Essential role of ERp5 in thrombosis

ERp5 在血栓形成中的重要作用

• 批准号: nhmrc : 1143400
• 负责人: Prof Philip Hogg
• 金额: $ 30.32万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/essential-role-erp5-thrombosis/1319950
• 关键词: Essential; role; ERp5; thrombosis

Blood clotting is the underlying cause of heart attacks and strokes. We have discovered that the protein, ERp5, is essential for normal blood clotting. Our preliminary findings indicate that ERp5 controls the function of blood platelets in clotting. Our overall aim is to elucidate how ERp5 regulates platelet function. It is crucial that we understand how ERp5 functions in blood clotting if we are to effectively target it in disease.

血液凝结是心脏病发作和中风的根本原因。我们发现，ERp5这种蛋白质对正常的血液凝结是必不可少的。我们的初步发现表明，ERp5控制着血小板的凝血功能。我们的总体目标是阐明ERp5是如何调节血小板功能的。如果我们要有效地针对疾病，了解ERp5在凝血中的作用是至关重要的。