Mechanism of action and targeting of hexokinase II in glioblastoma

己糖激酶 II 在胶质母细胞瘤中的作用机制和靶向

• 批准号: nhmrc : 1043094
• 负责人: Prof Philip Hogg
• 金额: $ 42.92万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mechanism-action-targeting-ii-glioblastoma/111543
• 关键词: Mechanism; action; targeting; hexokinase; II

Deaths from the brain cancer, glioblastoma, are as common as from the skin cancer in Australia. For most patients diagnosed with glioblastoma there is no realistic possibility of cure or even survival beyond a few years. We propose to understand and target glioblastomas aberrant metabolism of glucose, which may lead to better treatments for this devastating cancer.

在澳大利亚，死于脑癌、胶质母细胞瘤和皮肤癌一样常见。对于大多数诊断为胶质母细胞瘤的患者来说，治愈甚至生存超过几年的可能性都是不现实的。我们建议了解和靶向胶质母细胞瘤的葡萄糖代谢异常，这可能会导致更好地治疗这种毁灭性的癌症。