The Ghost in the Machine: understanding how haemostasis is regulated by allosteric disulphide bonds

机器中的幽灵：了解变构二硫键如何调节止血

• 批准号: nhmrc : 1002645
• 负责人: Prof Philip Hogg
• 金额: $ 59.88万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/ghost-machine-understanding-disulphide-bonds/108839
• 关键词: Ghost; Machine; understanding; how; haemostasis

Genes encode proteins, which are the machinery of life. All life forms make proteins that contain bonds between pairs of cysteine amino acids called disulphide bonds. Prof Hogg has discovered a type of disulphide bond, the allosteric disulphide, which controls how proteins work by breaking or forming in a precise way. His research aim is to define how haemostasis is controlled by allosteric disulphides. Haemostasis gone wrong leads to heart attack and stroke.

基因编码蛋白质，蛋白质是生命的机器。所有生命形式产生的蛋白质都含有半胱氨酸对之间的键，称为二硫键。霍格教授发现了一种二硫键，即变构二硫键，它通过精确的断裂或形成来控制蛋白质的工作方式。他的研究目的是确定变构二硫化物如何控制止血。止血出错会导致心脏病和中风。