therapy experience improved malignant breast neoplasm minimally invasive neurotoxic neurotoxicity neurotrophic factor oncology prevent randomized placebo controlled trial response standard care treatment planning

项目摘要

DESCRIPTION (provided by applicant): One of the most harmful side effects of chemotherapy is chemotherapy-induced peripheral neuropathy (CIPN), a common, disabling and dose-limiting side effect of many chemotherapy agents for which there is no effective treatment. A small reduction in dose intensity can cause a significant decrease in relapse-free survival and overall survival. Our preliminary data showed that acupuncture significantly reduced CIPN neurotoxicity symptoms, improved nerve conduction study, and prevented chemotherapy dose reduction due to CIPN. Our central hypothesis is that acupuncture can prevent worsening of CIPN and improve tolerance of chemotherapy in breast and colorectal cancer patients receiving neurotoxin chemotherapy through increasing NGF. Our goal is to determine the effectiveness of acupuncture in reducing CIPN symptoms and preventing chemotherapy dose reduction caused by CIPN in breast and colorectal cancer patients in the neoadjuvant and adjuvant settings. We will conduct a pilot, 60- patient, randomized, placebo-controlled trial to 1) determine the effect f acupuncture on chemotherapy dose reduction, 2) determine the effect of acupuncture on prevent worsening of CIPN, and 3) identify one of the mechanisms of acupuncture in treating CIPN. Our proposed study will integrate acupuncture into oncology practice to improve to improve patients' tolerance of standard chemotherapy. Our study has the potential to identify an effective non-pharmacological treatment for CIPN and to improve cancer patients' tolerance of standard chemotherapy schedule and subsequently improve their relapse-free survival and overall survival.

描述（由申请人提供）：化学疗法最有害的副作用之一是化学疗法诱导的周围神经病（CIPN），这是许多化学疗法剂的常见，残疾和剂量限制的副作用，没有有效的治疗。剂量强度的少量降低会导致无复发生存和总体存活率显着降低。我们的初步数据表明，针灸显着降低了CIPN神经毒性症状，改善了神经传导研究，并防止了由于CIPN引起的化学疗法剂量降低。我们的中心假设是，针灸可以防止CIPN恶化，并提高乳腺癌和结直肠癌患者的化学疗法的耐受性，从而通过增加NGF接受神经毒素化疗。我们的目标是确定针灸在减少CIPN症状的有效性，并防止在新辅助和辅助环境中由CIPN和结直肠癌患者CIPN引起的化学疗法降低剂量。我们将进行一项试验，60名患者，随机，安慰剂对照试验至1）确定针灸对化学疗法剂量降低的影响，2）确定针灸对防止CIPN恶化的影响，3）确定一种确定针刺治疗CIPN的机制之一。我们提出的研究将将针灸纳入肿瘤学实践，以改善患者对标准化疗的耐受性。我们的研究有可能确定有效的非药物治疗CIPN，并提高癌症患者对标准化疗计划的耐受性，并随后提高其无复发生存和整体生存。